YRC Public Data Repository - Protein Structure Prediction

Protein:	CCT4
Organism:	Saccharomyces cerevisiae
Length:	528 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCT4.

Description	E-value	Query Range	Subject Range
gi\|18978346, gi\|... - gi\|18978346\|ref\|NP_579703.1\| thermosome, single subunit [Pyrococcus furiosus DSM 3638], gi\|18894178\|...	0.0	[3..527]	[7..524]
THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=ths PE=3 SV=1 THS_PYRAB - Thermosome subunit OS=Pyrococcus abyssi GN=ths PE=3 SV=1	0.0	[3..527]	[7..524]
THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139... THS_PYRHO - Thermosome subunit OS=Pyrococcus horikoshii GN=ths PE=3 SV=1	0.0	[3..527]	[7..524]
THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain KS-1) GN=thsB PE=3 SV=2 THSB_THEK1 - Thermosome subunit beta OS=Thermococcus sp. (strain JCM 11816 / KS-1) GN=thsB PE=3 SV=2	0.0	[3..527]	[7..524]
THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus GN=thsB PE=3 SV=1 THSB_ARCFU - Thermosome subunit beta OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 /...	0.0	[3..528]	[7..525]
THSB_PYRKO - Thermosome subunit beta OS=Pyrococcus kodakaraensis GN=thsB PE=3 SV=1 THSB_THEKO - Thermosome subunit beta OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=ths... gi\|473965, gi\|21... - gi\|473965\|dbj\|BAA06143.1\| heat-shock protein [Pyrococcus sp.], pir\|\|S61294 heat-shock protein - Pyro...	0.0	[3..527]	[7..524]
THS_METKA - Thermosome subunit OS=Methanopyrus kandleri GN=ths PE=3 SV=1 THS_METKA - Thermosome subunit OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=ths...	0.0	[4..528]	[10..527]
gi\|2129425 - gi\|2129425\|pir\|\|JC4270 hyperthermophilic heat shock protein - Desulfurococcus mobilis gi\|1168091 - gi\|1168091\|gb\|AAB35235.1\| hyperthermophilic heat shock protein; HHSP [Desulfurococcus] THS_DESSY - Thermosome subunit OS=Desulfurococcus sp. (strain SY) GN=ths PE=3 SV=1	0.0	[3..527]	[7..524]
THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix GN=thsB PE=3 SV=2 THSB_AERPE - Thermosome subunit beta OS=Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138...	0.0	[4..527]	[15..532]

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Predicted Domain #1

Region A:
Residues: [1-105]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKVPSNAT FKNKEKPQEV RKANIIAARS VADAIRTSLG PKGMDKMIKT SRGEIIISND  60
   61 GHTILKQMAI LHPVARMLVE VSAAQDSEAG DGTTSVVILT GALLG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [139-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CHKVSLSDRE QLVRAASTSL SSKIVSQYSS FLAPLAVDSV LKISDENSKN VDLNDIRLVK  60
   61 KVGGTIDDTE MIDGVVLTQT AIKSAGGPTR KEKAKIGLIQ FQISPPKPDT ENNIIVNDYR 120
  121 QMDKILKEER AYLLNICKKI KKAKCNVLLI QKSILRDAVN DLALHFLSKL NIMVVKDIER 180
  181 EEIEFLSKGL GCKPIADIEL FTEDRLGSAD LVEEIDSDGS KIVRVTGIRN NNARPTVSVV 240
  241 IRGANNMIID ETERSLHDAL CVIRCLVKER GLIA

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [495-528]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EHILQPVLVS TSAITLASEC VKSILRIDDI AFSR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1018.9691
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
unfolded protein binding	9.9038451294995	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.6934849790316	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	3.40373598585301	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	3.28982639907979	bayes_pls_golite062009
binding	3.11215702001989	bayes_pls_golite062009
protein binding	2.03574683256805	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.88769858570433	bayes_pls_golite062009
ATPase activity	1.85640607183492	bayes_pls_golite062009
pyrophosphatase activity	1.81343301131567	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.79412354283105	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.79183933227438	bayes_pls_golite062009
nucleic acid binding	1.67284737458957	bayes_pls_golite062009
DNA binding	1.60256620441721	bayes_pls_golite062009
transporter activity	1.27879339110564	bayes_pls_golite062009
transmembrane transporter activity	1.08697283907212	bayes_pls_golite062009
chaperone binding	0.91200031047441	bayes_pls_golite062009
substrate-specific transporter activity	0.828920415160435	bayes_pls_golite062009
hydrolase activity	0.577900060851977	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.573106450426516	bayes_pls_golite062009
ATPase activity, coupled	0.527748436977659	bayes_pls_golite062009
ion transmembrane transporter activity	0.280310103153739	bayes_pls_golite062009
active transmembrane transporter activity	0.275534581026027	bayes_pls_golite062009
hydrogen-exporting ATPase activity, phosphorylative mechanism	0.26275673855778	bayes_pls_golite062009
primary active transmembrane transporter activity	0.252704226951294	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	0.243984617084631	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	0.205808843369749	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	0.202279803135899	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	0.20198255686005	bayes_pls_golite062009
transferase activity	0.18639662517366	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.16424934648837	bayes_pls_golite062009
catalytic activity	0.107125378994589	bayes_pls_golite062009
kinase activity	0.0871496920547826	bayes_pls_golite062009
cation transmembrane transporter activity	0.0778814959589007	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [106-138]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAERLLNKGI HPTIIADSFQ SAAKRSVDIL LEM

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [413-494]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGAPEIEIS RRLSKEARSM EGVQAFIWQE FASALEVIPT TLAENAGLNS IKVVTELRSK  60
   61 HENGELNDGI SVRRSGTTNT YE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1018.9691
Match:	1a6dA_
Description:	Thermosome, E domain; Thermosome, A-domain; Thermosome, I domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: