YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes:	This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Kss1. The topolgies of protein complexes in this experiment are unknown.
Complex Size:	26 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ARP7	nucleus SWI/SNF complex RSC complex	ATP-dependent chromatin remodeling	DNA-dependent ATPase activity general RNA polymerase II transcription factor activity
DIG1	nucleus	telomere maintenance invasive growth in response to glucose limitation	DNA binding transcription factor binding
DIG2	nucleus	invasive growth in response to glucose limitation	transcription factor binding
FET4	integral to plasma membrane plasma membrane	low-affinity iron ion transport intracellular copper ion transport copper ion import	iron ion transmembrane transporter activity copper ion transmembrane transporter activity
GFA1	cellular_component	cell wall chitin biosynthetic process	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GUS1	cytoplasm methionyl glutamyl tRNA synthetase complex	glutamyl-tRNA aminoacylation	glutamate-tRNA ligase activity
HAS1	nuclear envelope nucleolus	ribosome biogenesis rRNA processing	RNA binding RNA-dependent ATPase activity ATP-dependent RNA helicase activity
HXT6	mitochondrion plasma membrane	hexose transport	fructose transmembrane transporter activity glucose transmembrane transporter activity mannose transmembrane transporter activity
KSS1	nucleus	invasive growth in response to glucose limitation signal transduction during filamentous growth	MAP kinase activity
MKT1	polysome cytoplasm	interspecies interaction between organisms positive regulation of translation	nuclease activity
MSE1	mitochondrion	glutamyl-tRNA aminoacylation translation	glutamate-tRNA ligase activity
NAP1	nucleus cytoplasm nuclear nucleosome	M phase of mitotic cell cycle budding cell bud growth nucleosome assembly	histone binding
PHO84	integral to plasma membrane	phosphate transport manganese ion transport	inorganic phosphate transmembrane transporter activity manganese ion transmembrane transporter activity
PIM1	mitochondrial matrix mitochondrion	response to heat proteolysis	ATP-dependent peptidase activity
PMA1	mitochondrion membrane raft plasma membrane	proton transport regulation of pH	hydrogen-exporting ATPase activity, phosphorylative mechanism
PYC1	cytosol	gluconeogenesis NADPH regeneration	pyruvate carboxylase activity
RGC1	cytoplasm	biological_process	molecular_function
RPA135	DNA-directed RNA polymerase I complex	transcription from RNA polymerase I promoter ribosome biogenesis	DNA-directed RNA polymerase activity
RPN10	proteasome regulatory particle, base subcomplex proteasome complex	ubiquitin-dependent protein catabolic process	endopeptidase activity
SEN1	nucleus nuclear outer membrane	snRNA processing tRNA processing snoRNA processing transcription termination termination of RNA polymerase II transcription	DNA-dependent ATPase activity RNA helicase activity RNA-dependent ATPase activity RNA polymerase II transcription termination factor activity 5'-3' DNA helicase activity
STE12	nucleus	positive regulation of transcription from RNA polymerase II promoter by pheromones conjugation with cellular fusion pseudohyphal growth invasive growth in response to glucose limitation	transcription factor activity
STE7	cytoplasm mating projection tip	pseudohyphal growth invasive growth in response to glucose limitation protein amino acid phosphorylation pheromone-dependent signal transduction involved in conjugation with cellular fusion	MAP kinase kinase activity
TEC1	nucleus	pseudohyphal growth invasive growth in response to glucose limitation positive regulation of transcription from RNA polymerase II promoter	specific RNA polymerase II transcription factor activity
UBI4	cytoplasm	protein deubiquitination ascospore formation protein polyubiquitination protein monoubiquitination response to stress protein ubiquitination	protein tag ATP-dependent protein binding
YDR239C	cytoplasm ribosome	biological_process	molecular_function
YHR033W	cytoplasm	biological_process	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
integral to plasma membrane	6.2251E-3	26	29	2	6292
intrinsic to plasma membrane	8.0141E-3	26	33	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
invasive growth in response to glucose limitation	2.5704E-8	26	47	6	6292
filamentous growth of a population of unicellular organisms	1.3245E-6	26	90	6	6292
growth of unicellular organism as a thread of attached cells	1.3245E-6	26	90	6	6292
growth	1.3612E-6	26	145	7	6292
filamentous growth	3.4728E-6	26	106	6	6292
glutamyl-tRNA aminoacylation	4.9138E-5	26	3	2	6292
pseudohyphal growth	2.6276E-3	26	68	3	6292
low-affinity iron ion transport	4.1322E-3	26	1	1	6292
cell growth	4.6238E-3	26	83	3	6292
cation transport	6.7409E-3	26	95	3	6292
tRNA aminoacylation for protein translation	8.0141E-3	26	33	2	6292
tRNA aminoacylation	8.0141E-3	26	33	2	6292
amino acid activation	8.0141E-3	26	33	2	6292
interspecies interaction between organisms	8.248E-3	26	2	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
glutamate-tRNA ligase activity	4.9138E-5	26	3	2	6292
ATPase activity, coupled	3.0644E-4	26	149	5	6292
ATPase activity	1.4956E-3	26	211	5	6292
glutamine-fructose-6-phosphate transaminase (isomerizing) activity	4.1322E-3	26	1	1	6292
ATP-dependent protein binding	4.1322E-3	26	1	1	6292
RNA polymerase II transcription termination factor activity	4.1322E-3	26	1	1	6292
transition metal ion transmembrane transporter activity	5.8105E-3	26	28	2	6292
RNA-dependent ATPase activity	6.2251E-3	26	29	2	6292
inorganic cation transmembrane transporter activity	7.9841E-3	26	101	3	6292
transcription termination factor activity	8.248E-3	26	2	1	6292
pyruvate carboxylase activity	8.248E-3	26	2	1	6292
hydrogen-exporting ATPase activity, phosphorylative mechanism	8.248E-3	26	2	1	6292
ATP-dependent peptidase activity	8.248E-3	26	2	1	6292
di-, tri-valent inorganic cation transmembrane transporter activity	8.9854E-3	26	35	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis