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Protein Overview: HEH2

General Information:
Name(s) found: HEH2 / YDR458C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 663 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHRNLDPKT LKVSQLRRVL VENDVAFPAN ARKPVLVKLF EEKVRQRLQS SPEASKVRTS  60
   61 IQKVVKSGAK NADRKKTLKS KKLESSSSES KTVKDENVET NKRKREQIST DNEAKMQIQE 120
  121 EKSPKKKRKK RSSKANKPPE SPPQSKSDGK ATSADLTSEL ETVEELHKKD SSDDKPRVKE 180
  181 LPKPELPNLK VSNEFLAQLN KELASAATEN YDHSIKSTDL SSIRIETEEP VGPSTGAETR 240
  241 NESEVMENIN LEVQPEVKEA KEELTKISET FDNQDEEDTS RLSSKKNIRS PKGRTRHFIA 300
  301 NKTKRGIDIM KPFIAHLFIW LWNGAIFLSI ICPILFGLWY REQRIQVGYC GHEKPLKSLA 360
  361 ISAFPQTERV DSVLQAYRPN CLECPEHGIC SSFMNVECEP GYEPKSSILE TYGIIPFPKY 420
  421 CAKDESKEKE VDELVWKVNE YLKKKNAQHE CGEGENLFES GETETKLYDI FSHSRPSWES 480
  481 QREFNDHWKN VLEILKKKDD IIWLPLDFET NGKREKSKSN NTNYIYRSTS KKWVTLQCHL 540
  541 EGDIQEYITK YGGSLFITLG VLFLIKKIQS TLDNYVQGEQ IIEKLVKEAI DKLKDVKKNK 600
  601 GEEPFLTTVQ LRATLLSDIP NIKEQNNLWA QTKEKIMKEQ SENIELYLLE ENGEIMTCWE 660
  661 WKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HEH2 Huh WK, et al. (2003)
    View Data HEH2 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254] PSI-BLAST 18.0 Heavy meromyosin subfragment
    2 View Details [255..521] deduced N/A No confident structure predictions are available.
    3 View Details [522..663] MSA 1.006963 View MSA. Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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