Protein Overview: ZDS2

General Information:
Name(s) found:	ZDS2 / YML109W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|798891\|emb\|CAA89109.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323527\|ref\|NP_013598.1\| Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p; Zds2p [Saccharomyces cerevisiae] [NCBI NR] gi\|1731425\|sp\|P54786.1\|ZDS2_YEAST RecName: Full=Protein ZDS2 [NCBI NR] pir\|\|S53963 MCS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Protein ZDS2 OS=Saccharomyces cerevisiae GN=ZDS2 PE=1 SV=1 [Swiss-Prot] ZDS2 Multicopy suppressor of sin4 [mips] Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p [SGD] ZDS2, Chr XIII from 51640-54468 [yeast_orfs2] Chr XIII from 51640-54468 [yeastorf3.fasta] (P54786) ZDS2 protein [4932.FASTACCERV.txt] ZDS2 SGDID:S0004577, Chr XIII from 51640-54468, Verified ORF [yeastflysequest.fasta] Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p [Saccharomyces cerevisiae]gi\|798891\|emb\|CAA89109.1\| unknown [Saccharomyces cerevisiae]gi\|1731425\|sp\|P54786\|ZDS2_YEAST ZDS2 proteingi [nrdb_11152004_Chlamydomonas] ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Verified ORF, "Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Verified ORF, "Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paral [yeast-200209-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; paralog of Zds1p; Zds2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein ZDS2 [nr-271106-contam.fasta] ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Verified ORF, "Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Protein ZDS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZDS2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Genome Release 64-1-1, Verified ORF, "Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p" [yeast-030211-contam.fasta] ZDS2 SGDID:S000004577, Chr XIII from 51640-54468, Genome Release 64-2-1, Verified ORF, "Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YML109W SGDID:S000004577, Chr XIII from 51640-54468, Genome Release 64-1-1, Verified ORF, "Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	942 amino acids
Gene Ontology:
Cellular Component:	nucleus [IPI]
Biological Process:	chromatin silencing at rDNA [IMP] cell aging [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLMEDMQNK DGHNTVENSS GGTDSNNNIQ MRRMRKTQLS KKELFEKRKS DVLIAAKSLD  60
   61 TEIQNVKNLK RLSIGSMDLV IDPELEFKVN SRNSYSSDSS KESLQESLHE ENIIRSEQKE 120
  121 EQGSEDNDAY EEGDATNVDD SIDITQTEYL HDEETLEKEK IIRNASSSTS SSARVTSRNR 180
  181 RLSGVKTLAH DVVLDVENDH DSKMVDLTQN LLWVPADQHP NVKPENYLEL IQDTLQNIQI 240
  241 STNQDIDENK LELGNNHVIS NRKRTGSVVR RPSRLKTSYT KFDDEPPLAD KPQEGEIQVD 300
  301 KRISSSDIKT IRSVSLKEIT EELTKISNNA GLTDSDAVTL ARSLSMSGSF TNESLHLNGN 360
  361 HTENDNEFAS NMFNETGLTI PERSSLRRSK FNTYKIRLEG SSLPQAVKLN SLMNIQTNDN 420
  421 RRSASSPASY TQVPQEQASL NDFHEIFDHY RRTSTDWSTE NEKYVDSTNY YSDEEDLTHA 480
  481 SISQESSLLS TDSSNNSVLI KPHNTGSMIS EKLDQHVSSS EKSNTNNSEA NHGWSWLNSS 540
  541 NGSLNANEQT YQQLTDDEDD EECVDNEKAD FVNLSVSRRA KSTKRASERI NHSKNRHSPI 600
  601 FQIHSEEAKS VVITPSVVSS SESQPSKPTA PAVVEKKVEL PTDTQASTHK KNSLEKRLAK 660
  661 LFKRKQHNGT CKSDVKVIKK SVKKELKKKA SHSSLSKFRK SPKKKPQEAE VERPSSPTKT 720
  721 ITTEDIDTAS VIEPEVRSSN ASTLLPDSHT SHSSEFVVET ISELDGDDSF DISGGDVNYD 780
  781 VEVHSSISRD TTAGLEEDIG AEREDNTSPT APQISTLPPR KLTFEDVVKP DYSNAPIKFT 840
  841 DSAFGFPLPM ITNSTVIMFD HRLGINVERA IYRLSHLKLS DPGRELRQQV LLSNFMYSYL 900
  901 NLVNHTLYME QVGTGDIAFN GDSALGMMDK NDSDGTILIP DI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC55 PPH21 PPH22 TPD3 ZDS1 ZDS2
View Details	Krogan NJ, et al. (2006)		CDC55 FIR1 PHR1 PPH21 PPH22 RRD2 TPD3 YRR1 ZDS1 ZDS2
View Details	Gavin AC, et al. (2006)		CDC55 RTS3 TPD3 ZDS1 ZDS2
View Details	Gavin AC, et al. (2002)		BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
View Details	Ho Y, et al. (2002)		AVT2 HOS4 SIF2 SNT1 TFP1 TRM3 UTP21 YMR155W YRF1-3, YRF1-7 ZDS2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ZDS2	CLA4	2	Drees BL, et al. (2001)
View Screen	GIC2	ZDS2	2	Drees BL, et al. (2001)
View Screen	GIC1	ZDS2	2	Drees BL, et al. (2001)
View Screen	ZDS1	ZDS2	2	Drees BL, et al. (2001)
View Screen	SKG6	ZDS2	2	Drees BL, et al. (2001)
View Screen	IMP4	ZDS2	2	Unpublished Fields Lab Data
View Screen	RHO1	ZDS2	2	Drees BL, et al. (2001)
View Screen	ZDS2	YAL004W	2	Drees BL, et al. (2001)
View Screen	ZDS2	CDC11	2	Drees BL, et al. (2001)
View Screen	ZDS2	RRP14	2	Drees BL, et al. (2001)
View Screen	ZDS2	CSM1	2	Unpublished Fields Lab Data
View Screen	ZDS2	YEL023C	2	Drees BL, et al. (2001)
View Screen	ZDS2	SPR6	2	Drees BL, et al. (2001)
View Screen	ZDS2	ZDS2	2	Drees BL, et al. (2001)
View Screen	BOI1	ZDS2	2	Drees BL, et al. (2001)
View Screen	ZDS2	BNI1	2	Drees BL, et al. (2001)
View Screen	SWI5	ZDS2	1	Unpublished Fields Lab Data
View Screen	ZDS2	CTT1	1	Unpublished Fields Lab Data
View Screen	ZDS2	MSM1	1	Unpublished Fields Lab Data
View Screen	ZDS2	YOL163W	1	Unpublished Fields Lab Data
View Screen	ZDS2	YGR266W	1	Unpublished Fields Lab Data
View Screen	ZDS2	SPO11	1	Unpublished Fields Lab Data
View Screen	UBI4	ZDS2	1	Unpublished Fields Lab Data
View Screen	ZDS2	BIG1	1	Unpublished Fields Lab Data
View Screen	ZDS2	LTE1	1	Unpublished Fields Lab Data
View Screen	ZDS2	YJR120W	1	Unpublished Fields Lab Data
View Screen	ZDS2	YBL029W	1	Unpublished Fields Lab Data
View Screen	ZDS2	RAM2	1	Unpublished Fields Lab Data
View Screen	ZDS2	YBL096C	1	Unpublished Fields Lab Data
View Screen	ZDS2	YKR011C	1	Unpublished Fields Lab Data
View Screen	ZDS2	CBS1	1	Unpublished Fields Lab Data
View Screen	ZDS2	GIS3	1	Unpublished Fields Lab Data
View Screen	ZDS2	FOB1	1	Unpublished Fields Lab Data
View Screen	ZDS2	ACS2	1	Unpublished Fields Lab Data
View Screen	ZDS2	SCC2	1	Unpublished Fields Lab Data
View Screen	ZDS2	YLR290C	1	Unpublished Fields Lab Data
View Screen	ZDS2	REC102	1	Unpublished Fields Lab Data
View Screen	ZDS2	DSE1	1	Drees BL, et al. (2001)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ZDS2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..131]	deduced	N/A	No confident structure predictions are available.
2	View Details	[132..516]	ab initio	11.32	No description for 1jv2B was found.
3	View Details	[517..600]	ab initio	11.32	No description for 1jv2B was found.
4	View Details	[601..819]	ab initio	13.87	No description for 1m2vB was found.
5	View Details	[820..942]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2