Protein Overview: MKK2

General Information:
Name(s) found:	MKK2 / YPL140C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	506 amino acids
Gene Ontology:
Cellular Component:	intracellular [TAS]
Biological Process:	signal transduction [IMP] protein amino acid phosphorylation [ISS]
Molecular Function:	MAP kinase kinase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES PYSNNSTSAT  60
   61 STTSSMASNS TLLYNRSSTT TIKNRPVPPP LPPLVLTQKK DGIEYRVAGD SQLSERFSNL 120
  121 HVDITYKELL SSAPISTKLS NIDTTFIKKD LDTPEGEDSY PSTLLSAYDF SSSGSNSAPL 180
  181 SANNIISCSN LIQGKDVDQL EEEAWRFGHL KDEITTLGIL GEGAGGSVAK CRLKNGKKVF 240
  241 ALKTINTMNT DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI AMEYMGGKSL 300
  301 EATYKNLLKR GGRISERVIG KIAESVLRGL SYLHERKVIH RDIKPQNILL NEKGEIKLCD 360
  361 FGVSGEAVNS LAMTFTGTSF YMAPERIQGQ PYSVTCDVWS LGLTLLEVAG GRFPFESDKI 420
  421 TQNVAPIELL TMILTFSPQL KDEPELDISW SKTFRSFIDY CLKKDARERP SPRQMLKHPW 480
  481 IVGQMKKKVN MERFVKKCWE KEKDGI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AHA1 ARP2 ATP3 AVO1 BCK1 BUL1 CCT2 CCT3 CCT5 CDC20 CLU1 CPR6 CYS4 DHH1 DPB2 EGD2 FOL2 FUN12 GAL7 GND1 GPH1 IDH1 ILV2 ILV5 IMD4 IPP1 KIC1 KIN2 LHS1 LYS12 MAD3 MDH1 MET16 MKK2 MKT1 NOG2 NPA3 OYE2 PDC6 PDX1 PHO85 PIL1 PMA1 POL30 PRB1 PUF3 QCR2 RCN2 RGD1 RNQ1 RPN1 RPN12 RPN6 RPN7 RPT3 RVB1 SIS1 SKG3 SLT2 SLX1 SMK1 SRP54 STI1 TCP1 TEM1 TFC7 TIF1, TIF2 VMA8 YER077C YGR266W YKR051W YKU80 YLR271W YPR003C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RGD2	MKK2	1	Unpublished Fields Lab Data
View Screen	ECM29	MKK2	1	Unpublished Fields Lab Data
View Screen	YHR122W	MKK2	1	Hazbun TR, et al. (2003)
View Screen	PRP40	MKK2	1	Unpublished Fields Lab Data
View Screen	PNO1	MKK2	1	Unpublished Fields Lab Data
View Screen	MPC54	MKK2	1	Unpublished Fields Lab Data
View Screen	PDI1	MKK2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MKK2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..77]	PSI-BLAST	2.69897	pak1 autoregulatory domain
2	View Details	[78..170]	deduced	N/A	No confident structure predictions are available.
3	View Details	[171..294]	PSI-BLAST	395.0	pak1
4	View Details	[295..506]	PSI-BLAST	395.0	pak1

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2