Protein Overview: ILV5

General Information:
Name(s) found:	ILV5 / YLR355C [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|A24709 ketol-acid reductoisomerase (EC 1.1.1.86) ILV5 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6323387\|ref\|NP_013459.1\| Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids; Ilv5p [Saccharomyce [NCBI NR] gi\|609403\|gb\|AAB67753.1\| Ilv5p: acetohydroxyacid reductoisomerase [Saccharomyces cerevisiae] [NCBI NR] gi\|3827\|emb\|CAA28643.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|124371\|sp\|P06168.1\|ILV5_YEAST RecName: Full=Ketol-acid reductoisomerase, mitochondrial; AltName: Full=Acetohydroxy-acid reductoisomerase; AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase; Flags: Precursor [NCBI NR] Ketol-acid reductoisomerase, mitochondrial OS=Saccharomyces cerevisiae GN=ILV5 PE=1 SV=1 [Swiss-Prot] ILV5 Ketol-acid reducto-isomerase [mips] Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids [SGD] ILV5, Chr XII from 838065-839252, reverse complement [yeast_orfs2] Chr XII from 838065-839252, reverse complement [yeastorf3.fasta] Chr XII from 839252-838065, reverse complement [yeastorf5.fasta] (P06168) Ketol-acid reductoisomerase, mitochondrial precursor (EC 1.1.1.86) (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacil reductoisomerase) [4932.FASTACCERV.txt] ILV5 SGDID:S0004347, Chr XII from 839252-838065, reverse complement, Verified ORF [yeastflysequest.fasta] Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA [Saccharomyces cerevisiae]gi\|3827\|emb\|CAA28643.1\| unnamed protein product [Saccharom [nrdb_11152004_Chlamydomonas] ILV5 SGDID:S000004347, Chr XII from 839252-838065, reverse complement, Verified ORF, "Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ketol-acid reductoisomerase, mitochondrial precursor (Acetohydroxy-acid reductoisomerase) (Alpha-keto-beta-hydroxylacil reductoisomerase) [nr-271106-contam.fasta] Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA; Ilv5p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ilv5p: acetohydroxyacid reductoisomerase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ILV5 SGDID:S000004347, Chr XII from 839252-838065, reverse complement, Verified ORF, "Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids" [yeast-bovrabprots.fasta] ILV5 SGDID:S000004347, Chr XII from 839252-838065, reverse complement, Verified ORF, "Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA" [yeast-contam_custom.fasta] [chemostatdb.fasta] Ketol-acid reductoisomerase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV5 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ILV5 SGDID:S000004347, Chr XII from 839253-838066, Genome Release 64-1-1, reverse complement, Verified ORF, "Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids" [yeast-030211-contam.fasta] ILV5 SGDID:S000004347, Chr XII from 839253-838066, Genome Release 64-2-1, reverse complement, Verified ORF, "Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids" [20141208_orf_trans.fasta] TR4035\|c0_g1_i1\|g.2852 ORF TR4035\|c0_g1_i1\|g.2852 TR4035\|c0_g1_i1\|m.2852 type:complete len:396 (+) TR4035\|c0_g1_i1:84-1271(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR8791\|c0_g1_i1\|g.6227 ORF TR8791\|c0_g1_i1\|g.6227 TR8791\|c0_g1_i1\|m.6227 type:complete len:396 (+) TR8791\|c0_g1_i1:87-1274(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YLR355C SGDID:S000004347, Chr XII from 839253-838066, Genome Release 64-1-1, reverse complement, Verified ORF, "Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_7056\|g.5456 ORF asmbl_7056\|g.5456 asmbl_7056\|m.5456 type:complete len:396 (+) asmbl_7056:82-1269(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_7734\|g.5704 ORF asmbl_7734\|g.5704 asmbl_7734\|m.5704 type:complete len:396 (+) asmbl_7734:82-1269(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_7041\|g.4430 ORF ID=asmbl_7041\|g.4430 ID=asmbl_7041\|m.4430 type:complete len:396 (+) ID=asmbl_7041:82-1269(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_7512\|g.4706 ORF ID=asmbl_7512\|g.4706 ID=asmbl_7512\|m.4706 type:complete len:396 (+) ID=asmbl_7512:82-1269(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	395 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA ][TAS] mitochondrial nucleoid [IDA]
Biological Process:	branched chain family amino acid biosynthetic process [TAS] mitochondrial genome maintenance [IMP]
Molecular Function:	ketol-acid reductoisomerase activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRTQAARLI CNSRVITAKR TFALATRAAA YSRPAARFVK PMITTRGLKQ INFGGTVETV  60
   61 YERADWPREK LLDYFKNDTF ALIGYGSQGY GQGLNLRDNG LNVIIGVRKD GASWKAAIED 120
  121 GWVPGKNLFT VEDAIKRGSY VMNLLSDAAQ SETWPAIKPL LTKGKTLYFS HGFSPVFKDL 180
  181 THVEPPKDLD VILVAPKGSG RTVRSLFKEG RGINSSYAVW NDVTGKAHEK AQALAVAIGS 240
  241 GYVYQTTFER EVNSDLYGER GCLMGGIHGM FLAQYDVLRE NGHSPSEAFN ETVEEATQSL 300
  301 YPLIGKYGMD YMYDACSTTA RRGALDWYPI FKNALKPVFQ DLYESTKNGT ETKRSLEFNS 360
  361 QPDYREKLEK ELDTIRNMEI WKVGKEVRKL RPENQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ILV1 ILV5
View Details	Gavin AC, et al. (2006)		ARO3 ILV5 TDH1
View Details	Ho Y, et al. (2002)		AAC3 ADH2 ADH5 ADH6 AHA1 AHP1 ARP2 BCK1 CAR2 CNS1 COR1 CPR6 CYS4 DED1 ECM10 EGD2 FOL2 GAL7 GAS1 GND1 GYP5 HEM15 HHF1, HHF2 HYP2 IDH1 ILV5 IPP1 KIC1 KIN2 LCD1 LHS1 LYS12 MET18 MKK2 MKT1 MPC54 OYE2 OYE3 PDC6 PHO84 PIL1 PMA1 POR1 PRE10 PST2 PYC2 QCR2 RCN2 RNQ1 RNR2 RPN6 RPT3 RVS167 SAH1 SES1 SIR1 SIR3 SIS1 SKG3 SLT2 SMK1 SOD1 TEF4 TIF1, TIF2 TMA29 URA7 YBL108W YCK1 YHB1 YHR112C YLR243W
View Details	Qiu et al. (2008)		IDP1 ILV5 LPD1 RPO41 YHM2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	BIR1	No Comments	Widlund PO, et al. (2005)
View Run	DAD1	Dam1-765 complex purified from yeast with Dad1-TAP	Shimogawa MM, et al. (2006)
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ILV5	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..395]	PSI-BLAST	448.211549	Class II ketol-acid reductoisomerase; Class II ketol-acid reductoisomerase (KARI)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.69

Protein Overview: ILV5

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: