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Protein Overview: ASI1

General Information:
Name(s) found: ASI1 / YMR119W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IGILink to PubMed article][ISSLink to PubMed article]
    nuclear inner membrane [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSTSSENV FINSFSYLNQ TSQAVISGNS TFANVINFPY RLGLSFIGAV NLQYEQTVKS  60
   61 EEIPPTLRSV FDTIGFFFSP YAIFCFVIAI VLNRFVVFYA VLNNGSRRTL PLWLSNVFHV 120
  121 SAVVVLAMVS LGPLTLGKDF KILGDPAFAQ EKFLLNIFYA FAYSYCVETI FTIMRNSSPL 180
  181 EGTDYSLFEL SIQFYTMTNN NTKFLDSPDY IIDCSMAILS RILIHLVEIF RLRNYRLLFS 240
  241 TIMNLCHICY LGIRVKQGGW KSLPFSVKFR HFPKLFSVSI ICLSLLIFKL SCLIRWDPFG 300
  301 KSRNSCELLQ FYPLSRNWKK YLNYTGEEDF SAMATKFALL LCSGTELMEK GIRREFPAIN 360
  361 IPDNVNEKFF ISGYLNELSK PYKENTSISF PKKNSSILKQ RFFLMFPKSI IWIMKKLVGQ 420
  421 VFFGFRDNKD EDIPDNDPSK MLKITKTNSL NNSAGHKEDI ELELLNTSDD EYSEDYEPSE 480
  481 VESLGDSDEE NLEEDSLIFN ETRDALLDLF SSEDNEVHTD YNWIMSTSRI LQQKLLSDKT 540
  541 LTRASILDTK LSEVDETFGT ESDFDLSCAV CKVNERNTVL WPCRCFAICE DCRISLGLRG 600
  601 FSTCVCCRSK VHGYCKVHPV SDSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ASI1 ASI2 ASI3 HRD1 SSM4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ASI1 and NIC96 Huh WK, et al. (2003)
    View Data ASI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..296] deduced N/A No confident structure predictions are available.
    2 View Details [297..565] PSI-BLAST 16.09691 Heavy meromyosin subfragment
    3 View Details [566..624] PSI-BLAST 13.045757 Cbl; N-terminal domain of cbl (N-cbl); CBL
    4 View Details [560..624] PSI-BLAST 14.522879 Cbl; N-terminal domain of cbl (N-cbl); CBL


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle