YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes:	MIPS hand-curated complex set. MIPS complex ID: 510.190.110
Complex Size:	13 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
CAF16	cytoplasm CCR4-NOT complex	regulation of transcription, DNA-dependent	ATPase activity
CAF4	mitochondrion CCR4-NOT complex	regulation of transcription, DNA-dependent mitochondrial fission	protein binding
CCR4	cytoplasm Cdc73/Paf1 complex CCR4-NOT core complex	response to drug traversing start control point of mitotic cell cycle nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
CDC36	nucleus cytoplasm CCR4-NOT core complex	negative regulation of transcription from RNA polymerase II promoter response to pheromone involved in conjugation with cellular fusion nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
CDC39	nucleus cytoplasm CCR4-NOT core complex	negative regulation of transcription from RNA polymerase II promoter response to pheromone involved in conjugation with cellular fusion pseudohyphal growth nuclear-transcribed mRNA poly(A) tail shortening nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity
DBF2	cellular bud neck spindle pole body	nuclear division protein amino acid phosphorylation	protein serine/threonine kinase activity
DHH1	cytoplasm cytoplasmic mRNA processing body	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA	protein binding RNA helicase activity
IBA57	mitochondrion	biological_process	molecular_function
MOB1	cellular bud neck spindle pole body	regulation of exit from mitosis protein amino acid phosphorylation	kinase regulator activity
MOT2	cytoplasm CCR4-NOT core complex	conjugation with cellular fusion telomere maintenance nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity transcription repressor activity
NOT3	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
NOT5	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter protein ubiquitination	ubiquitin-protein ligase activity 3'-5'-exoribonuclease activity
POP2	cytoplasm CCR4-NOT core complex	nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	3'-5'-exoribonuclease activity

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
CCR4-NOT complex	3.3704E-23	13	14	9	6292
CCR4-NOT core complex	1.7767E-19	13	8	7	6292
transcription factor complex	1.2133E-15	13	71	9	6292
nucleoplasm part	1.1115E-10	13	245	9	6292
nucleoplasm	2.1759E-10	13	264	9	6292
nuclear lumen	2.6533E-8	13	453	9	6292
organelle lumen	7.0793E-7	13	660	9	6292
intracellular organelle lumen	7.0793E-7	13	660	9	6292
membrane-enclosed lumen	1.1759E-6	13	700	9	6292
nuclear part	5.5135E-5	13	1103	9	6292
protein complex	7.088E-5	13	1137	9	6292
macromolecular complex	1.7639E-4	13	1635	10	6292
organelle part	4.9114E-4	13	2282	11	6292
intracellular organelle part	4.9114E-4	13	2282	11	6292
cytoplasm	5.8578E-4	13	3552	13	6292
microtubule organizing center	7.1687E-3	13	63	2	6292
spindle pole body	7.1687E-3	13	63	2	6292
nucleus	7.1693E-3	13	2041	9	6292
spindle pole	8.3131E-3	13	68	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear-transcribed mRNA poly(A) tail shortening	1.7767E-19	13	8	7	6292
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	4.6478E-17	13	27	8	6292
nuclear-transcribed mRNA catabolic process	1.0158E-15	13	38	8	6292
mRNA 3'-end processing	5.7285E-14	13	31	7	6292
mRNA catabolic process	1.699E-13	13	69	8	6292
RNA 3'-end processing	5.8232E-13	13	42	7	6292
RNA catabolic process	5.8439E-13	13	80	8	6292
RNA elongation from RNA polymerase II promoter	6.3097E-11	13	39	6	6292
RNA elongation	1.5662E-10	13	45	6	6292
mRNA metabolic process	1.685E-9	13	213	8	6292
regulation of transcription, DNA-dependent	3.3081E-9	13	358	9	6292
regulation of RNA metabolic process	3.7419E-9	13	363	9	6292
regulation of transcription	6.1632E-9	13	384	9	6292
mRNA processing	7.6284E-9	13	156	7	6292
cellular macromolecule catabolic process	9.5606E-9	13	265	8	6292
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.2251E-8	13	415	9	6292
regulation of nitrogen compound metabolic process	1.2515E-8	13	416	9	6292
macromolecule catabolic process	2.171E-8	13	294	8	6292
regulation of gene expression	2.268E-8	13	445	9	6292
regulation of macromolecule biosynthetic process	2.812E-8	13	456	9	6292
regulation of cellular biosynthetic process	3.8084E-8	13	472	9	6292
regulation of biosynthetic process	3.8799E-8	13	473	9	6292
regulation of macromolecule metabolic process	5.1037E-8	13	488	9	6292
transcription, DNA-dependent	6.6555E-8	13	503	9	6292
RNA biosynthetic process	7.2579E-8	13	508	9	6292
regulation of primary metabolic process	8.0439E-8	13	514	9	6292
regulation of transcription from RNA polymerase II promoter	1.0672E-7	13	228	7	6292
regulation of cellular metabolic process	1.1605E-7	13	536	9	6292
regulation of metabolic process	1.3858E-7	13	547	9	6292
transcription	1.5003E-7	13	552	9	6292
regulation of cellular process	1.9902E-7	13	796	10	6292
regulation of biological process	2.7792E-7	13	824	10	6292
cellular catabolic process	3.2175E-7	13	415	8	6292
RNA metabolic process	1.136E-6	13	954	10	6292
catabolic process	1.2745E-6	13	496	8	6292
transcription from RNA polymerase II promoter	1.4817E-6	13	335	7	6292
RNA processing	3.4682E-6	13	380	7	6292
protein ubiquitination	6.9177E-6	13	65	4	6292
biological regulation	1.1099E-5	13	1213	10	6292
protein modification by small protein conjugation	2.1179E-5	13	86	4	6292
post-translational protein modification	3.9067E-5	13	357	6	6292
cellular macromolecule metabolic process	4.4721E-5	13	2285	12	6292
nucleic acid metabolic process	4.6755E-5	13	1415	10	6292
macromolecule metabolic process	6.1467E-5	13	2349	12	6292
protein modification by small protein conjugation or removal	6.4433E-5	13	114	4	6292
cellular macromolecule biosynthetic process	1.0105E-4	13	1187	9	6292
macromolecule biosynthetic process	1.0245E-4	13	1189	9	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.1898E-4	13	1566	10	6292
gene expression	1.9087E-4	13	1283	9	6292
protein modification process	2.5567E-4	13	499	6	6292
cellular nitrogen compound metabolic process	3.6181E-4	13	1770	10	6292
nitrogen compound metabolic process	4.023E-4	13	1791	10	6292
macromolecule modification	5.2532E-4	13	569	6	6292
primary metabolic process	6.6865E-4	13	2896	12	6292
cellular biosynthetic process	9.4785E-4	13	1567	9	6292
cellular metabolic process	1.1248E-3	13	3033	12	6292
biosynthetic process	1.1277E-3	13	1602	9	6292
metabolic process	1.7612E-3	13	3157	12	6292
conjugation with cellular fusion	1.8925E-3	13	125	3	6292
conjugation	1.9364E-3	13	126	3	6292
multi-organism process	2.7814E-3	13	143	3	6292
negative regulation of transcription from RNA polymerase II promoter	6.5197E-3	13	60	2	6292
regulation of mitotic cell cycle	9.0369E-3	13	71	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
3'-5'-exoribonuclease activity	5.3766E-15	13	23	7	6292
exoribonuclease activity, producing 5'-phosphomonoesters	1.439E-14	13	26	7	6292
exoribonuclease activity	1.439E-14	13	26	7	6292
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.169E-13	13	34	7	6292
3'-5' exonuclease activity	1.46E-13	13	35	7	6292
exonuclease activity	1.1514E-12	13	46	7	6292
ribonuclease activity	5.5287E-9	13	149	7	6292
nuclease activity	4.1642E-8	13	199	7	6292
hydrolase activity, acting on ester bonds	1.6709E-6	13	341	7	6292
ubiquitin-protein ligase activity	4.0734E-6	13	57	4	6292
small conjugating protein ligase activity	5.7195E-6	13	62	4	6292
acid-amino acid ligase activity	9.8594E-6	13	71	4	6292
hydrolase activity	1.1126E-5	13	911	9	6292
ligase activity, forming carbon-nitrogen bonds	3.0134E-5	13	94	4	6292
ligase activity	1.8764E-4	13	150	4	6292
catalytic activity	2.0237E-3	13	2150	10	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis