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Protein Overview: YIH1

General Information:
Name(s) found: YIH1 / YCR059C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 258 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: regulation of cellular amino acid metabolic process [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDHEQLVE ELEAVEAIYP DLLSKKQEDG SIIVVKVPQH EYMTLQISFP THYPSEEAPN  60
   61 VIEVGVCTSL AKRDLYDTKY LQHLFQEVMD SVFHRGSVCL FDFLTELDGV LYVEPEEETE 120
  121 PVQQSDIPTD PFEGWTASDP ITDRGSTFMA FAAHVTSEEQ AFAMLDLLKT DSKMRKANHV 180
  181 MSAWRIKQDG SAATYQDSDD DGETAAGSRM LHLITIMDVW NVIVVVARWF GGAHIGPDRF 240
  241 KHINSTAREA VVRAGFDS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARL3 CDC123 ECM31 PHO13 TEF1, TEF2 THP1 YIH1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YIH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] MSA 2.008997 View MSA. No confident structure predictions are available.
    2 View Details [109..258] Pfam 62.853872 Uncharacterized protein family UPF0029 No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transferase activity, transferring phosphorus-containing groups
    		•  2.55433995647388 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.26982378355508 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  2.17994566452938 bayes_pls_golite062009
  • kinase activity
    		•  2.16946639423557 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.0116317330767 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90728659801871 bayes_pls_golite062009
  • structural molecule activity
    		•  1.77722756041008 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.75408506104351 bayes_pls_golite062009
  • DNA binding
    		•  1.50208874269692 bayes_pls_golite062009
  • binding
    		•  1.50032731466041 bayes_pls_golite062009
  • transferase activity
    		•  1.25037643378444 bayes_pls_golite062009
  • catalytic activity
    		•  0.878454819018611 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.825588323751637 bayes_pls_golite062009
  • nuclease activity
    		•  0.234623495149702 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.21915720954962 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.20391251413344 bayes_pls_golite062009
  • protein binding
    		•  0.191135371876197 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle