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View Structure Prediction Details

Protein: SFP1
Organism: Saccharomyces cerevisiae
Length: 683 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SFP1.

Description E-value Query
Range
Subject
Range
ZNF347 - zinc finger protein 347
gi|208968133 - gi|208968133|dbj|BAG73905.1| zinc finger protein 347 [synthetic construct]
0.0 [55..682] [200..813]
ZN252_CANLF - Zinc finger protein 252 OS=Canis lupus familiaris GN=ZNF252 PE=2 SV=1
0.0 [44..681] [248..870]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFTTMTMAS NMATSTTTTA TSAHASINSS SNFNIDIDSN QNTPSILINN NSDSSNGKNT  60
   61 DFNGVNNIHQ KNIMNNTNNV HLYSPNIMDQ TLLTPQDIAK LRRESIAHSQ GMG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.942 0.011 nucleus d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)

Predicted Domain #2
Region A:
Residues: [114-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVSWGSISVG SWLRDEIISR RNSIVPASAN GAASAAASAT TTATNTLQIQ QPTKRPSVSN  60
   61 PPYHRGYSIS PQIAYTAYLP NLEKQYCKDY SCCGLSLPGL HDLLRHYEEA HISTSPNTTN 120
  121 MSQIPMNSAG NTSSSVRMTN NTSSANYNLQ NNMAANTKNA GHKTNTMQAH SSNATNNTSI 180
  181 NNMHANLQSN MDSNSTIRQS QHPHHQQNII 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
DNA binding 4.06558617622942 bayes_pls_golite062009
nucleic acid binding 3.94726902110129 bayes_pls_golite062009
transcription factor activity 3.0829185849524 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.05542379535543 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
transcription repressor activity 1.44763794968807 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
sequence-specific DNA binding 1.18927065676691 bayes_pls_golite062009
chromatin binding 1.14387291281112 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.668979099236657 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [324-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQQLQSNSVN HTSGAVPTPS VMGSATASST TANPNVISIT GAPNSGLSMA NHSQQLHLNG  60
   61 NLVDAVSTND VFLRTSNSPS RHVPHNKQIN SNNNSGININ NNTSHNSNIN M

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 1meyG_
Description: Designed zinc finger protein
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [435-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSKNAMVNRP HTFNNYSLNK TSRNPIQHQS RKIDPHQTDL SPLVLVQDID LSFMDDDILG  60
   61 PSNHNSMNSV VNPTTGS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [512-589]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HNYNTFHSSV HAKSSQNMVE DQDIDDIDDD DDVDDDDDDD DDDDTENGSS SNGKSVHNNN  60
   61 YKMPQQAYID DPARRLYV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.39794
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
DNA binding 4.31726585409267 bayes_pls_golite062009
nucleic acid binding 4.18253042271426 bayes_pls_golite062009
transcription factor activity 3.30488091451207 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
chromatin binding 1.41340072049908 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
sequence-specific DNA binding 1.35040510840599 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.94201971474109 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [590-683]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHEEQKPFK CPVIGCEKTY KNQNGLKYHR LHGHQNQKLH ENPDGTFSVI DPDSTDSFGD  60
   61 GMGSAKDKPY RCEVCGKRYK NLNGLKYHRG HSTH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.39794
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle