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Any process that stops, prevents or reduces the frequency, rate or extent of the glycosylation of one or more amino acid residues within a protein. Protein amino acid glycosylation is the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. Any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process by which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein. Any process that decreases the rate, frequency, or extent of protein amino acid glutathionylation. Protein amino acid glutathionylation is the protein modification process by which a glutathione molecule is added to a protein amino acid through a disulfide linkage. Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin moieties from a protein. Any process the stops, prevents or reduces the frequency, rate or extent of removal of phosphate groups from a protein. Any process that decreases the frequency, rate or extent of protein amino acid ADP-ribosylation. Protein amino acid ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids. Any process that decreases the rate frequency or extent of the covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of a histone. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell. Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein. Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein. The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of SUMO moieties to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein. The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of protein modification process
Acc: GO:0031400
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
Synonyms:
  • down-regulation of protein modification
  • downregulation of protein modification
  • inhibition of protein modification
  • down regulation of protein modification
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 237 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031400 - negative regulation of protein modification process (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle