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Protein Overview: NIC96

General Information:
Name(s) found: NIC96 / YFR002W [SGD]
Description(s) found:
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  • gi|836757|dbj|BAA09241.1| 96KD nucleoporin-interacting component [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S35319 nucleoporin-interacting protein NIC96 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|14318524|ref|NP_116657.1| Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p; Nic96p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1171704|sp|P34077.2|NIC96_YEAST RecName: Full=Nucleoporin NIC96; AltName: Full=Nuclear pore protein NIC96; AltName: Full=96 kDa nucleoporin-interacting component [NCBI NR]
  • Nucleoporin NIC96 OS=Saccharomyces cerevisiae GN=NIC96 PE=1 SV=2 [Swiss-Prot]
  • (P34077) Nucleoporin NIC96 (Nuclear pore protein NIC96) (96 kDa nucleoporin-interacting component) [Swiss-Prot]
  • NIC96 Nuclear pore protein [mips]
  • Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p [SGD]
  • NIC96, Chr VI from 150010-152529 [yeast_orfs2]
  • Chr VI from 150010-152529 [yeastorf3.fasta]
  • Chr VI from 150011-152530 [yeastorf5.fasta]
  • (P34077) 96 kDa nucleoporin-interacting component [4932.FASTACCERV.txt]
  • NIC96 SGDID:S0001898, Chr VI from 150011-152530, Verified ORF [yeastflysequest.fasta]
  • Nic96p [Saccharomyces cerevisiae]gi|486772|pir||S35319 nucleoporin-interacting protein NIC96 - yeast (Saccharomyces cerevisiae)gi|836757|dbj|BAA09241.1| 96KD nucleoporin-interacting component [Saccharomyces cerevisiae]gi|1171704|sp|P34077|NI96_YEAST Nu [nrdb_11152004_Chlamydomonas]
  • NIC96 SGDID:S000001898, Chr VI from 150011-152530, Verified ORF, "Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Nucleoporin NIC96 (Nuclear pore protein NIC96) (96 kDa nucleoporin-interacting component) [nr-271106-contam.fasta]
  • Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p; Nic96p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • 96KD nucleoporin-interacting component [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Nucleoporin NIC96 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NIC96 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NIC96 SGDID:S000001898, Chr VI from 150016-152535, Genome Release 64-1-1, Verified ORF, "Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p" [yeast-030211-contam.fasta]
  • NIC96 SGDID:S000001898, Chr VI from 150016-152535, Genome Release 64-2-1, Verified ORF, "Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)" [20141208_orf_trans.fasta]
  • YFR002W SGDID:S000001898, Chr VI from 150016-152535, Genome Release 64-1-1, Verified ORF, "Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 839 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [IDALink to PubMed article]
    Biological Process: mRNA export from nucleus [TASLink to PubMed article]
    rRNA export from nucleus [TASLink to PubMed article]
    nuclear pore organization [IMPLink to PubMed article]
    snRNP protein import into nucleus [TASLink to PubMed article]
    mRNA-binding (hnRNP) protein import into nucleus [TASLink to PubMed article]
    snRNA export from nucleus [TASLink to PubMed article]
    protein import into nucleus [IMPLink to PubMed article]
    tRNA export from nucleus [TASLink to PubMed article]
    NLS-bearing substrate import into nucleus [TASLink to PubMed article]
    protein export from nucleus [TASLink to PubMed article]
    ribosomal protein import into nucleus [TASLink to PubMed article]
    Molecular Function: structural molecule activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLETLRGNKL HSGTSKGANK KLNELLESSD NLPSASSELG SIQVSINELR RRVFQLRSKN  60
   61 KASKDYTKAH YLLANSGLSF EDVDAFIKDL QTNQFLEPNP PKIIESEELE FYIRTKKEEN 120
  121 ILMSIEQLLN GATKDFDNFI NHNLNLDWAQ HKNEVMKNFG ILIQDKKTVD HKKSISSLDP 180
  181 KLPSWGNKGN NILNSNESRL NVNENNILRE KFENYARIVF QFNNSRQANG NFDIANEFIS 240
  241 ILSSANGTRN AQLLESWKIL ESMKSKDINI VEVGKQYLEQ QFLQYTDNLY KKNMNEGLAT 300
  301 NVNKIKSFID TKLKKADKSW KISNLTVING VPIWALIFYL LRAGLIKEAL QVLVENKANI 360
  361 KKVEQSFLTY FKAYASSKDH GLPVEYSTKL HTEYNQHIKS SLDGDPYRLA VYKLIGRCDL 420
  421 SRKNIPAVTL SIEDWLWMHL MLIKEKDAEN DPVYERYSLE DFQNIIISYG PSRFSNYYLQ 480
  481 TLLLSGLYGL AIDYTYTFSE MDAVHLAIGL ASLKLFKIDS STRLTKKPKR DIRFANILAN 540
  541 YTKSFRYSDP RVAVEYLVLI TLNEGPTDVE LCHEALRELV LETKEFTVLL GKIGRDGARI 600
  601 PGVIEERQPL LHVRDEKEFL HTITEQAARR ADEDGRIYDS ILLYQLAEEY DIVITLVNSL 660
  661 LSDTLSASDL DQPLVGPDDN SETNPVLLAR RMASIYFDNA GISRQIHVKN KEICMLLLNI 720
  721 SSIRELYFNK QWQETLSQME LLDLLPFSDE LSARKKAQDF SNLDDNIVKN IPNLLIITLS 780
  781 CISNMIHILN ESKYQSSTKG QQIDSLKNVA RQCMIYAGMI QYRMPRETYS TLINIDVSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NIC96 NSP1 NUP57
    View Details (MIPS) Mewes HW, et al. (2004) NIC96 NSP1 NUP49 NUP57
    View Details Krogan NJ, et al. (2006) NIC96 NUP49 NUP57
    View Details Gavin AC, et al. (2002) MRPL1 MRPL15 MRPL24 MRPL3 MRPL35 MRPL8 NIC96 NSP1 NUP116 NUP159 NUP82 YML6
    View Details Qiu et al. (2008) GLE2 MEX67 NDC1 NIC96 NSP1 NUP1 NUP100 NUP116 NUP120 NUP133 NUP145 NUP157 NUP159 NUP170 NUP188 NUP2 NUP42 NUP49 NUP57 NUP82 NUP84 SEC13 SUS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SDO1 NIC96 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSN5 and NIC96 Huh WK, et al. (2003)
    View Data PCT1 and NIC96 Huh WK, et al. (2003)
    View Data OPI1 and NIC96 Huh WK, et al. (2003)
    View Data SIR3 and NIC96 Huh WK, et al. (2003)
    View Data MLP1 and NIC96 Huh WK, et al. (2003)
    View Data HMG2 and NIC96 Huh WK, et al. (2003)
    View Data TRM1 and NIC96 Huh WK, et al. (2003)
    View Data THP1 and NIC96 Huh WK, et al. (2003)
    View Data PGA1 and NIC96 Huh WK, et al. (2003)
    View Data HMG1 and NIC96 Huh WK, et al. (2003)
    View Data ASI1 and NIC96 Huh WK, et al. (2003)
    View Data PML39 and NIC96 Huh WK, et al. (2003)
    View Data SIR4 and NIC96 Huh WK, et al. (2003)
    View Data NSG1 and NIC96 Huh WK, et al. (2003)
    View Data GTT3 and NIC96 Huh WK, et al. (2003)
    View Data ULP1 and NIC96 Huh WK, et al. (2003)
    View Data NIC96 Huh WK, et al. (2003)
    View Data HEH2 and NIC96 Huh WK, et al. (2003)
    View Data SRC1 and NIC96 Huh WK, et al. (2003)
    View Data ESC1 and NIC96 Huh WK, et al. (2003)
    View Data UBX6 and NIC96 Huh WK, et al. (2003)
    View Data ASI3 and NIC96 Huh WK, et al. (2003)
    View Data YPR174C and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154]
    [677..696]    		 ORFEUS 7.17 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    2 View Details [155..362]
    [482..676]
    [697..729]    		 ORFEUS 7.17 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    3 View Details [363..481] ORFEUS 7.17 5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    4 View Details [730..839] ORFEUS 9.46 Histidine ammonia-lyase (HAL)


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle