Protein Overview: CDC7

General Information:
Name(s) found:	CDC7 / YDL017W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|A25228 protein kinase CDC7 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|683680\|emb\|CAA88342.1\| protein kinase CDC7 (M12624) [Saccharomyces cerevisiae] [NCBI NR] gi\|6320187\|ref\|NP_010267.1\| DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expres [NCBI NR] gi\|171202\|gb\|AAA34485.1\| cdc7 gene product [NCBI NR] gi\|1430983\|emb\|CAA98574.1\| CDC7 [Saccharomyces cerevisiae] [NCBI NR] gi\|1168818\|sp\|P06243.2\|CDC7_YEAST RecName: Full=Cell division control protein 7 [NCBI NR] Cell division control protein 7 OS=Saccharomyces cerevisiae GN=CDC7 PE=1 SV=2 [Swiss-Prot] CDC7 Protein kinase [mips] DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression [SGD] CDC7, Chr IV from 424205-425728 [yeast_orfs2] Chr IV from 424205-425728 [yeastorf3.fasta] (P06243) Cell division control protein 7 (EC 2.7.1.37) [4932.FASTACCERV.txt] CDC7 SGDID:S0002175, Chr IV from 424206-425729, Verified ORF [yeastflysequest.fasta] Cdc7p [Saccharomyces cerevisiae]gi\|1430983\|emb\|CAA98574.1\| CDC7 [Saccharomyces cerevisiae]gi\|683680\|emb\|CAA88342.1\| protein kinase CDC7 (M12624) [Saccharomyces cerevisiae]gi\|1168818\|sp\|P06243\|CDC7_YEAST Cell division control protein 7gi\|82943\|pir\|\|A25 [nrdb_11152004_Chlamydomonas] CDC7 SGDID:S000002175, Chr IV from 424206-425729, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CDC7 SGDID:S000002175, Chr IV from 424207-425730, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; Cdc7p [Saccharomyces c [nr-271106-contam.fasta] Cell division control protein 7 [nr-271106-contam.fasta] protein kinase CDC7 (M12624) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] cdc7 gene product [nr-271106-contam.fasta] CDC7 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CDC7 SGDID:S000002175, Chr IV from 424207-425730, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression" [yeast-bovrabprots.fasta] CDC7 SGDID:S000002175, Chr IV from 424206-425729, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression" [yeast-contam_custom.fasta] [chemostatdb.fasta] Cell division control protein 7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CDC7 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CDC7 SGDID:S000002175, Chr IV from 424209-425732, Genome Release 64-1-1, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression" [yeast-030211-contam.fasta] CDC7 SGDID:S000002175, Chr IV from 424209-425732, Genome Release 64-2-1, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of the monopolin complex to kinetochores during meiosis I and as a gene-specific regulator of the meiosis-specific transcription factor Ndt80p" [20141208_orf_trans.fasta] YDL017W SGDID:S000002175, Chr IV from 424209-425732, Genome Release 64-1-1, Verified ORF, "DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	507 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] Dbf4-dependent protein kinase complex [IGI]
Biological Process:	DNA replication initiation [IMP] protein amino acid phosphorylation [IMP ]
Molecular Function:	protein serine/threonine kinase activity [IMP ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKTKNIDD IPPEIKEEMI QLYHDLPGIE NEYKLIDKIG EGTFSSVYKA KDITGKITKK  60
   61 FASHFWNYGS NYVALKKIYV TSSPQRIYNE LNLLYIMTGS SRVAPLCDAK RVRDQVIAVL 120
  121 PYYPHEEFRT FYRDLPIKGI KKYIWELLRA LKFVHSKGII HRDIKPTNFL FNLELGRGVL 180
  181 VDFGLAEAQM DYKSMISSQN DYDNYANTNH DGGYSMRNHE QFCPCIMRNQ YSPNSHNQTP 240
  241 PMVTIQNGKV VHLNNVNGVD LTKGYPKNET RRIKRANRAG TRGFRAPEVL MKCGAQSTKI 300
  301 DIWSVGVILL SLLGRRFPMF QSLDDADSLL ELCTIFGWKE LRKCAALHGL GFEASGLIWD 360
  361 KPNGYSNGLK EFVYDLLNKE CTIGTFPEYS VAFETFGFLQ QELHDRMSIE PQLPDPKTNM 420
  421 DAVDAYELKK YQEEIWSDHY WCFQVLEQCF EMDPQKRSSA EDLLKTPFFN ELNENTYLLD 480
  481 GESTDEDDVV SSSEADLLDK DVLLISE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CDC7 DBF4 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6
View Details	Krogan NJ, et al. (2006)		ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
View Details	Ho Y, et al. (2002)		BFR2 BIR1 BNA5 CDC7 ECM10 JIP3 NUT1 PDC5 PDC6 PST2 RPC19 SAR1 SEC27 STI1 THI3 TPS1 UBI4 VAC14
View Details	Qiu et al. (2008)		CDC7 DBF4 ORC3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC53	CDC7	2	Uetz P, et al. (2000)
View Screen	GPI16	CDC7	1	Unpublished Fields Lab Data
View Screen	MET18	CDC7	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CDC7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..122]	PSI-BLAST	243.0	Cyclin-dependent PK, CDK2
2	View Details	[123..200]	PSI-BLAST	243.0	Cyclin-dependent PK, CDK2
3	View Details	[201..252]	PSI-BLAST	243.0	Cyclin-dependent PK, CDK2
4	View Details	[253..304]	PSI-BLAST	243.0	Cyclin-dependent PK, CDK2
5	View Details	[305..422]	MSA	1.322978	View MSA. No confident structure predictions are available.
6	View Details	[423..507]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
acetylcholine receptor activator activity	3.57683141337465	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
tau-protein kinase activity	2.37138140221719	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.94085498993561	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
molecular transducer activity	1.79921740914853	bayes_pls_golite062009
signal transducer activity	1.79921740914853	bayes_pls_golite062009
small conjugating protein ligase activity	1.74206248731815	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	1.70788499622067	bayes_pls_golite062009
transmembrane receptor protein kinase activity	1.68012041942855	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.38496328649031	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
receptor signaling protein activity	1.27291233344322	bayes_pls_golite062009
acid-amino acid ligase activity	1.2266791546014	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
insulin receptor substrate binding	0.98689034826741	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.938271345744087	bayes_pls_golite062009
transmembrane receptor activity	0.913893847407112	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
receptor activity	0.775180603313375	bayes_pls_golite062009
transporter activity	0.595111702412257	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
kinase binding	0.443916188551908	bayes_pls_golite062009
transmembrane transporter activity	0.41384976209545	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
axon guidance receptor activity	0.330635248803668	bayes_pls_golite062009
protein kinase binding	0.285611963740145	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.19622756073807	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.19622756073807	bayes_pls_golite062009
growth factor binding	0.153144089598532	bayes_pls_golite062009
substrate-specific transporter activity	0.0922946791401962	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2