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Protein Overview: GAS1

General Information:
Name(s) found: GAS1 / YMR307W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 559 amino acids

    Gene Ontology:
    Cellular Component: fungal-type cell wall [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: filamentous growth [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    Molecular Function: 1,3-beta-glucanosyltransferase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFKSLSKLA TAAAFFAGVA TADDVPAIEV VGNKFFYSNN GSQFYIRGVA YQADTANETS  60
   61 GSTVNDPLAN YESCSRDIPY LKKLNTNVIR VYAINTTLDH SECMKALNDA DIYVIADLAA 120
  121 PATSINRDDP TWTVDLFNSY KTVVDTFANY TNVLGFFAGN EVTNNYTNTD ASAFVKAAIR 180
  181 DVRQYISDKN YRKIPVGYSS NDDEDTRVKM TDYFACGDDD VKADFYGINM YEWCGKSDFK 240
  241 TSGYADRTAE FKNLSIPVFF SEYGCNEVTP RLFTEVEALY GSNMTDVWSG GIVYMYFEET 300
  301 NKYGLVSIDG NDVKTLDDFN NYSSEINKIS PTSANTKSYS ATTSDVACPA TGKYWSAATE 360
  361 LPPTPNGGLC SCMNAANSCV VSDDVDSDDY ETLFNWICNE VDCSGISANG TAGKYGAYSF 420
  421 CTPKEQLSFV MNLYYEKSGG SKSDCSFSGS ATLQTATTQA SCSSALKEIG SMGTNSASGS 480
  481 VDLGSGTESS TASSNASGSS SKSNSGSSGS SSSSSSSSAS SSSSSKKNAA TNVKANLAQV 540
  541 VFTSIISLSI AAGVGFALV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ABP1 ACO1 ADH6 AIM41 ATP4 BUD14 CAR2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 GAS1 GCN3 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 ILV5 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RNR2 RPC19 RPM2 SAH1 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIR1 SIR3 SIT4 TEF4 TMA19 TMA29 TSR1 VMA4 YBR225W YER138C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GAS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..342] Pfam 236.327902 Glycolipid anchored surface protein (GAS1) No confident structure predictions are available.
    2 View Details [343..559] MSA 44.092985 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glucan 1,3-beta-glucosidase activity
    		•  4.74305379082042 bayes_pls_golite062009
  • beta-glucosidase activity
    		•  4.08728799854386 bayes_pls_golite062009
  • glucosidase activity
    		•  3.42748790579187 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.01041615773553 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  1.61656834219722 bayes_pls_golite062009
  • chitinase activity
    		•  1.4346953725386 bayes_pls_golite062009
  • catalytic activity
    		•  1.16922094690912 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  1.07809807579681 bayes_pls_golite062009
  • receptor activity
    		•  0.997368806469636 bayes_pls_golite062009
  • hydrolase activity
    		•  0.897719018829634 bayes_pls_golite062009
  • binding
    		•  0.730318626805434 bayes_pls_golite062009
  • pattern binding
    		•  0.288637430529209 bayes_pls_golite062009
  • protein binding
    		•  0.163871180877406 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.133746936940599 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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