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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 240.20
Complex Size: 3 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
RPD3
  • histone deacetylase complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • protein amino acid deacetylation
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • chromatin organization
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • mitotic recombination
    		•
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
    		•
    SAP30
  • histone deacetylase complex
    		•
  • chromatin silencing at rDNA
  • telomere maintenance
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
    		•
  • histone deacetylase activity
    		•
    SIN3
  • Sin3 complex
  • histone deacetylase complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
    		•
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone deacetylase complex 4.2679E-8 3 23 3 6292
    chromatin remodeling complex 3.7798E-6 3 99 3 6292
    nucleoplasm part 5.8345E-5 3 245 3 6292
    nucleoplasm 7.3064E-5 3 264 3 6292
    nuclear lumen 3.709E-4 3 453 3 6292
    organelle lumen 1.1495E-3 3 660 3 6292
    intracellular organelle lumen 1.1495E-3 3 660 3 6292
    membrane-enclosed lumen 1.3717E-3 3 700 3 6292
    Sin3 complex 1.9063E-3 3 4 1 6292
    Sin3-type complex 2.3825E-3 3 5 1 6292
    nuclear part 5.3751E-3 3 1103 3 6292
    protein complex 5.8881E-3 3 1137 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    chromatin silencing at rDNA 1.9664E-8 3 18 3 6292
    histone deacetylation 7.0488E-8 3 27 3 6292
    protein amino acid deacetylation 8.8056E-8 3 29 3 6292
    chromatin silencing at silent mating-type cassette 1.3148E-7 3 33 3 6292
    chromatin silencing at telomere 6.3223E-7 3 55 3 6292
    covalent chromatin modification 2.6445E-6 3 88 3 6292
    histone modification 2.6445E-6 3 88 3 6292
    negative regulation of gene expression, epigenetic 3.8967E-6 3 100 3 6292
    gene silencing 3.8967E-6 3 100 3 6292
    regulation of gene expression, epigenetic 3.8967E-6 3 100 3 6292
    chromatin silencing 3.8967E-6 3 100 3 6292
    negative regulation of transcription, DNA-dependent 1.5247E-5 3 157 3 6292
    negative regulation of RNA metabolic process 1.5543E-5 3 158 3 6292
    negative regulation of transcription 1.7394E-5 3 164 3 6292
    negative regulation of gene expression 1.7394E-5 3 164 3 6292
    chromatin modification 1.8706E-5 3 168 3 6292
    negative regulation of macromolecule biosynthetic process 2.1158E-5 3 175 3 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.3035E-5 3 180 3 6292
    negative regulation of nitrogen compound metabolic process 2.3035E-5 3 180 3 6292
    negative regulation of biosynthetic process 2.6687E-5 3 189 3 6292
    negative regulation of cellular biosynthetic process 2.6687E-5 3 189 3 6292
    negative regulation of macromolecule metabolic process 2.7985E-5 3 192 3 6292
    chromatin organization 3.3104E-5 3 203 3 6292
    negative regulation of cellular metabolic process 3.6143E-5 3 209 3 6292
    negative regulation of metabolic process 3.6667E-5 3 210 3 6292
    double-strand break repair via nonhomologous end joining 4.5363E-5 3 25 2 6292
    negative regulation of cellular process 6.2006E-5 3 250 3 6292
    negative regulation of biological process 6.4274E-5 3 253 3 6292
    non-recombinational repair 8.4748E-5 3 34 2 6292
    post-translational protein modification 1.8121E-4 3 357 3 6292
    regulation of transcription, DNA-dependent 1.8274E-4 3 358 3 6292
    regulation of RNA metabolic process 1.9053E-4 3 363 3 6292
    regulation of transcription 2.2565E-4 3 384 3 6292
    double-strand break repair 2.4051E-4 3 57 2 6292
    negative regulation of transcription from RNA polymerase II promoter 2.6665E-4 3 60 2 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.85E-4 3 415 3 6292
    regulation of nitrogen compound metabolic process 2.8707E-4 3 416 3 6292
    regulation of gene expression 3.5155E-4 3 445 3 6292
    regulation of macromolecule biosynthetic process 3.7833E-4 3 456 3 6292
    regulation of cellular biosynthetic process 4.1966E-4 3 472 3 6292
    regulation of biosynthetic process 4.2234E-4 3 473 3 6292
    regulation of macromolecule metabolic process 4.639E-4 3 488 3 6292
    protein modification process 4.9605E-4 3 499 3 6292
    transcription, DNA-dependent 5.081E-4 3 503 3 6292
    RNA biosynthetic process 5.2344E-4 3 508 3 6292
    positive regulation of transcription from RNA polymerase II promoter 5.2382E-4 3 84 2 6292
    regulation of primary metabolic process 5.4224E-4 3 514 3 6292
    regulation of cellular metabolic process 6.1504E-4 3 536 3 6292
    regulation of metabolic process 6.5376E-4 3 547 3 6292
    transcription 6.7188E-4 3 552 3 6292
    chromosome organization 6.8292E-4 3 555 3 6292
    macromolecule modification 7.3601E-4 3 569 3 6292
    positive regulation of transcription, DNA-dependent 7.8773E-4 3 103 2 6292
    DNA metabolic process 7.9998E-4 3 585 3 6292
    positive regulation of RNA metabolic process 8.5005E-4 3 107 2 6292
    positive regulation of transcription 9.3124E-4 3 112 2 6292
    positive regulation of gene expression 9.3124E-4 3 112 2 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0335E-3 3 118 2 6292
    positive regulation of nitrogen compound metabolic process 1.0335E-3 3 118 2 6292
    positive regulation of macromolecule biosynthetic process 1.0335E-3 3 118 2 6292
    positive regulation of biosynthetic process 1.0866E-3 3 121 2 6292
    positive regulation of cellular biosynthetic process 1.0866E-3 3 121 2 6292
    positive regulation of macromolecule metabolic process 1.178E-3 3 126 2 6292
    positive regulation of metabolic process 1.2346E-3 3 129 2 6292
    positive regulation of cellular metabolic process 1.2346E-3 3 129 2 6292
    positive regulation of cellular process 1.3717E-3 3 136 2 6292
    positive regulation of biological process 1.3919E-3 3 137 2 6292
    regulation of cellular process 2.0181E-3 3 796 3 6292
    regulation of biological process 2.2389E-3 3 824 3 6292
    DNA repair 2.7234E-3 3 192 2 6292
    RNA metabolic process 3.4763E-3 3 954 3 6292
    regulation of transcription from RNA polymerase II promoter 3.8286E-3 3 228 2 6292
    response to DNA damage stimulus 4.0991E-3 3 236 2 6292
    loss of chromatin silencing involved in replicative cell aging 4.2857E-3 3 9 1 6292
    progressive alteration of chromatin involved in replicative cell aging 4.7611E-3 3 10 1 6292
    loss of chromatin silencing 4.7611E-3 3 10 1 6292
    cellular protein metabolic process 4.9618E-3 3 1074 3 6292
    progressive alteration of chromatin involved in cell aging 5.2364E-3 3 11 1 6292
    positive regulation of gene expression, epigenetic 5.2364E-3 3 11 1 6292
    regulation of gene silencing 5.2364E-3 3 11 1 6292
    negative regulation of gene silencing 5.2364E-3 3 11 1 6292
    regulation of chromatin silencing 5.2364E-3 3 11 1 6292
    negative regulation of chromatin silencing 5.2364E-3 3 11 1 6292
    organelle organization 5.734E-3 3 1127 3 6292
    protein metabolic process 5.8726E-3 3 1136 3 6292
    anatomical structure homeostasis 5.9917E-3 3 286 2 6292
    telomere organization 5.9917E-3 3 286 2 6292
    telomere maintenance 5.9917E-3 3 286 2 6292
    cellular response to stress 6.1581E-3 3 290 2 6292
    cellular macromolecule biosynthetic process 6.7003E-3 3 1187 3 6292
    macromolecule biosynthetic process 6.7343E-3 3 1189 3 6292
    biological regulation 7.1507E-3 3 1213 3 6292
    transcription from RNA polymerase II promoter 8.1809E-3 3 335 2 6292
    gene expression 8.4626E-3 3 1283 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone deacetylase activity 1.1953E-7 3 32 3 6292
    protein deacetylase activity 1.1953E-7 3 32 3 6292
    deacetylase activity 1.5773E-7 3 35 3 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 4.1681E-7 3 48 3 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 1.9799E-6 3 80 3 6292
    transcription corepressor activity 1.8163E-5 3 16 2 6292
    transcription coactivator activity 3.1768E-5 3 21 2 6292
    transcription cofactor activity 1.1776E-4 3 40 2 6292
    transcription factor binding 1.3628E-4 3 43 2 6292
    transcription repressor activity 1.4276E-4 3 44 2 6292
    transcription activator activity 2.7566E-4 3 61 2 6292
    hydrolase activity 3.0267E-3 3 911 3 6292
    transcription regulator activity 8.374E-3 3 339 2 6292
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