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Protein Overview: PMI40

General Information:
Name(s) found: PMI40 / YER003C [SGD]
Description(s) found:
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  • gi|729984|sp|P29952.4|MPI_YEAST RecName: Full=Mannose-6-phosphate isomerase; AltName: Full=Phosphomannose isomerase; Short=PMI; AltName: Full=Phosphohexomutase [NCBI NR]
  • gi|6320839|ref|NP_010918.1| Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation; Pmi40p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|603595|gb|AAB64536.1| Pmi40p: mannose-6-phosphate isomerase [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50461 mannose-6-phosphate isomerase (EC 5.3.1.8) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Mannose-6-phosphate isomerase OS=Saccharomyces cerevisiae GN=PMI40 PE=1 SV=4 [Swiss-Prot]
  • Mannose-6-phosphate isomerase - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • PMI40 Mannose-6-phosphate isomerase [mips]
  • Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation [SGD]
  • PMI40, Chr V from 157735-157765,157859-159117, reverse complement [yeast_orfs2]
  • Chr V from 157735-157765,157859-159117, reverse complement [yeastorf3.fasta]
  • Chr V from 159117-159087,158993-157735, reverse complement [yeastorf5.fasta]
  • PMI40 SGDID:S0000805, Chr V from 159117-159087,158993-157735, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Pmi40p [Saccharomyces cerevisiae]gi|729984|sp|P29952|MANA_YEAST Mannose-6-phosphate isomerase (Phosphomannose isomerase) (PMI) (Phosphohexomutase)gi|603595|gb|AAB64536.1| Pmi40p: mannose-6-phosphate isomerase [Saccharomyces cerevisiae]gi|1078096|pir||S [nrdb_11152004_Chlamydomonas]
  • PMI40 SGDID:S000000805, Chr V from 159117-159087,158993-157735, reverse complement, Verified ORF, "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Mannose-6-phosphate isomerase (Phosphomannose isomerase) (PMI) (Phosphohexomutase) [nr-271106-contam.fasta]
  • Pmi40p: mannose-6-phosphate isomerase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation; Pmi40p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Mannose-6-phosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMI40 PE=1 SV=4 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PMI40 SGDID:S000000805, Chr V from 158994-157736,159118-159088, Genome Release 64-1-1, reverse complement, Verified ORF, "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" [yeast-030211-contam.fasta]
  • PMI40 SGDID:S000000805, Chr V from 158994-157736,159118-159088, Genome Release 64-2-1, reverse complement, Verified ORF, "Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" [20141208_orf_trans.fasta]
  • YER003C SGDID:S000000805, Chr V from 158994-157736,159118-159088, Genome Release 64-1-1, reverse complement, Verified ORF, "Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: cell wall mannoprotein biosynthetic process [IMPLink to PubMed article]
    GDP-mannose biosynthetic process [IMPLink to PubMed article]
    protein amino acid glycosylation [IMPLink to PubMed article]
    Molecular Function: mannose-6-phosphate isomerase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKLFRLDA GYQQYDWGKI GSSSAVAQFA AHSDPSVQIE QDKPYAELWM GTHSKMPSYN  60
   61 HESKESLRDI ISKNPSAMLG KDIIDKFHAT NELPFLFKVL SIEKVLSIQA HPDKALGKIL 120
  121 HAQDPKNYPD DNHKPEMAIA VTDFEGFCGF KPLQEIADEL KRIPELRNIV GEETSRNFIE 180
  181 NIQPSAQKGS PEDEQNKKLL QAVFSRVMNA SDDKIKIQAR SLVERSKNSP SDFNKPDLPE 240
  241 LIQRLNKQFP DDVGLFCGCL LLNHCRLNAG EAIFLRAKDP HAYISGDIME CMAASDNVVR 300
  301 AGFTPKFKDV KNLVSMLTYT YDPVEKQKMQ PLKFDRSSGN GKSVLYNPPI EEFAVLETTF 360
  361 DEKLGQRHFE GVDGPSILIT TKGNGYIKAD GQKLKAEPGF VFFIAPHLPV DLEAEDEAFT 420
  421 TYRAFVEPN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARG3 ATP3 BUD30 CIK1 GAL80 PMI40 SGN1 YGR250C YML002W YOR1
    View Details Ho Y, et al. (2002) ACS2 ADE3 ADE6 ADO1 ALA1 APE2 ARA1 ARG1 BAT1 CDC10 CDC33 CLU1 COR1 CYS3 DED81 DPS1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KGD2 KRS1 LPD1 LSP1 MDH3 OLA1 PAB1 PFK2 PGM2 PMI40 PRP6 RVB2 RVS161 RVS167 SAC6 SCP160 SES1 SOD1 SSZ1 THR4 TRP5 TRR1 UBA1 YDL124W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PMI40 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..429] PSI-BLAST 1682.0 Phosphomannose isomerase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  1.86690435826277 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.64913898350018 bayes_pls_golite062009
  • DNA binding
    		•  1.57178406956273 bayes_pls_golite062009
  • binding
    		•  1.54596514444405 bayes_pls_golite062009
  • transcription factor activity
    		•  0.937392765385803 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.8581504516071 bayes_pls_golite062009
  • catalytic activity
    		•  0.401988496917198 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    		•  0.353173877157675 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting aldoses and ketoses
    		•  0.348782780143283 bayes_pls_golite062009
  • protein binding
    		•  0.110960530780648 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle