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Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Any process that stops, prevents or reduces the frequency, rate or extent of activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal. Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Any process that modulates the activity of an enzyme. Any process by which an organism stops, prevents or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction. Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds. Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor. Any process that stops or reduces the activity of an enzyme. Any process that stops or reduces the activity of a cyclase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of catalytic activity
Acc: GO:0043086
Aspect: Biological Process
Desc: Any process that stops or reduces the activity of an enzyme.
Synonyms:
  • down-regulation of enzyme activity
  • negative regulation of enzyme activity
  • downregulation of enzyme activity
  • inhibition of enzyme activity
  • down regulation of enzyme activity
Proteins in PDR annotated with:
   This term: 66 [Search]
   Term or descendants: 616 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043086 - negative regulation of catalytic activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle