Protein Overview: SFP1

General Information:
Name(s) found:	SFP1 / YLR403W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	683 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][TAS] cytoplasm [IDA]
Biological Process:	transcription from RNA polymerase III promoter [IGI][IPI][TAS] regulation of cell size [IGI][IMP] ribosome biogenesis [IMP]
Molecular Function:	transcription factor activity [IGI][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFTTMTMAS NMATSTTTTA TSAHASINSS SNFNIDIDSN QNTPSILINN NSDSSNGKNT  60
   61 DFNGVNNIHQ KNIMNNTNNV HLYSPNIMDQ TLLTPQDIAK LRRESIAHSQ GMGGVSWGSI 120
  121 SVGSWLRDEI ISRRNSIVPA SANGAASAAA SATTTATNTL QIQQPTKRPS VSNPPYHRGY 180
  181 SISPQIAYTA YLPNLEKQYC KDYSCCGLSL PGLHDLLRHY EEAHISTSPN TTNMSQIPMN 240
  241 SAGNTSSSVR MTNNTSSANY NLQNNMAANT KNAGHKTNTM QAHSSNATNN TSINNMHANL 300
  301 QSNMDSNSTI RQSQHPHHQQ NIIQQQLQSN SVNHTSGAVP TPSVMGSATA SSTTANPNVI 360
  361 SITGAPNSGL SMANHSQQLH LNGNLVDAVS TNDVFLRTSN SPSRHVPHNK QINSNNNSGI 420
  421 NINNNTSHNS NINMGSKNAM VNRPHTFNNY SLNKTSRNPI QHQSRKIDPH QTDLSPLVLV 480
  481 QDIDLSFMDD DILGPSNHNS MNSVVNPTTG SHNYNTFHSS VHAKSSQNMV EDQDIDDIDD 540
  541 DDDVDDDDDD DDDDDTENGS SSNGKSVHNN NYKMPQQAYI DDPARRLYVM DHEEQKPFKC 600
  601 PVIGCEKTYK NQNGLKYHRL HGHQNQKLHE NPDGTFSVID PDSTDSFGDG MGSAKDKPYR 660
  661 CEVCGKRYKN LNGLKYHRGH STH

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ASF1 HIR1 HIR2 HIR3 HPC2 QDR2 SFP1
View Details	Ho Y, et al. (2002)		CDC37 CIC1 CKA1 CKA2 CKB1 CKB2 CTK1 DBP10 ENP2 GBP2 GDE1 HHF1, HHF2 HOT1 HPR1 HRB1 KRE33 KRI1 LAS1 MRPL1 MRS6 NOC3 NOP12 NOP2 NOP7 NPL3 PDI1 POB3 POL2 PSK2 PUF6 PWP1 RNQ1 RPN1 RRP14 RRP5 SET1 SFP1 SGS1 SIT4 SPT16 SSF1 SUV3 SWD3 TIF4631 TRL1 UTP22 VMR1 VPS73 WTM2 YRA1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SFP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..113]	deduced	N/A	Confident ab initio structure predictions are available.
2	View Details	[114..323]	MSA	9.840997	View MSA. No confident structure predictions are available.
3	View Details	[324..434]	PSI-BLAST	28.69897	Designed zinc finger protein
4	View Details	[435..511]	MSA	6.062994	View MSA. No confident structure predictions are available.
5	View Details	[512..589]	PSI-BLAST	48.39794	Five-finger GLI1
6	View Details	[590..683]	PSI-BLAST	48.39794	Five-finger GLI1

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
transcription regulator activity	4.47951889934838	bayes_pls_golite062009
DNA binding	4.06558617622942	bayes_pls_golite062009
nucleic acid binding	3.94726902110129	bayes_pls_golite062009
transcription factor activity	3.0829185849524	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.05542379535543	bayes_pls_golite062009
transcription activator activity	1.97757778483124	bayes_pls_golite062009
transcription repressor activity	1.44763794968807	bayes_pls_golite062009
transcription factor binding	1.23738346570539	bayes_pls_golite062009
sequence-specific DNA binding	1.18927065676691	bayes_pls_golite062009
chromatin binding	1.14387291281112	bayes_pls_golite062009
protein binding	0.952480850696098	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.668979099236657	bayes_pls_golite062009
transcription cofactor activity	0.627794176881836	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

5

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
DNA binding	4.31726585409267	bayes_pls_golite062009
nucleic acid binding	4.18253042271426	bayes_pls_golite062009
transcription factor activity	3.30488091451207	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.31369346002275	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
transcription repressor activity	1.64349785387632	bayes_pls_golite062009
chromatin binding	1.41340072049908	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
sequence-specific DNA binding	1.35040510840599	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.94201971474109	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

6

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle