Protein Overview: PTC1

General Information:
Name(s) found:	PTC1 / YDL006W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|683691\|emb\|CAA88353.1\| protein serine/threonine phosphatase PTC1 (L14593) [Saccharomyces cerevisiae] [NCBI NR] gi\|6320198\|ref\|NP_010278.1\| Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separ [NCBI NR] pir\|\|S41854 phosphoprotein phosphatase (EC 3.1.3.16) PTC1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|464326\|sp\|P35182.1\|PP2C1_YEAST RecName: Full=Protein phosphatase 2C homolog 1; Short=PP2C-1 [NCBI NR] gi\|402503\|gb\|AAA34920.1\| phosphoprotein phosphatase [Saccharomyces cerevisiae] [NCBI NR] gi\|1430965\|emb\|CAA98562.1\| PTC1 [Saccharomyces cerevisiae] [NCBI NR] Protein phosphatase 2C homolog 1 OS=Saccharomyces cerevisiae GN=PTC1 PE=1 SV=1 [Swiss-Prot] (P35182) Protein phosphatase 2C homolog 1 (EC 3.1.3.16) (PP2C-1) [Swiss-Prot] PTC1 Protein serine/threonine phosphatase 2c [mips] Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation [SGD] PTC1, Chr IV from 439905-440750 [yeast_orfs2] Chr IV from 439905-440750 [yeastorf3.fasta] PTC1 SGDID:S0002164, Chr IV from 439906-440751, Verified ORF [yeastflysequest.fasta] Ptc1p [Saccharomyces cerevisiae]gi\|1430965\|emb\|CAA98562.1\| PTC1 [Saccharomyces cerevisiae]gi\|683691\|emb\|CAA88353.1\| protein serine/threonine phosphatase PTC1 (L14593) [Saccharomyces cerevisiae]gi\|464326\|sp\|P35182\|P2C1_YEAST Protein phosphatase 2C homol [nrdb_11152004_Chlamydomonas] PTC1 SGDID:S000002164, Chr IV from 439906-440751, Verified ORF, "Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] PTC1 SGDID:S000002164, Chr IV from 439907-440752, Verified ORF, "Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] PTC1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] phosphoprotein phosphatase [nr-271106-contam.fasta] protein serine/threonine phosphatase PTC1 (L14593) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein phosphatase 2C homolog 1 (PP2C-1) [nr-271106-contam.fasta] Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation; Ptc1p [Saccharomyces [nr-271106-contam.fasta] PTC1 SGDID:S000002164, Chr IV from 439907-440752, Verified ORF, "Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation" [yeast-bovrabprots.fasta] PTC1 SGDID:S000002164, Chr IV from 439906-440751, Verified ORF, "Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation" [yeast-contam_custom.fasta] [chemostatdb.fasta] Protein phosphatase 2C homolog 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PTC1 SGDID:S000002164, Chr IV from 439909-440754, Genome Release 64-1-1, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation" [yeast-030211-contam.fasta] PTC1 SGDID:S000002164, Chr IV from 439909-440754, Genome Release 64-2-1, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation" [20141208_orf_trans.fasta] TR6485\|c0_g1_i1\|g.4578 ORF TR6485\|c0_g1_i1\|g.4578 TR6485\|c0_g1_i1\|m.4578 type:complete len:282 (+) TR6485\|c0_g1_i1:386-1231(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR5334\|c0_g1_i1\|g.3605 ORF TR5334\|c0_g1_i1\|g.3605 TR5334\|c0_g1_i1\|m.3605 type:complete len:282 (+) TR5334\|c0_g1_i1:386-1231(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YDL006W SGDID:S000002164, Chr IV from 439909-440754, Genome Release 64-1-1, Verified ORF, "Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_410\|g.566 ORF asmbl_410\|g.566 asmbl_410\|m.566 type:complete len:282 (+) asmbl_410:385-1230(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_779\|g.841 ORF asmbl_779\|g.841 asmbl_779\|m.841 type:complete len:282 (+) asmbl_779:388-1233(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_410\|g.544 ORF ID=asmbl_410\|g.544 ID=asmbl_410\|m.544 type:complete len:282 (+) ID=asmbl_410:385-1230(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_783\|g.225 ORF ID=asmbl_783\|g.225 ID=asmbl_783\|m.225 type:complete len:282 (+) ID=asmbl_783:388-1233(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	281 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	mitochondrion inheritance [IMP] inactivation of MAPK activity involved in osmosensory signaling pathway [IDA][IGI][IMP] protein amino acid dephosphorylation [IDA ] telomere maintenance [IMP] tRNA splicing, via endonucleolytic cleavage and ligation [IMP]
Molecular Function:	protein serine/threonine phosphatase activity [IDA][IEA] phosphoprotein phosphatase activity [IEA] metal ion binding [IEA] catalytic activity [IEA] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNHSEILER PETPYDITYR VGVAENKNSK FRRTMEDVHT YVKNFASRLD WGYFAVFDGH  60
   61 AGIQASKWCG KHLHTIIEQN ILADETRDVR DVLNDSFLAI DEEINTKLVG NSGCTAAVCV 120
  121 LRWELPDSVS DDSMDLAQHQ RKLYTANVGD SRIVLFRNGN SIRLTYDHKA SDTLEMQRVE 180
  181 QAGGLIMKSR VNGMLAVTRS LGDKFFDSLV VGSPFTTSVE ITSEDKFLIL ACDGLWDVID 240
  241 DQDACELIKD ITEPNEAAKV LVRYALENGT TDNVTVMVVF L

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		NBP2 PBS2 PTC1
View Details	Gavin AC, et al. (2002)		ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
View Details	Ho Y, et al. (2002)		ARE2 BIO3 CDC53 HMG2 NBP2 PBS2 PDA1 PEP3 PTC1 SEC7 SKM1 TPD3 TSL1 YLR352W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MET30	PTC1	1	Unpublished Fields Lab Data
View Screen	LIA1	PTC1	1	Unpublished Fields Lab Data
View Screen	YLR224W	PTC1	1	Unpublished Fields Lab Data
View Screen	YKU80	PTC1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..281]	PSI-BLAST	397.512579	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.46633224572308	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.25564034681743	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.66354576593165	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.62997267604309	bayes_pls_golite062009
hydrolase activity	2.5631136269171	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	0.425331902048676	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2