YRC Public Data Repository - Protein Structure Prediction

Protein:	HEH2
Organism:	Saccharomyces cerevisiae
Length:	663 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEH2.

Description	E-value	Query Range	Subject Range
HEH2 - Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localizati... HEH2_YEAST - Inner nuclear membrane protein HEH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEH2...	0.0	[1..663]	[1..663]
SPAC18G6.10 - chromosome segregation protein LEM2_SCHPO - Lap-Emerin-Man domain protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=lem2 PE=1 ...	0.0	[5..661]	[8..665]
gi\|6473492 - gi\|6473492\|dbj\|BAA87142.1\| Hypothetical protein [Schizosaccharomyces pombe]	2.0E-51	[484..661]	[1..198]
gi\|8163674 - gi\|8163674\|gb\|AAF73795.1\|AF154026_1 surface protein PspC [Streptococcus pneumoniae]	1.0E-46	[4..313]	[139..442]
gi\|25509405, gi\|... - gi\|8163644\|gb\|AAF73779.1\| surface protein PspC [Streptococcus pneumoniae], pir\|\|H98120 choline bindi... gi\|15459699, gi\|... - gi\|15904036\|ref\|NP_359586.1\| choline binding protein A [Streptococcus pneumoniae R6], gi\|15459699\|gb... gi\|116515359, gi... - gi\|8163644\|gb\|AAF73779.1\|AF154012_1 surface protein PspC [Streptococcus pneumoniae], gi\|116515359\|re...	2.0E-44	[4..316]	[139..451]

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Predicted Domain #1

Region A:
Residues: [1-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDHRNLDPKT LKVSQLRRVL VENDVAFPAN ARKPVLVKLF EEKVRQRLQS SPEASKVRTS  60
   61 IQKVVKSGAK NADRKKTLKS KKLESSSSES KTVKDENVET NKRKREQIST DNEAKMQIQE 120
  121 EKSPKKKRKK RSSKANKPPE SPPQSKSDGK ATSADLTSEL ETVEELHKKD SSDDKPRVKE 180
  181 LPKPELPNLK VSNEFLAQLN KELASAATEN YDHSIKSTDL SSIRIETEEP VGPSTGAETR 240
  241 NESEVMENIN LEVQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.0
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [255-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEVKEAKEEL TKISETFDNQ DEEDTSRLSS KKNIRSPKGR TRHFIANKTK RGIDIMKPFI  60
   61 AHLFIWLWNG AIFLSIICPI LFGLWYREQR IQVGYCGHEK PLKSLAISAF PQTERVDSVL 120
  121 QAYRPNCLEC PEHGICSSFM NVECEPGYEP KSSILETYGI IPFPKYCAKD ESKEKEVDEL 180
  181 VWKVNEYLKK KNAQHECGEG ENLFESGETE TKLYDIFSHS RPSWESQREF NDHWKNVLEI 240
  241 LKKKDDIIWL PLDFETNGKR EKSKSNN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [522-663]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNYIYRSTSK KWVTLQCHLE GDIQEYITKY GGSLFITLGV LFLIKKIQST LDNYVQGEQI  60
   61 IEKLVKEAID KLKDVKKNKG EEPFLTTVQL RATLLSDIPN IKEQNNLWAQ TKEKIMKEQS 120
  121 ENIELYLLEE NGEIMTCWEW KE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.809	N/A	N/A	f.1.4	Bcl-2 inhibitors of programmed cell death

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits