Protein Overview: CDC36

General Information:
Name(s) found:	CDC36 / YDL165W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|RGBY36 cell division control protein CDC36 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6320036\|ref\|NP_010116.1\| Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Cdc36p [Saccharomyces cerevisiae] [NCBI NR] gi\|577610\|emb\|CAA48160.1\| CDC36 [Saccharomyces cerevisiae] [NCBI NR] gi\|45269181\|gb\|AAS55970.1\| YDL165W [Saccharomyces cerevisiae] [NCBI NR] gi\|3516\|emb\|CAA27006.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|3491\|emb\|CAA27835.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|224010\|prf\|\|1007200A CDC36 gene [NCBI NR] gi\|1431262\|emb\|CAA98739.1\| CDC36 [Saccharomyces cerevisiae] [NCBI NR] gi\|115930\|sp\|P06100.1\|NOT2_YEAST RecName: Full=General negative regulator of transcription subunit 2 [NCBI NR] gi\|1061274\|emb\|CAA91581.1\| CDC36 protein [Saccharomyces cerevisiae] [NCBI NR] General negative regulator of transcription subunit 2 OS=Saccharomyces cerevisiae GN=NOT2 PE=1 SV=1 [Swiss-Prot] CDC36 Transcription factor [mips] Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [SGD] CDC36, Chr IV from 164291-164866 [yeast_orfs2] Chr IV from 164291-164866 [yeastorf3.fasta] (P06100) General negative regulator of transcription subunit 2 [4932.FASTACCERV.txt] CDC36 SGDID:S0002324, Chr IV from 164291-164866, Verified ORF [yeastflysequest.fasta] Cdc36p [Saccharomyces cerevisiae]gi\|577610\|emb\|CAA48160.1\| CDC36 [Saccharomyces cerevisiae]gi\|3491\|emb\|CAA27835.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1431262\|emb\|CAA98739.1\| CDC36 [Saccharomyces cerevisiae]gi\|3516\|emb\|CAA27006.1\| unn [nrdb_11152004_Chlamydomonas] CDC36 SGDID:S000002324, Chr IV from 164291-164866, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription fac [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor; Cdc36p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC36 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] General negative regulator of transcription subunit 2 [nr-271106-contam.fasta] YDL165W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC36 protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC36 gene [nr-271106-contam.fasta] CDC36 SGDID:S000002324, Chr IV from 164291-164866, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" [yeast-bovrabprots.fasta] [chemostatdb.fasta] General negative regulator of transcription subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC36 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC36 SGDID:S000002324, Chr IV from 164290-164865, Genome Release 64-1-1, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" [yeast-030211-contam.fasta] CDC36 SGDID:S000002324, Chr IV from 164290-164865, Genome Release 64-2-1, Verified ORF, "Component of the CCR4-NOT core complex; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor" [20141208_orf_trans.fasta] YDL165W SGDID:S000002324, Chr IV from 164290-164865, Genome Release 64-1-1, Verified ORF, "Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_508,ID=asmbl_523\|g.711 ORF ID=asmbl_508,ID=asmbl_523\|g.711 ID=asmbl_508,ID=asmbl_523\|m.711 type:complete len:192 (+) ID=asmbl_508,ID=asmbl_523:16477-17052(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	191 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] CCR4-NOT core complex [IPI]
Biological Process:	negative regulation of transcription from RNA polymerase II promoter [TAS] response to pheromone involved in conjugation with cellular fusion [IMP] nuclear-transcribed mRNA poly(A) tail shortening [IDA] nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA][IGI][IMP] regulation of transcription from RNA polymerase II promoter [IPI] RNA elongation from RNA polymerase II promoter [IMP] protein ubiquitination [IMP]
Molecular Function:	ubiquitin-protein ligase activity [IMP] 3'-5'-exoribonuclease activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKFGLKALV PLLKLEDKEL SSTYDHSMTL GADLSSMLYS LGIPRDSQDH RVLDTFQSPW  60
   61 AETSRSEVEP RFFTPESFTN IPGVLQSTVT PPCFNSIQND QQRVALFQDE TLFFLFYKHP 120
  121 GTVIQELTYL ELRKRNWRYH KTLKAWLTKD PMMEPIVSAD GLSERGSYVF FDPQRWEKCQ 180
  181 RDFLLFYNAI M

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC36 NOT5
View Details	(MIPS) Mewes HW, et al. (2004)		CAF16 CAF4 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2
View Details	Gavin AC, et al. (2006)		CDC36 MRD1 RPS10B
View Details	Gavin AC, et al. (2002)		AHA1 ATP11 CAF130 CAF40 CCR4 CCT6 CDC36 CDC39 COP1 FAS2 GCN1 MOT2 NOT3 NOT5 PDC1 POL1 POL12 POP2 PRI1 PRI2 RVB2 SAM1 SEC27 TFC7 TFP1 YRA1
View Details	Ho Y, et al. (2002)		CCR4 CDC36 CDC39 CYS4 PIL1 POP2 RNQ1 RVB1 STI1 UBR1
View Details	Qiu et al. (2008)		CAF16 CAF4 CAF40 CCR4 CDC36 CDC39 DBF2 DHH1 IBA57 MOB1 MOT2 NOT3 NOT5 POP2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 3 - cpn + atp, from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YJL147C	CDC36	2	Unpublished Fields Lab Data
View Screen	SOG2	CDC36	2	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	CDC36	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..191]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2