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View Structure Prediction Details

Protein: MKK2
Organism: Saccharomyces cerevisiae
Length: 506 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MKK2.

Description E-value Query
Range
Subject
Range
gi|218443 - gi|218443|dbj|BAA02933.1| Mkk2 protein kinase [Saccharomyces cerevisiae]
0.0 [1..506] [1..506]
gi|189491751, gi... - gi|57284082|emb|CAI43167.1| p21 protein (Cdc42/Rac)-activated kinase 3 [Homo sapiens], gi|57284006|e...
gi|157170250 - gi|157170250|gb|AAI52762.1| P21 protein (Cdc42/Rac)-activated kinase 3 [synthetic construct]
ENSPTRT00000049237 - null
0.0 [17..503] [92..541]
PAK3_RAT - Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1
0.0 [17..503] [92..541]
gi|21953248, gi|... - gi|31419805|gb|AAH53403.1| P21 (CDKN1A)-activated kinase 3 [Mus musculus], gi|21953248|emb|CAD42790....
gi|117616564 - gi|117616564|gb|ABK42300.1| Pak3 [synthetic construct]
0.0 [17..503] [92..541]
PAK3_XENLA - Serine/threonine-protein kinase PAK 3 OS=Xenopus laevis GN=pak3 PE=2 SV=1
0.0 [18..503] [108..561]
gi|1168176 - gi|1168176|gb|AAB35358.1| mPAK-3=p21Cdc42/Rac activated kinase [mice, fibroblast, Peptide, 543 aa]
0.0 [17..503] [92..541]

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Predicted Domain #1
Region A:
Residues: [1-77]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASMFRPPES NRSHQKTPKL TLPVNLVQNA KSTNDGQHLN RSPYSSVNES PYSNNSTSAT  60
   61 STTSSMASNS TLLYNRS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.69897
Match: 1f3mA_
Description: pak1 autoregulatory domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [78-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTTIKNRPV PPPLPPLVLT QKKDGIEYRV AGDSQLSERF SNLHVDITYK ELLSSAPIST  60
   61 KLSNIDTTFI KKDLDTPEGE DSYPSTLLSA YDF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.406 b.36.1 PDZ domain-like
View Download 0.376 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.313 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.406 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.293 a.61.1 Retroviral matrix proteins
View Download 0.276 a.24.17 Group V grass pollen allergen
View Download 0.272 a.158.1 F-box domain
View Download 0.269 d.198.1 Type III secretory system chaperone
View Download 0.267 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.241 a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.231 a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.225 d.38.1 Thioesterase/thiol ester dehydrase-isomerase
View Download 0.206 a.39.1 EF-hand

Predicted Domain #3
Region A:
Residues: [171-294]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSGSNSAPL SANNIISCSN LIQGKDVDQL EEEAWRFGHL KDEITTLGIL GEGAGGSVAK  60
   61 CRLKNGKKVF ALKTINTMNT DPEYQKQIFR ELQFNKSFKS DYIVQYYGMF TDEQSSSIYI 120
  121 AMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 395.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [295-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGKSLEATY KNLLKRGGRI SERVIGKIAE SVLRGLSYLH ERKVIHRDIK PQNILLNEKG  60
   61 EIKLCDFGVS GEAVNSLAMT FTGTSFYMAP ERIQGQPYSV TCDVWSLGLT LLEVAGGRFP 120
  121 FESDKITQNV APIELLTMIL TFSPQLKDEP ELDISWSKTF RSFIDYCLKK DARERPSPRQ 180
  181 MLKHPWIVGQ MKKKVNMERF VKKCWEKEKD GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 395.0
Match: 1f3mC_
Description: pak1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle