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Protein Overview: COX6

General Information:
Name(s) found: COX6 / YHR051W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 148 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial respiratory chain complex IV [IPILink to PubMed article]
    Biological Process: mitochondrial electron transport, cytochrome c to oxygen [IDALink to PubMed article]
    Molecular Function: cytochrome-c oxidase activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRAIFRNP VINRTLLRAR PGAYHATRLT KNTFIQSRKY SDAHDEETFE EFTARYEKEF  60
   61 DEAYDLFEVQ RVLNNCFSYD LVPAPAVIEK ALRAARRVND LPTAIRVFEA LKYKVENEDQ 120
  121 YKAYLDELKD VRQELGVPLK EELFPSSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX6 COX7 COX8 COX9
    View Details Gavin AC, et al. (2002) COX4 COX5A COX6
    View Details Ho Y, et al. (2002) BRX1 CKB1 COX6 FET4 GAR1 NIP7 NMD3 NOC2 NOP1 NOP2 NOP56 NOP7 NSA1 NSA2 NUG1 PHO84 RRP1 YPL009C
    View Details Qiu et al. (2008) ATP1 ATP14 ATP15 ATP16 ATP17 ATP18 ATP2 ATP20 ATP4 ATP5 ATP6 ATP7 ATP8 COB COR1 COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYC7 CYT1 INH1 MCR1 OLI1 QCR2 QCR6 QCR7 QCR8 QCR9 RIP1 SDH1 SDH2 SDH3 SDH4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SSH4 COX6 2 Unpublished Fields Lab Data
    View Screen UBC7 COX6 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data COX6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 178.69897 Cytochrome c oxidase subunit E

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytochrome-c oxidase activity
    		•  13.5907467824992 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors
    		•  13.5907467824992 bayes_pls_golite062009
  • oxidoreductase activity, acting on heme group of donors, oxygen as acceptor
    		•  13.5907467824992 bayes_pls_golite062009
  • heme-copper terminal oxidase activity
    		•  13.2768834037467 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  7.11269745957917 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  6.95782581983891 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  6.3444074949287 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.0779545597528 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.07124287051458 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.87041225771312 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.44223516926039 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  5.2274118132466 bayes_pls_golite062009
  • electron carrier activity
    		•  1.73787331766336 bayes_pls_golite062009
  • catalytic activity
    		•  1.17990683373825 bayes_pls_golite062009
  • transporter activity
    		•  0.0449232084165001 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.0241192035901199 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle