Protein Overview: PRP21

General Information:
Name(s) found:	PRP21 / YJL203W [SGD]
Description(s) found: Found 24 descriptions. SHOW ALL	Subunit of the SF3a splicing factor complex, required for spliceosome assembly [SGD]
Organism:	Saccharomyces cerevisiae
Length:	280 amino acids
Gene Ontology:
Cellular Component:	U2 snRNP [IDA ]
Biological Process:	nuclear mRNA splicing, via spliceosome [IDA]
Molecular Function:	RNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPEDTQLKE DIKTTVNYIK QHGVEFENKL LEDERFSFIK KDDPLHEYYT KLMNEPTDTV  60
   61 SGEDNDRKSE REIARPPDFL FSQYDTGISR RDMEVIKLTA RYYAKDKSIV EQMISKDGEA 120
  121 RLNFMNSSHP LHKTFTDFVA QYKRVYSFTG QEIKKSKRTI LDNCFERTQY WEFEKDKDRE 180
  181 HDKLVELCKI QFAAIPWDKF TQVAKFSIPE DTEIFEGSLD LEQMRLRRVQ TGIKLFDSIK 240
  241 PTNEEEKIVS DQGKQKGGDS KGKKRKIRAV GETRLKKSKK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRR2 CLF1 CUS1 DIB1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP19 PRP21 PRP3 PRP31 PRP4 PRP46 PRP6 PRP8 PRP9 RSE1 SMB1 SMD1 SMD2 SMD3 SNU114 SNU23 SNU66 STO1
View Details	(MIPS) Mewes HW, et al. (2004)		PRP19 PRP21 SNT309
View Details	Krogan NJ, et al. (2006)		BUD13 BUD31 CUS1 CWC21 HSH155 HSH49 LEA1 LOT6 PRP11 PRP21 PRP45 PRP9 RSE1
View Details	Gavin AC, et al. (2006)		BRR2 CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP3 PRP31 PRP4 PRP6 PRP8 PRP9 RSE1 SMB1 SNU114 SNU23 SNU66 SPP381
View Details	Gavin AC, et al. (2002)		AAR2 BRR1 BUD31 CBC2 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 ISY1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
View Details	Qiu et al. (2008)		AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 DHR2 HSH155 HSH49 ISY1 LEA1 LSM2 LSM4 LUC7 MAK5 MSL1 MUD1 MUD2 PRP11 PRP16 PRP18 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNT309 SNU114 SNU23 SNU66 SNU71 SPP381 STO1 SYF2 YHC1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PRP11	PRP21	2	Uetz P, et al. (2000)
View Screen	PRP21	MBB1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PRP21	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..75]	Pfam	13.920819	Surp module No confident structure predictions are available.
2	View Details	[76..208]	Pfam	14.468521	Surp module No confident structure predictions are available.
3	View Details	[209..280]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2