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Protein Overview: MYO5

General Information:
Name(s) found: MYO5 / YMR109W [SGD]
Description(s) found:
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  • gi|817867|emb|CAA89745.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323756|ref|NP_013827.1| One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organizatio [NCBI NR]
  • gi|2498024|sp|Q04439.1|MYO5_YEAST RecName: Full=Myosin-5; AltName: Full=Class I unconventional myosin MYO5; AltName: Full=Type I myosin MYO5; AltName: Full=Actin-dependent myosin-I MYO5 [NCBI NR]
  • gi|1699241|gb|AAB37419.1| Myo5p=actin patch localized myosin I variant/MYO5 product [Saccharomyces cerevisiae=yeast, Peptide, 1219 aa] [NCBI NR]
  • pir||S54570 probable membrane protein YMR109w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • (Q04439) Myosin-5 isoform [Swiss-Prot]
  • Myosin-5 OS=Saccharomyces cerevisiae GN=MYO5 PE=1 SV=1 [Swiss-Prot]
  • MYO5 Myosin I [mips]
  • One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [SGD]
  • MYO5, Chr XIII from 486586-490245 [yeast_orfs2]
  • Chr XIII from 486586-490245 [yeastorf3.fasta]
  • MYO5 SGDID:S0004715, Chr XIII from 486586-490245, Verified ORF [yeastflysequest.fasta]
  • Myo5p [Saccharomyces cerevisiae]gi|817867|emb|CAA89745.1| unknown [Saccharomyces cerevisiae]gi|2498024|sp|Q04439|MYS5_YEAST Myosin-5 isoformgi|1699241|gb|AAB37419.1| Myo5p=actin patch localized myosin I variant/MYO5 product [Saccharomyces cerevisiae=ye [nrdb_11152004_Chlamydomonas]
  • MYO5 SGDID:S000004715, Chr XIII from 486586-490245, Verified ORF, "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in gr [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Myo5p=actin patch localized myosin I variant/MYO5 product [Saccharomyces cerevisiae=yeast, Peptide, 1219 aa] [nr-271106-contam.fasta]
  • One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; Myo5p [Saccharomyces cere [nr-271106-contam.fasta]
  • Myosin-5 [nr-271106-contam.fasta]
  • MYO5 SGDID:S000004715, Chr XIII from 486586-490245, Verified ORF, "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Myosin-5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MYO5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MYO5 SGDID:S000004715, Chr XIII from 486587-490246, Genome Release 64-1-1, Verified ORF, "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization" [yeast-030211-contam.fasta]
  • MYO5 SGDID:S000004715, Chr XIII from 486587-490246, Genome Release 64-2-1, Verified ORF, "One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YMR109W SGDID:S000004715, Chr XIII from 486587-490246, Genome Release 64-1-1, Verified ORF, "One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1219 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: response to salt stress [IGILink to PubMed article][IPILink to PubMed article]
    bipolar cellular bud site selection [IMPLink to PubMed article]
    response to osmotic stress [IMPLink to PubMed article]
    cellular cell wall organization [IMPLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    exocytosis [IMPLink to PubMed article]
    Molecular Function: microfilament motor activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAILKRGARK KVHQEPAKRS ANIKKATFDS SKKKEVGVSD LTLLSKISDE AINENLKKRF  60
   61 LNATIYTYIG HVLISVNPFR DLGIYTDAVM NEYKGKNRLE VPPHVFAIAE SMYYNMKSYN 120
  121 ENQCVIISGE SGAGKTEAAK RIMQYIAAAS STHTESIGKI KDMVLATNPL LESFGCAKTL 180
  181 RNNNSSRHGK YLEIKFNNQF EPCAGNITNY LLEKQRVVSQ IKNERNFHIF YQFTKGASDA 240
  241 YRQTFGVQKP EQYVYTAAAG CISAETIDDL QDYQETLKAM RVIGLGQEEQ DQIFRMLAAI 300
  301 LWIGNVSFIE NEEGNAQVRD TSVTDFVAYL LQIDSQLLIK SLVERIMETN HGMKRGSVYH 360
  361 VPLNIVQADA VRDALAKAIY NNLFDWIVSR VNKSLQAFPG AEKSIGILDI YGFEIFEHNS 420
  421 FEQICINYVN EKLQQIFIQL TLKSEQETYE REKIQWTPIK YFDNKVVCDL IEARRPPGIF 480
  481 AAMNDSVATA HADSNAADQA FAQRLNLFTT NPHFDLRSNK FVIKHYAGDV TYDIDGITDK 540
  541 NKDQLQKDLV ELIGTTTNTF LATIFPDTVD RESKRRPPTA GDKIIKSAND LVETLSKAQP 600
  601 SYIRTIKPNE TKSPNDYDDR QVLHQIKYLG LQENVRIRRA GFAYRQVFEK FVERFYLLSP 660
  661 HCSYAGDYTW QGDTLDAVKY ILQDSSIPQQ EYQLGVTSVF IKTPETLFAL EHMRDRYWHN 720
  721 MAARIQRAWR RFLQRRIDAA TKIQRTIRER KEGNKYEKLR DYGTKVLGGR KERRSMSLLG 780
  781 YRAFMGDYLS CNESKSKGAY IKRQVSIKEK VIFSIHGEAL HTKFGRSAQR LKKTFLLTPT 840
  841 TLYIVGQTLV QNAMTYTQDY KIDVRNIQAV SLTNLQDDWV AIKLASSGQP DPLINTYFKT 900
  901 ELITHLKRLN DKIQIKIGSA IEYQKKPGKL HSVKCQINES APKYGDIYKS STISVRRGNP 960
  961 PNSQVHKKPR KKSSISSGYH ASSSQATRRP VSIAAAQHVP TAPASRHSKK PAPPPPGMQN1020
 1021 KAATRRSVPN PASTLTASQS NARPSPPTAA TRATPAATPA AAAMGSGRQA NIPPPPPPPP1080
 1081 PSSKPKEPMF EAAYDFPGSG SPSELPLKKG DVIYITREEP SGWSLGKLLD GSKEGWVPTA1140
 1141 YMKPHSGNNN IPTPPQNRDV PKPVLNSVQH DNTSANVIPA AAQASLGDGL ANALAARANK1200
 1201 MRLESDDEEA NEDEEEDDW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CMD1 MYO5 YGL242C
    View Details (MIPS) Mewes HW, et al. (2004) MYO1 MYO2 MYO3 MYO4 MYO5 SMY1 SMY2
    View Details Krogan NJ, et al. (2006) CMD1 CMK1 CMK2 CMP2 CNA1 CNB1 MYO3 MYO5 YGL242C
    View Details Gavin AC, et al. (2006) MCM7 MYO5
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Ho Y, et al. (2002) CMD1 CMK2 CMP2 COF1 CPR1 EDE1 HCH1 HUL5 HYP2 ILS1 IPP1 MLC1 MYO2 MYO3 MYO4 MYO5 PGM2 PST2 SHE3 SHE4 SOD1 SPC110 UBA1 VAS1 VPS13 YNK1
    View Details Qiu et al. (2008) ABP1 ACT1 AIP1 ARC40 BZZ1 CAP2 CRN1 DYN1 INP53 LAS17 MYO1 MYO2 MYO3 MYO4 MYO5 PAN1 RVS167 SAC6 SLA1 SLA2 SRV2 TWF1 VRP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MYO5 and SAC6 Huh WK, et al. (2003)
    View Data MYO5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..642] PSI-BLAST 2660.0 Myosin S1, motor domain
    2 View Details [643..714] PSI-BLAST 2660.0 Myosin S1, motor domain
    3 View Details [715..768] PSI-BLAST 12.69897 SCALLOP MYOSIN REGULATORY DOMAIN
    4 View Details [769..842] PSI-BLAST 4.39794 Tropomyosin
    5 View Details [843..905] PSI-BLAST 4.39794 Tropomyosin
    6 View Details [906..957] PSI-BLAST 4.39794 Tropomyosin
    7 View Details [958..1070] ab initio 8.21 No description for 1ldvA was found.
    8 View Details [1071..1167] PSI-BLAST 2.30103 INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
    9 View Details [1168..1219] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle