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Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. Progression of the cell from its inception to the end of its lifespan. Any process by which extrachromosomal circular DNA molecules are transported to, or maintained in, a specific location in cells contributing to their aging. The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility. Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication. The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype. The process by which changes in chromatin structure contributing to replicative cell aging occurs. The process by which changes in chromatin structure contributing to chronological cell aging occur in non-dividing cells. The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: progressive alteration of chromatin involved in cell aging
Acc: GO:0001301
Aspect: Biological Process
Desc: The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype.
Synonyms:
  • progressive alteration of chromatin during cell ageing
  • progressive alteration of chromatin during cell aging
  • age-dependent accumulation of genetic damage
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 18 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0001301 - progressive alteration of chromatin involved in cell aging (interactive image map)
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