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Protein Overview: ASI3

General Information:
Name(s) found: ASI3 / YNL008C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IGILink to PubMed article][ISSLink to PubMed article]
    nuclear inner membrane [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSNCSITRD VFSFFHNKTG NLNYLDNTTQ KPEVFVSPNS TIVSAPTLDS FQALMEKGNF  60
   61 TTLQLAKVGI RMFFSYSVSK YAVLCFSTAI ILNRLTVMSS LRSNSTNIRL PLWSKTLLHL 120
  121 VATLSLVKAL LQILSQFGLM HELHVSDTDF YALSVYLFVA LSDCIEIFIS STTNVPSLIC 180
  181 SDFSIWGLSL NLYIISKMPA GQQHIGDNVE LLGAVFHRLV IHLVELFHIR AYRLCGEVIL 240
  241 NAGFFTAFVT RTYLNGLDFI NICLIHNYFP GFFYISTILL ASIGIFLKAL FTSNPFRSLY 300
  301 SRYKNLEKWW RSNNYNGEEE FNEIALSLCL LLTSNDYKIF KKSDNVKSVD EVAAFSNSYV 360
  361 VSGHLNQLQS TPEDLLSRKE MTTDSQLPGF ARTYLGLFEL VRTIILTYSR LLKNLLWSKN 420
  421 FESSIDKKPR VGKRKKRDLN KYVTEKNYKK FLYKPDVKEL NIESDLRSLE LLLPEDDSSK 480
  481 DYFPPRKIDE SVSDEEFDSD MESQLIIDEE KELTHLSSNA VDSDDLEEIA WNISMWSILN 540
  541 YEMDVHNKVN GPLTRSQYGK RNPQGVLVDV VIERLLHHTN SRYMYKRLNM KDDDKLEFKF 600
  601 DFAFDSCDEV EEMDLSCLIC KVNKRNIVTW PCRCLALCDD CRISLGYKGF ATCVSCDSEV 660
  661 KGYSKLNIV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ASI3 POR1 YNL260C
    View Details Qiu et al. (2008) ASI1 ASI3 SSM4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ASI3 Huh WK, et al. (2003)
    View Data ASI3 and NIC96 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..417] MSA 1.005835 View MSA. No confident structure predictions are available.
    2 View Details [418..484] deduced N/A No confident structure predictions are available.
    3 View Details [485..616] ab initio 7.73 No description for 1fbvA was found.
    4 View Details [617..669] ab initio 7.73 No description for 1fbvA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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