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View Structure Prediction Details

Protein: MCR1
Organism: Saccharomyces cerevisiae
Length: 302 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCR1.

Description E-value Query
Range		 Subject
Range
gi|484212 - gi|484212|gb|AAA33712.1| nitrate reductase apoenzyme
 2.0E-77 [2..302] [595..915]
NIA2_TOBAC - Nitrate reductase [NADH] 2 OS=Nicotiana tabacum GN=NIA2 PE=2 SV=2
 7.0E-76 [2..302] [585..904]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 8.0E-76 [2..302] [585..904]
gi|11119241 - gi|11119241|gb|AAG30576.1|AF314093_1 nitrate reductase [Ricinus communis]
 7.0E-75 [2..302] [588..914]
gi|14041825 - gi|14041825|dbj|BAB55002.1| nitrate reductase [Prunus persica]
 8.0E-75 [2..302] [578..906]
NIA_LOTJA - Nitrate reductase [NADH] OS=Lotus japonicus GN=NIA PE=3 SV=1
 8.0E-75 [2..302] [575..900]
NIA_SOLLC - Nitrate reductase [NADH] OS=Solanum lycopersicum GN=NIA PE=3 SV=1
 1.0E-74 [2..302] [590..911]
NIA2_PHAVU - Nitrate reductase [NADH] 2 OS=Phaseolus vulgaris GN=NIA2 PE=3 SV=1
 1.0E-74 [2..302] [567..890]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-74 [2..302] [585..904]

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Predicted Domain #1
Region A:
Residues: [1-148] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSRLSRSHS KALPIALGTV AIAAATAFYF ANRNQHSFVF NESNKVFKGD DKWIDLPISK  60
   61 IEEESHDTRR FTFKLPTEDS EMGLVLASAL FAKFVTPKGS NVVRPYTPVS DLSQKGHFQL 120
  121 VVKHYEGGKM TSHLFGLKPN DTVSFKGP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 407.67837
Match: 1ib0A_
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity, acting on NADH or NADPH 5.12164086042432 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 4.82719560919736 bayes_pls_golite062009
NADH dehydrogenase activity 4.10258111244259 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 3.98767523940821 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 3.81212227280399 bayes_pls_golite062009
coenzyme binding 3.33805077160148 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor 3.111558299994 bayes_pls_golite062009
oxidoreductase activity 3.02740987944465 bayes_pls_golite062009
FAD binding 2.07600122867642 bayes_pls_golite062009
binding 1.6140200001643 bayes_pls_golite062009
arginine binding 1.58854105635357 bayes_pls_golite062009
cytochrome-b5 reductase activity 1.5685421124725 bayes_pls_golite062009
ferredoxin reductase activity 1.46342400843015 bayes_pls_golite062009
ferredoxin-NADP+ reductase activity 1.46342400843015 bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor 1.46342400843015 bayes_pls_golite062009
catalytic activity 1.45374095556065 bayes_pls_golite062009
tetrahydrobiopterin binding 1.29331444558985 bayes_pls_golite062009
NADP or NADPH binding 1.18833847639357 bayes_pls_golite062009
demethylase activity 1.1768217851058 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 0.90349352746963 bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors 0.73475657802914 bayes_pls_golite062009
transferase activity 0.708491789248912 bayes_pls_golite062009
FMN binding 0.649158247260553 bayes_pls_golite062009
protein binding 0.452115023569428 bayes_pls_golite062009
riboflavin synthase activity 0.380537461428523 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.33163571415742 bayes_pls_golite062009
cofactor binding 0.205324283520452 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [149-302] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMKWKWQPNQ FKSITLLGAG TGINPLYQLA HHIVENPNDK TKVNLLYGNK TPQDILLRKE  60
   61 LDALKEKYPD KFNVTYFVDD KQDDQDFDGE ISFISKDFIQ EHVPGPKEST HLFVCGPPPF 120
  121 MNAYSGEKKS PKDQGELIGI LNNLGYSKDQ VFKF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 407.67837
Match: 1ib0A_
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle