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Protein Overview: CCT4

General Information:
Name(s) found: CCT4 / YDL143W [SGD]
Description(s) found:
Found 21 descriptions.
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  • Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 528 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IPILink to PubMed article][TASLink to PubMed articleLink to PubMed article]
    cytoskeleton [TASLink to PubMed article]
    cytoplasm [TASLink to PubMed article]
    Biological Process: cytoskeleton organization [TASLink to PubMed article]
    protein folding [TASLink to PubMed article]
    Molecular Function: unfolded protein binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKVPSNAT FKNKEKPQEV RKANIIAARS VADAIRTSLG PKGMDKMIKT SRGEIIISND  60
   61 GHTILKQMAI LHPVARMLVE VSAAQDSEAG DGTTSVVILT GALLGAAERL LNKGIHPTII 120
  121 ADSFQSAAKR SVDILLEMCH KVSLSDREQL VRAASTSLSS KIVSQYSSFL APLAVDSVLK 180
  181 ISDENSKNVD LNDIRLVKKV GGTIDDTEMI DGVVLTQTAI KSAGGPTRKE KAKIGLIQFQ 240
  241 ISPPKPDTEN NIIVNDYRQM DKILKEERAY LLNICKKIKK AKCNVLLIQK SILRDAVNDL 300
  301 ALHFLSKLNI MVVKDIEREE IEFLSKGLGC KPIADIELFT EDRLGSADLV EEIDSDGSKI 360
  361 VRVTGIRNNN ARPTVSVVIR GANNMIIDET ERSLHDALCV IRCLVKERGL IAGGGAPEIE 420
  421 ISRRLSKEAR SMEGVQAFIW QEFASALEVI PTTLAENAGL NSIKVVTELR SKHENGELND 480
  481 GISVRRSGTT NTYEEHILQP VLVSTSAITL ASECVKSILR IDDIAFSR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CCT4 CCT6
    View Details (MIPS) Mewes HW, et al. (2004) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 TCP1
    View Details Krogan NJ, et al. (2006) CCT2 CCT4 CCT6
    View Details Gavin AC, et al. (2002) ADH1 CCT4 CHC1 COG8 CSE1 DHH1 DUG1 ECM29 FKS1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN1 GCN20 GCN3 GFA1 GUT1 IDH2 IST1 KAP123 KTR3 MIR1 PDC1 PRO1 RGR1 RRP40 RRP46 SAM1 SEC7 SLC1 SRV2 SUI2 SUI3 XKS1 YHR020W
    View Details Qiu et al. (2008) CCT2 CCT3 CCT4 CCT5 CCT6 CCT7 CCT8 SSA2 TCP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen FLO5 CCT4 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..105]
    [139..412]
    [495..528]    		 PSI-BLAST 1018.9691 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
    2 View Details [106..138]
    [413..494]    		 PSI-BLAST 1018.9691 Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  9.9038451294995 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  3.11215702001989 bayes_pls_golite062009
  • protein binding
    		•  2.03574683256805 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.88769858570433 bayes_pls_golite062009
  • ATPase activity
    		•  1.85640607183492 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.81343301131567 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.79412354283105 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.79183933227438 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • hydrolase activity
    		•  0.577900060851977 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.527748436977659 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • transferase activity
    		•  0.18639662517366 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.16424934648837 bayes_pls_golite062009
  • catalytic activity
    		•  0.107125378994589 bayes_pls_golite062009
  • kinase activity
    		•  0.0871496920547826 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle