Protein Overview: THR4

General Information:
Name(s) found:	THR4 / YCR053W [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|SYBSR threonine synthase (EC 4.2.3.1) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|6319901\|ref\|NP_009982.1\| Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; Thr4p [Saccharomyces cerevisiae] [NCBI NR] gi\|4616\|emb\|CAA35157.1\| threonine synthase [Saccharomyces cerevisiae] [NCBI NR] gi\|1907196\|emb\|CAA42284.1\| threonine synthase (o-p-homoserine p-lyase) [Saccharomyces cerevisiae] [NCBI NR] gi\|135816\|sp\|P16120.1\|THRC_YEAST RecName: Full=Threonine synthase; Short=TS [NCBI NR] Threonine synthase OS=Saccharomyces cerevisiae GN=THR4 PE=1 SV=1 [Swiss-Prot] THR4 Threonine synthase (o-p-homoserine p-lyase) [mips] Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway [SGD] THR4, Chr III from 216689-218233 [yeast_orfs2] Chr III from 216689-218233 [yeastorf3.fasta] (P16120) Threonine synthase (EC 4.2.3.1) (TS) [4932.FASTACCERV.txt] THR4 SGDID:S0000649, Chr III from 216692-218236, Verified ORF [yeastflysequest.fasta] Thr4p [Saccharomyces cerevisiae]gi\|1907196\|emb\|CAA42284.1\| threonine synthase (o-p-homoserine p-lyase) [Saccharomyces cerevisiae]gi\|4616\|emb\|CAA35157.1\| threonine synthase [Saccharomyces cerevisiae]gi\|68353\|pir\|\|SYBSR threonine synthase (EC 4.2.3.1) - [nrdb_11152004_Chlamydomonas] THR4 SGDID:S000000649, Chr III from 216692-218236, Verified ORF, "Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] THR4 SGDID:S000000649, Chr III from 216693-218237, Verified ORF, "Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" [yeast-contam.fasta] Threonine synthase (TS) [nr-271106-contam.fasta] Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway; Thr4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] threonine synthase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] threonine synthase (o-p-homoserine p-lyase) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Threonine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THR4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] THR4 SGDID:S000000649, Chr III from 216697-218241, Genome Release 64-1-1, Verified ORF, "Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" [yeast-030211-contam.fasta] THR4 SGDID:S000000649, Chr III from 216697-218241, Genome Release 64-2-1, Verified ORF, "Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" [20141208_orf_trans.fasta] TR8912\|c0_g1_i1\|g.6192 ORF TR8912\|c0_g1_i1\|g.6192 TR8912\|c0_g1_i1\|m.6192 type:complete len:515 (+) TR8912\|c0_g1_i1:2640-4184(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR6160\|c0_g1_i1\|g.4376 ORF TR6160\|c0_g1_i1\|g.4376 TR6160\|c0_g1_i1\|m.4376 type:complete len:515 (+) TR6160\|c0_g1_i1:2645-4189(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YCR053W SGDID:S000000649, Chr III from 216697-218241, Genome Release 64-1-1, Verified ORF, "Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_9174\|g.6670 ORF asmbl_9174\|g.6670 asmbl_9174\|m.6670 type:complete len:515 (+) asmbl_9174:2637-4181(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_9211\|g.6589 ORF asmbl_9211\|g.6589 asmbl_9211\|m.6589 type:complete len:515 (+) asmbl_9211:2646-4190(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_9275\|g.5674 ORF ID=asmbl_9275\|g.5674 ID=asmbl_9275\|m.5674 type:complete len:515 (+) ID=asmbl_9275:2637-4181(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_9219\|g.5546 ORF ID=asmbl_9219\|g.5546 ID=asmbl_9219\|m.5546 type:complete len:515 (+) ID=asmbl_9219:2650-4194(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	514 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	endocytosis [IMP] threonine metabolic process [TAS]
Molecular Function:	threonine synthase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNASQVYRS TRSSSPKTIS FEEAIIQGLA TDGGLFIPPT IPQVDQATLF NDWSKLSFQD  60
   61 LAFAIMRLYI AQEEIPDADL KDLIKRSYST FRSDEVTPLV QNVTGDKENL HILELFHGPT 120
  121 YAFKDVALQF VGNLFEYFLQ RTNANLPEGE KKQITVVGAT SGDTGSAAIY GLRGKKDVSV 180
  181 FILYPTGRIS PIQEEQMTTV PDENVQTLSV TGTFDNCQDI VKAIFGDKEF NSKHNVGAVN 240
  241 SINWARILAQ MTYYFYSFFQ ATNGKDSKKV KFVVPSGNFG DILAGYFAKK MGLPIEKLAI 300
  301 ATNENDILDR FLKSGLYERS DKVAATLSPA MDILISSNFE RLLWYLAREY LANGDDLKAG 360
  361 EIVNNWFQEL KTNGKFQVDK SIIEGASKDF TSERVSNEET SETIKKIYES SVNPKHYILD 420
  421 PHTAVGVCAT ERLIAKDNDK SIQYISLSTA HPAKFADAVN NALSGFSNYS FEKDVLPEEL 480
  481 KKLSTLKKKL KFIERADVEL VKNAIEEELA KMKL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ERG13 THR4
View Details	Ho Y, et al. (2002)		AAT2 ACS2 ADE3 ADE6 ADH4 ADO1 ALA1 APE2 ARA1 ARG4 BAT1 CAR2 CDC10 CDC11 CDC12 CDC3 CDC60 CLU1 CPR1 CYS3 DED81 DPS1 ENP1 ERG10 ERG20 GCY1 GPH1 GRS1 HOM2 HYP2 ILS1 IMD3 KRS1 LSP1 MDH3 MPC54 NAS6 OLA1 PAB1 PDC5 PFK2 PGM2 PMI40 PRP6 SAC6 SCP160 SHS1 SOD1 SSZ1 SUI1 SUI2 SUI3 THR4 TPS1 TRR1 UBA1 YDL124W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#25 Asynchronous Prep3-TiO2 Flowthrough	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	THR4	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..97] [116..143] [240..255] [478..482]	PSI-BLAST	10125.0	Threonine synthase
2	View Details	[98..115] [144..239] [256..477] [483..514]	PSI-BLAST	10125.0	Threonine synthase

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: THR4

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: