YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CTI6
  • nucleus
  • positive regulation of transcription
  • histone deacetylation
  • histone deacetylase activity
  • transcription factor binding
  • DEP1
  • nucleus
  • telomere maintenance
  • phospholipid metabolic process
  • histone deacetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone deacetylase activity
  • transcription regulator activity
  • EAF3
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • histone deacetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • histone deacetylase activity
  • PHO23
  • nucleus
  • histone deacetylase complex
  • chromatin modification
  • histone deacetylation
  • histone deacetylase activity
  • RCO1
  • nucleus
  • histone deacetylase complex
  • histone deacetylation
  • histone deacetylase activity
  • RPD3
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • protein amino acid deacetylation
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • chromatin organization
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • mitotic recombination
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • RXT2
  • nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • conjugation with cellular fusion
  • invasive growth in response to glucose limitation
  • histone deacetylation
  • histone deacetylase activity
  • SAP30
  • histone deacetylase complex
  • chromatin silencing at rDNA
  • telomere maintenance
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • histone deacetylase activity
  • SDS3
  • nucleus
  • Rpd3L-Expanded complex
  • Rpd3L complex
  • chromatin silencing
  • histone deacetylation
  • histone deacetylase activity
  • SIN3
  • Sin3 complex
  • histone deacetylase complex
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
  • UME1
  • nucleus
  • regulation of meiosis
  • histone deacetylation
  • histone deacetylase activity
  • transcription corepressor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylase complex 5.362E-13 11 23 6 6292
    chromatin remodeling complex 5.6493E-9 11 99 6 6292
    nucleoplasm part 3.602E-8 11 245 7 6292
    nucleoplasm 6.0476E-8 11 264 7 6292
    nuclear lumen 2.453E-6 11 453 7 6292
    nucleus 4.1084E-6 11 2041 11 6292
    Sin3-type complex 2.771E-5 11 5 2 6292
    organelle lumen 3.0633E-5 11 660 7 6292
    intracellular organelle lumen 3.0633E-5 11 660 7 6292
    membrane-enclosed lumen 4.5212E-5 11 700 7 6292
    nuclear part 8.5482E-4 11 1103 7 6292
    protein complex 1.0346E-3 11 1137 7 6292
    Rpd3L complex 1.7483E-3 11 1 1 6292
    Rpd3L-Expanded complex 1.7483E-3 11 1 1 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    nuclear chromatin 6.8247E-3 11 73 2 6292
    Sin3 complex 6.9763E-3 11 4 1 6292
    chromatin 7.5696E-3 11 77 2 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292
    macromolecular complex 9.4307E-3 11 1635 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone deacetylation 8.58E-28 11 27 11 6292
    protein amino acid deacetylation 2.2768E-27 11 29 11 6292
    covalent chromatin modification 2.1062E-21 11 88 11 6292
    histone modification 2.1062E-21 11 88 11 6292
    chromatin modification 3.5505E-18 11 168 11 6292
    chromatin organization 3.0188E-17 11 203 11 6292
    post-translational protein modification 1.6939E-14 11 357 11 6292
    protein modification process 7.0473E-13 11 499 11 6292
    chromosome organization 2.2963E-12 11 555 11 6292
    macromolecule modification 3.0277E-12 11 569 11 6292
    cellular protein metabolic process 3.4344E-9 11 1074 11 6292
    organelle organization 5.8482E-9 11 1127 11 6292
    protein metabolic process 6.3855E-9 11 1136 11 6292
    regulation of transcription 2.516E-8 11 384 8 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.6431E-8 11 415 8 6292
    regulation of nitrogen compound metabolic process 4.732E-8 11 416 8 6292
    regulation of gene expression 8.0432E-8 11 445 8 6292
    regulation of macromolecule biosynthetic process 9.7449E-8 11 456 8 6292
    regulation of cellular biosynthetic process 1.2775E-7 11 472 8 6292
    regulation of biosynthetic process 1.2989E-7 11 473 8 6292
    regulation of macromolecule metabolic process 1.6591E-7 11 488 8 6292
    cellular component organization 2.4732E-7 11 1582 11 6292
    regulation of primary metabolic process 2.4909E-7 11 514 8 6292
    regulation of cellular process 3.4548E-7 11 796 9 6292
    regulation of cellular metabolic process 3.4561E-7 11 536 8 6292
    regulation of metabolic process 4.0499E-7 11 547 8 6292
    transcription 4.3477E-7 11 552 8 6292
    regulation of biological process 4.6806E-7 11 824 9 6292
    regulation of transcription, DNA-dependent 4.9323E-7 11 358 7 6292
    regulation of RNA metabolic process 5.4238E-7 11 363 7 6292
    chromatin silencing at rDNA 3.1985E-6 11 18 3 6292
    negative regulation of transcription, DNA-dependent 3.7152E-6 11 157 5 6292
    negative regulation of RNA metabolic process 3.8335E-6 11 158 5 6292
    negative regulation of transcription 4.6073E-6 11 164 5 6292
    negative regulation of gene expression 4.6073E-6 11 164 5 6292
    transcription, DNA-dependent 4.9786E-6 11 503 7 6292
    RNA biosynthetic process 5.3219E-6 11 508 7 6292
    negative regulation of macromolecule biosynthetic process 6.3422E-6 11 175 5 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.2837E-6 11 180 5 6292
    negative regulation of nitrogen compound metabolic process 7.2837E-6 11 180 5 6292
    negative regulation of biosynthetic process 9.2532E-6 11 189 5 6292
    negative regulation of cellular biosynthetic process 9.2532E-6 11 189 5 6292
    negative regulation of macromolecule metabolic process 9.9952E-6 11 192 5 6292
    biological regulation 1.3531E-5 11 1213 9 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    negative regulation of cellular metabolic process 1.5131E-5 11 209 5 6292
    negative regulation of metabolic process 1.5488E-5 11 210 5 6292
    negative regulation of gene expression, epigenetic 1.8201E-5 11 100 4 6292
    gene silencing 1.8201E-5 11 100 4 6292
    regulation of gene expression, epigenetic 1.8201E-5 11 100 4 6292
    chromatin silencing 1.8201E-5 11 100 4 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    chromatin silencing at silent mating-type cassette 2.1082E-5 11 33 3 6292
    regulation of transcription from RNA polymerase II promoter 2.3113E-5 11 228 5 6292
    negative regulation of cellular process 3.6122E-5 11 250 5 6292
    negative regulation of biological process 3.8266E-5 11 253 5 6292
    chromatin silencing at telomere 9.9258E-5 11 55 3 6292
    negative regulation of transcription from RNA polymerase II promoter 1.2885E-4 11 60 3 6292
    transcription from RNA polymerase II promoter 1.4703E-4 11 335 5 6292
    cellular macromolecule biosynthetic process 1.5044E-4 11 1187 8 6292
    macromolecule biosynthetic process 1.5233E-4 11 1189 8 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    gene expression 2.6734E-4 11 1283 8 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    RNA metabolic process 3.3963E-4 11 954 7 6292
    metabolic process 5.03E-4 11 3157 11 6292
    nucleic acid metabolic process 5.475E-4 11 1415 8 6292
    double-strand break repair via nonhomologous end joining 8.1559E-4 11 25 2 6292
    positive regulation of transcription 8.1643E-4 11 112 3 6292
    positive regulation of gene expression 8.1643E-4 11 112 3 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.5062E-4 11 118 3 6292
    positive regulation of nitrogen compound metabolic process 9.5062E-4 11 118 3 6292
    positive regulation of macromolecule biosynthetic process 9.5062E-4 11 118 3 6292
    positive regulation of biosynthetic process 1.0227E-3 11 121 3 6292
    positive regulation of cellular biosynthetic process 1.0227E-3 11 121 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.1391E-3 11 1566 8 6292
    cellular biosynthetic process 1.1444E-3 11 1567 8 6292
    positive regulation of macromolecule metabolic process 1.1504E-3 11 126 3 6292
    positive regulation of metabolic process 1.2317E-3 11 129 3 6292
    positive regulation of cellular metabolic process 1.2317E-3 11 129 3 6292
    biosynthetic process 1.3405E-3 11 1602 8 6292
    positive regulation of cellular process 1.4353E-3 11 136 3 6292
    positive regulation of biological process 1.466E-3 11 137 3 6292
    non-recombinational repair 1.5121E-3 11 34 2 6292
    DNA metabolic process 1.9612E-3 11 585 5 6292
    cellular nitrogen compound metabolic process 2.7182E-3 11 1770 8 6292
    nitrogen compound metabolic process 2.9528E-3 11 1791 8 6292
    DNA repair 3.8513E-3 11 192 3 6292
    double-strand break repair 4.2084E-3 11 57 2 6292
    response to DNA damage stimulus 6.8745E-3 11 236 3 6292
    positive regulation of transcription from RNA polymerase II promoter 8.9583E-3 11 84 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein deacetylase activity 8.4908E-27 11 32 11 6292
    histone deacetylase activity 8.4908E-27 11 32 11 6292
    deacetylase activity 2.7457E-26 11 35 11 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 1.4869E-24 11 48 11 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 6.8951E-22 11 80 11 6292
    hydrolase activity 5.5655E-10 11 911 11 6292
    transcription factor binding 6.0286E-7 11 43 4 6292
    transcription corepressor activity 2.1992E-6 11 16 3 6292
    catalytic activity 7.2915E-6 11 2150 11 6292
    transcription cofactor activity 3.7921E-5 11 40 3 6292
    transcription repressor activity 5.0638E-5 11 44 3 6292
    transcription coactivator activity 5.731E-4 11 21 2 6292
    transcription regulator activity 2.0191E-3 11 339 4 6292
    transcription activator activity 4.8071E-3 11 61 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle