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View Structure Prediction Details

Protein: MKK2
Organism: Saccharomyces cerevisiae
Length: 506 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MKK2.

Description E-value Query
Range
Subject
Range
gi|218443 - gi|218443|dbj|BAA02933.1| Mkk2 protein kinase [Saccharomyces cerevisiae]
0.0 [1..506] [1..506]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
0.0 [17..503] [92..541]
PAK3_RAT - Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1
0.0 [17..503] [92..541]
gi|21953248, gi|... - gi|31419805|gb|AAH53403.1| P21 (CDKN1A)-activated kinase 3 [Mus musculus], gi|21953248|emb|CAD42790....
gi|117616564 - gi|117616564|gb|ABK42300.1| Pak3 [synthetic construct]
0.0 [17..503] [92..541]
PAK3_XENLA - Serine/threonine-protein kinase PAK 3 OS=Xenopus laevis GN=pak3 PE=2 SV=1
0.0 [18..503] [108..561]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
0.0 [17..503] [92..541]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES PYSNNSTSAT  60
   61 STTSSMASNS TLLYNRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [78-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTTIKNRPV PPPLPPLVLT QKKDGIEYRV AGDSQLSERF SNLHVDITYK ELLSSAPIST  60
   61 KLSNIDTTFI KKDLDTPEGE DSYPSTLLSA YDF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [171-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGSNSAPL SANNIISCSN LIQGKDVDQL EEEAWRFGHL KDEITTLGIL GEGAGGSVAK  60
   61 CRLKNGKKVF ALKTINTMNT DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI 120
  121 AMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 395.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [295-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGKSLEATY KNLLKRGGRI SERVIGKIAE SVLRGLSYLH ERKVIHRDIK PQNILLNEKG  60
   61 EIKLCDFGVS GEAVNSLAMT FTGTSFYMAP ERIQGQPYSV TCDVWSLGLT LLEVAGGRFP 120
  121 FESDKITQNV APIELLTMIL TFSPQLKDEP ELDISWSKTF RSFIDYCLKK DARERPSPRQ 180
  181 MLKHPWIVGQ MKKKVNMERF VKKCWEKEKD GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 395.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle