Protein Overview: HEH2

General Information:
Name(s) found:	HEH2 / YDR458C [SGD]
Description(s) found: Found 28 descriptions. SHOW ALL	Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle [SGD]
Organism:	Saccharomyces cerevisiae
Length:	663 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHRNLDPKT LKVSQLRRVL VENDVAFPAN ARKPVLVKLF EEKVRQRLQS SPEASKVRTS  60
   61 IQKVVKSGAK NADRKKTLKS KKLESSSSES KTVKDENVET NKRKREQIST DNEAKMQIQE 120
  121 EKSPKKKRKK RSSKANKPPE SPPQSKSDGK ATSADLTSEL ETVEELHKKD SSDDKPRVKE 180
  181 LPKPELPNLK VSNEFLAQLN KELASAATEN YDHSIKSTDL SSIRIETEEP VGPSTGAETR 240
  241 NESEVMENIN LEVQPEVKEA KEELTKISET FDNQDEEDTS RLSSKKNIRS PKGRTRHFIA 300
  301 NKTKRGIDIM KPFIAHLFIW LWNGAIFLSI ICPILFGLWY REQRIQVGYC GHEKPLKSLA 360
  361 ISAFPQTERV DSVLQAYRPN CLECPEHGIC SSFMNVECEP GYEPKSSILE TYGIIPFPKY 420
  421 CAKDESKEKE VDELVWKVNE YLKKKNAQHE CGEGENLFES GETETKLYDI FSHSRPSWES 480
  481 QREFNDHWKN VLEILKKKDD IIWLPLDFET NGKREKSKSN NTNYIYRSTS KKWVTLQCHL 540
  541 EGDIQEYITK YGGSLFITLG VLFLIKKIQS TLDNYVQGEQ IIEKLVKEAI DKLKDVKKNK 600
  601 GEEPFLTTVQ LRATLLSDIP NIKEQNNLWA QTKEKIMKEQ SENIELYLLE ENGEIMTCWE 660
  661 WKE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#13 Mitotic Prep2-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CUS1	HEH2	1	Unpublished Fields Lab Data
View Screen	GPI14	HEH2	1	Hazbun TR, et al. (2003)
View Screen	LSM8	HEH2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	HEH2	Huh WK, et al. (2003)
View Data	HEH2 and NIC96	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..254]	PSI-BLAST	18.0	Heavy meromyosin subfragment
2	View Details	[255..521]	deduced	N/A	No confident structure predictions are available.
3	View Details	[522..663]	MSA	1.006963	View MSA. Confident ab initio structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2