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Protein Overview: MCR1

General Information:
Name(s) found: MCR1 / YKL150W [SGD]
Description(s) found:
Found 29 descriptions.
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  • Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 302 amino acids

    Gene Ontology:
    Cellular Component: integral to mitochondrial outer membrane [IDALink to PubMed article]
    mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article]
    Biological Process: response to oxidative stress [IMPLink to PubMed article]
    electron transport [IDALink to PubMed article]
    ergosterol biosynthetic process [IDALink to PubMed article]
    Molecular Function: cytochrome-b5 reductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRLSRSHS KALPIALGTV AIAAATAFYF ANRNQHSFVF NESNKVFKGD DKWIDLPISK  60
   61 IEEESHDTRR FTFKLPTEDS EMGLVLASAL FAKFVTPKGS NVVRPYTPVS DLSQKGHFQL 120
  121 VVKHYEGGKM TSHLFGLKPN DTVSFKGPIM KWKWQPNQFK SITLLGAGTG INPLYQLAHH 180
  181 IVENPNDKTK VNLLYGNKTP QDILLRKELD ALKEKYPDKF NVTYFVDDKQ DDQDFDGEIS 240
  241 FISKDFIQEH VPGPKESTHL FVCGPPPFMN AYSGEKKSPK DQGELIGILN NLGYSKDQVF 300
  301 KF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ADK1 ATP3 ATP5 ATP7 CDC14 DPM1 FUR1 GLC7 HEF3 HMS1 MCR1 SNF4 SPE3 SSZ1 TPS1 TSA2 VAS1
    View Details Qiu et al. (2008) ALO1 ATP15 ATP2 ATP4 AYR1 CCP1 COB COR1 COX1 COX2 COX3 COX4 COX5A COX5B COX6 COX7 COX8 COX9 CYB2 CYC1 CYC7 CYT1 ERV1 MCR1 POR1 QCR10 QCR2 QCR7 QCR8 QCR9 RIP1 SDH2 SDH3 SDH4 TAZ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run NAF1 No Comments Hazbun TR, et al. (2003)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen HMT1 MCR1 1 Unpublished Fields Lab Data
    View Screen UBC6 MCR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MCR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 407.67837 cytochrome b5 reductase
    2 View Details [149..302] PSI-BLAST 407.67837 cytochrome b5 reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on NADH or NADPH
    		•  5.12164086042432 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  4.82719560919736 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  4.10258111244259 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  3.98767523940821 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  3.81212227280399 bayes_pls_golite062009
  • coenzyme binding
    		•  3.33805077160148 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
    		•  3.111558299994 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.02740987944465 bayes_pls_golite062009
  • FAD binding
    		•  2.07600122867642 bayes_pls_golite062009
  • binding
    		•  1.6140200001643 bayes_pls_golite062009
  • arginine binding
    		•  1.58854105635357 bayes_pls_golite062009
  • cytochrome-b5 reductase activity
    		•  1.5685421124725 bayes_pls_golite062009
  • ferredoxin reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • ferredoxin-NADP+ reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
    		•  1.46342400843015 bayes_pls_golite062009
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • tetrahydrobiopterin binding
    		•  1.29331444558985 bayes_pls_golite062009
  • NADP or NADPH binding
    		•  1.18833847639357 bayes_pls_golite062009
  • demethylase activity
    		•  1.1768217851058 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.90349352746963 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors
    		•  0.73475657802914 bayes_pls_golite062009
  • transferase activity
    		•  0.708491789248912 bayes_pls_golite062009
  • FMN binding
    		•  0.649158247260553 bayes_pls_golite062009
  • protein binding
    		•  0.452115023569428 bayes_pls_golite062009
  • riboflavin synthase activity
    		•  0.380537461428523 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  0.33163571415742 bayes_pls_golite062009
  • cofactor binding
    		•  0.205324283520452 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle