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Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Any process that decreases the rate frequency or extent of anaphase-promoting complex activity regulating the mitotic cell cycle. Any process that modulates the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that stops, prevents or reduces the frequency, rate or extent of the addition of ubiquitin moieties to a protein. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle. A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Acc: GO:0051436
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle.
Synonyms:
  • mitotic anaphase-promoting complex inhibitor
  • down regulation of ubiquitin ligase activity during mitotic cell cycle
  • mitotic APC inhibition
  • down-regulation of ubiquitin ligase activity during mitotic cell cycle
  • anaphase promoting complex inhibition during mitotic cell cycle
  • inhibition of ubiquitin ligase activity during mitotic cell cycle
  • mitotic SCF complex inhibitor
  • mitotic ubiquitin ligase inhibitor
  • mitotic anaphase-promoting complex inhibition
  • mitotic APC inhibitor
  • anaphase-promoting complex inhibition during mitotic cell cycle
  • mitotic anaphase promoting complex inhibition
  • APC inhibition during mitotic cell cycle
  • downregulation of ubiquitin ligase activity during mitotic cell cycle
  • mitotic anaphase promoting complex inhibitor
  • negative regulation of ubiquitin ligase activity during mitotic cell cycle
  • negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
Proteins in PDR annotated with:
   This term: 81 [Search]
   Term or descendants: 83 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051436 - negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle