Protein Overview: ERG20

General Information:
Name(s) found:	ERG20 / YJL167W [SGD]
Description(s) found: Found 32 descriptions. SHOW ALL	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	352 amino acids
Gene Ontology:
Cellular Component:	cytosol [TAS]
Biological Process:	ergosterol biosynthetic process [TAS] isoprenoid biosynthetic process [IDA] farnesyl diphosphate biosynthetic process [IDA]
Molecular Function:	geranyltranstransferase activity [IDA][TAS] dimethylallyltranstransferase activity [IDA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASEKEIRRE RFLNVFPKLV EELNASLLAY GMPKEACDWY AHSLNYNTPG GKLNRGLSVV  60
   61 DTYAILSNKT VEQLGQEEYE KVAILGWCIE LLQAYFLVAD DMMDKSITRR GQPCWYKVPE 120
  121 VGEIAINDAF MLEAAIYKLL KSHFRNEKYY IDITELFHEV TFQTELGQLM DLITAPEDKV 180
  181 DLSKFSLKKH SFIVTFKTAY YSFYLPVALA MYVAGITDEK DLKQARDVLI PLGEYFQIQD 240
  241 DYLDCFGTPE QIGKIGTDIQ DNKCSWVINK ALELASAEQR KTLDENYGKK DSVAEAKCKK 300
  301 IFNDLKIEQL YHEYEESIAK DLKAKISQVD ESRGFKADVL TAFLNKVYKR SK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AAT2 ACH1 ACO1 ACS2 ADE3 ADE6 ADH4 ADH6 ADO1 AHP1 ALA1 APE2 ARA1 ARG4 ATG5 BAT1 BIO3 CAR2 CDC10 CDC16 CDC33 CDC60 CLU1 CPR1 CYS3 DED81 DPS1 ECM10 ENP1 ERG10 ERG20 FET3 GCY1 GDI1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MAM33 MDH1 MDH3 MPC54 MRE11 NAS6 OLA1 PAB1 PDC5 PFK2 PGM2 PMI40 PRP6 PTC7 QCR2 RAD26 RAD3 RAD50 RHR2 SAC6 SCP160 SEC53 SOD1 SSZ1 SUI1 TEF4 TFP1 THR4 TIF1, TIF2 TMA29 TPS1 TRR1 UBA1 XRS2 YDL124W YSP2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TWF1	ERG20	1	Unpublished Fields Lab Data
View Screen	YLR224W	ERG20	1	Unpublished Fields Lab Data
View Screen	APC5	ERG20	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ERG20	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..168] [199..218]	PSI-BLAST	976.0103	Farnesyl diphosphate synthase
2	View Details	[169..191] [238..314]	PSI-BLAST	976.0103	Farnesyl diphosphate synthase
3	View Details	[192..198] [219..237] [315..352]	PSI-BLAST	976.0103	Farnesyl diphosphate synthase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.90

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2