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Protein Overview: THP1

General Information:
Name(s) found: THP1 / YOL072W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Nuclear pore-associated protein, forms a complex with Sac3p that is involved in transcription and in mRNA export from the nucleus; contains a PAM domain implicated in protein-protein binding [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    nuclear pore [IDALink to PubMed article][IGILink to PubMed article]
    Biological Process: RNA export from nucleus [IMPLink to PubMed article]
    cellular bud site selection [IMPLink to PubMed article]
    DNA recombination [IMPLink to PubMed article]
    RNA elongation from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDMANQLLDE LAHGNFSHLT LNLSQNGREI AILQKQLTGF DDKQLETFVE QHPAMPNDTR  60
   61 FKIMCTSFLN YARDVDPWSA WSSSDLIFEF YQCLINCLIN DNAPHIEMLI PVATRETEFI 120
  121 INLAGKLDSF HLQLHTRSHQ FLSHISSILS RLFNSIKPPR GNASSTNIPG KQRILLYLVN 180
  181 KLNNIYFRIE SPQLCSNIFK NFQPKSMLAH FNEYQLDQQI EYRYLLGRYY LLNSQVHNAF 240
  241 VQFNEAFQSL LNLPLTNQAI TRNGTRILNY MIPTGLILGK MVKWGPLRPF LSQETIDNWS 300
  301 VLYKHVRYGN IQGVSLWLRQ NERHLCARQL LIVLLEKLPM VTYRNLIKTV IKSWTTEWGQ 360
  361 NKLPYSLIER VLQLSIGPTF EDPGAQEITI YNGIHSPKNV ENVLVTLINL GLLRANCFPQ 420
  421 LQLCVVKKTT MIQEIVPPVN ERITKMFPAH SHVLW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARL3 CDC123 ECM31 PHO13 TEF1, TEF2 THP1 YIH1
    View Details Qiu et al. (2008) SUS1 THP1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data THP1 and NIC96 Huh WK, et al. (2003)
    View Data THP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..107] ab initio 7.27 No description for 1hz4A was found.
    2 View Details [108..224] ab initio 7.27 No description for 1hz4A was found.
    3 View Details [225..380] ab initio 7.27 No description for 1hz4A was found.
    4 View Details [381..455] MSA 1.024986 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle