YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	16 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
AEP3	cytoplasm mitochondrion extrinsic to membrane mitochondrial inner membrane	mRNA metabolic process	molecular_function
CDC20	anaphase-promoting complex	mitotic spindle elongation activation of mitotic anaphase-promoting complex activity cyclin catabolic process mitotic sister chromatid segregation mitotic metaphase/anaphase transition	enzyme activator activity
FAB1	mitochondrion late endosome vacuolar membrane vacuole	vacuole organization late endosome to vacuole transport phospholipid metabolic process negative regulation of transcription from RNA polymerase II promoter by glucose Golgi to vacuole transport	1-phosphatidylinositol-3-phosphate 5-kinase activity phosphatidylinositol-3-phosphate binding
FOL2	nucleus cytoplasm	folic acid and derivative biosynthetic process	GTP cyclohydrolase I activity
GZF3	nucleus	negative regulation of transcription from RNA polymerase II promoter nitrogen compound metabolic process negative regulation of transcription regulation of nitrogen utilization	transcription factor activity specific RNA polymerase II transcription factor activity
LSP1	cytoplasm mitochondrion mitochondrial outer membrane eisosome	response to heat endocytosis	protein kinase inhibitor activity
NOP13	nucleolus nucleoplasm	ribosome biogenesis	RNA binding
PIL1	cytoplasm mitochondrion mitochondrial outer membrane eisosome	response to heat protein localization endocytosis	protein kinase inhibitor activity
PKH1	cytosol	MAPKKK cascade involved in cell wall biogenesis protein amino acid phosphorylation endocytosis	protein kinase activity
PRP16	spliceosomal complex	RNA splicing generation of catalytic spliceosome for second transesterification step mRNA processing	ATP-dependent RNA helicase activity
PSK2	cytoplasm mitochondrion	hexose metabolic process protein amino acid phosphorylation	protein serine/threonine kinase activity
RGC1	cytoplasm	biological_process	molecular_function
RPL9B	ribonucleoprotein complex cytoplasm cytosolic large ribosomal subunit ribosome intracellular	translation	structural constituent of ribosome
YLR179C	nucleus cytoplasm	biological_process	molecular_function
YMR086W	cytoplasm ribosome	biological_process	molecular_function
YTA6	cell cortex	biological_process	ATPase activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
eisosome	6.0632E-6	16	2	2	6292
cell cortex	2.403E-3	16	109	3	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
endocytosis	1.2978E-3	16	88	3	6292
membrane invagination	1.5705E-3	16	94	3	6292
response to heat	1.6197E-3	16	24	2	6292
response to temperature stimulus	2.7007E-3	16	31	2	6292
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	5.0798E-3	16	2	1	6292
positive regulation of nuclear division	5.0798E-3	16	2	1	6292
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.0798E-3	16	2	1	6292
positive regulation of mitotic metaphase/anaphase transition	5.0798E-3	16	2	1	6292
positive regulation of mitosis	5.0798E-3	16	2	1	6292
positive regulation of proteolysis	5.0798E-3	16	2	1	6292
activation of mitotic anaphase-promoting complex activity	5.0798E-3	16	2	1	6292
activation of anaphase-promoting complex activity	5.0798E-3	16	2	1	6292
regulation of proteasomal ubiquitin-dependent protein catabolic process	7.6106E-3	16	3	1	6292
positive regulation of organelle organization	7.6106E-3	16	3	1	6292
positive regulation of protein ubiquitination	7.6106E-3	16	3	1	6292
positive regulation of protein catabolic process	7.6106E-3	16	3	1	6292
positive regulation of cellular component organization	7.6106E-3	16	3	1	6292
positive regulation of ubiquitin-protein ligase activity	7.6106E-3	16	3	1	6292
positive regulation of ligase activity	7.6106E-3	16	3	1	6292
positive regulation of protein modification process	7.6106E-3	16	3	1	6292
vesicle-mediated transport	9.0817E-3	16	340	4	6292
negative regulation of transcription from RNA polymerase II promoter	9.8479E-3	16	60	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
protein kinase inhibitor activity	3.2905E-4	16	11	2	6292
kinase inhibitor activity	3.2905E-4	16	11	2	6292
enzyme inhibitor activity	2.0507E-3	16	27	2	6292
GTP cyclohydrolase activity	2.5429E-3	16	1	1	6292
GTP cyclohydrolase I activity	2.5429E-3	16	1	1	6292
1-phosphatidylinositol-3-phosphate 5-kinase activity	2.5429E-3	16	1	1	6292
phosphatidylinositol phosphate kinase activity	5.0798E-3	16	2	1	6292
protein kinase regulator activity	5.8791E-3	16	46	2	6292
kinase regulator activity	6.6504E-3	16	49	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis