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View Structure Prediction Details

Protein: THR4
Organism: Saccharomyces cerevisiae
Length: 514 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THR4.

Description E-value Query
Range		 Subject
Range
THR4 - Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine...
gi|190406480 - gi|190406480|gb|EDV09747.1| threonine synthase [Saccharomyces cerevisiae RM11-1a]
THRC_YEAST - Threonine synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THR4 PE=1 SV=1
gi|151943871 - gi|151943871|gb|EDN62171.1| threonine synthase [Saccharomyces cerevisiae YJM789]
 0.0 [1..514] [1..514]
THRC_ASHGO - Threonine synthase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=...
THRC_ASHGO - Threonine synthase OS=Ashbya gossypii GN=THR4 PE=3 SV=1
 0.0 [5..512] [2..507]
gi|629563 - gi|629563|pir||S49036 threonine synthase (EC 4.2.3.1) - Arabidopsis thaliana
SPAC9E9.06c - threonine synthase
THRC_SCHPO - Threonine synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=thrc PE=1 SV=1
 0.0 [4..513] [2..513]
gi|85081402 - gi|85081402|ref|XP_956711.1| threonine synthase [Neurospora crassa OR74A]
gi|28917786, gi|... - gi|32404140|ref|XP_322683.1| hypothetical protein [Neurospora crassa], gi|28917786|gb|EAA27475.1| th...
 0.0 [6..512] [21..550]
THRC_PSEAE - Threonine synthase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) G...
THRC_PSEAE - Threonine synthase OS=Pseudomonas aeruginosa GN=thrC PE=3 SV=3
 0.0 [7..508] [2..462]
gi|15077836 - gi|15077836|gb|AAK83373.1| threonine synthase Thr4 [Filobasidiella neoformans]
 1.0E-99 [7..512] [6..541]
gi|17739159, gi|... - gi|17934697|ref|NP_531487.1| threonine synthase [Agrobacterium tumefaciens str. C58], gi|17739159|gb...
gi|25292062, gi|... - pir||AE2673 threonine synthase [imported] - Agrobacterium tumefaciens (strain C58, Dupont), pir||C...
 4.0E-98 [8..508] [61..518]
gi|254729809 - gi|254729809|ref|ZP_05188387.1| threonine synthase [Brucella abortus bv. 4 str. 292]
gi|189023714, gi... - gi|189023714|ref|YP_001934482.1| threonine synthase [Brucella abortus S19], gi|189019286|gb|ACD72008...
gi|82699391 - gi|82699391|ref|YP_413965.1| threonine synthase [Brucella melitensis biovar Abortus 2308]
gi|62289465, gi|... - gi|62289465|ref|YP_221258.1| threonine synthase [Brucella abortus bv. 1 str. 9-941], gi|62195597|gb|...
gi|82615492 - gi|82615492|emb|CAJ10466.1| Serine/threonine dehydratase, pyridoxal-phosphate attachment site:Pyrido...
gi|237814952, gi... - gi|237814952|ref|ZP_04593950.1| threonine synthase [Brucella abortus str. 2308 A], gi|237789789|gb|E...
gi|225852020, gi... - gi|225852020|ref|YP_002732253.1| threonine synthase [Brucella melitensis ATCC 23457], gi|225640385|g...
gi|25292067 - pir||AD3433 threonine synthase (EC 4.2.3.1) [imported] - Brucella melitensis (strain 16M)
gi|254696906 - gi|254696906|ref|ZP_05158734.1| threonine synthase [Brucella abortus bv. 2 str. 86/8/59]
gi|17987733, gi|... - gi|17987733|ref|NP_540367.1| threonine synthase [Brucella melitensis 16M], gi|17983453|gb|AAL52631.1...
gi|254693260 - gi|254693260|ref|ZP_05155088.1| threonine synthase [Brucella abortus bv. 3 str. Tulya]
 5.0E-96 [8..508] [3..460]
gi|15073852 - gi|15073852|emb|CAC45493.1| Probable threonine synthase [Sinorhizobium meliloti 1021]
gi|15964674 - gi|15964674|ref|NP_385027.1| threonine synthase [Sinorhizobium meliloti 1021]
 8.0E-96 [8..507] [4..460]
gi|13476245, gi|... - gi|14027006|dbj|BAB53960.1| threonine synthase [Mesorhizobium loti MAFF303099], gi|13476245|ref|NP_1...
 9.0E-95 [8..505] [3..457]

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Predicted Domain #1
Region A:
Residues: [1-97] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNASQVYRS TRSSSPKTIS FEEAIIQGLA TDGGLFIPPT IPQVDQATLF NDWSKLSFQD  60
   61 LAFAIMRLYI AQEEIPDADL KDLIKRSYST FRSDEVT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [116-143] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FHGPTYAFKD VALQFVGNLF EYFLQRTN

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [240-255] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSINWARILA QMTYYF

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [478-482] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELKK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10125.0
Match: 1kl7A_
Description: Threonine synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
threonine synthase activity 3.59927532963055 bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates 2.61572425646119 bayes_pls_golite062009
catalytic activity 2.38994231321972 bayes_pls_golite062009
lyase activity 1.87743897464083 bayes_pls_golite062009
cysteine synthase activity 1.31641967296632 bayes_pls_golite062009
binding 1.19751827446411 bayes_pls_golite062009
tryptophan synthase activity 1.04832999357666 bayes_pls_golite062009
carbon-oxygen lyase activity 0.923824749425553 bayes_pls_golite062009
ammonia-lyase activity 0.476674617721478 bayes_pls_golite062009
L-threonine ammonia-lyase activity 0.37325071016009 bayes_pls_golite062009
protein binding 0.251404253093929 bayes_pls_golite062009
carbon-nitrogen lyase activity 0.249761226675912 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [98-115] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLVQNVTGDK ENLHILEL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [144-239] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANLPEGEKKQ ITVVGATSGD TGSAAIYGLR GKKDVSVFIL YPTGRISPIQ EEQMTTVPDE  60
   61 NVQTLSVTGT FDNCQDIVKA IFGDKEFNSK HNVGAV

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [256-477] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSFFQATNGK DSKKVKFVVP SGNFGDILAG YFAKKMGLPI EKLAIATNEN DILDRFLKSG  60
   61 LYERSDKVAA TLSPAMDILI SSNFERLLWY LAREYLANGD DLKAGEIVNN WFQELKTNGK 120
  121 FQVDKSIIEG ASKDFTSERV SNEETSETIK KIYESSVNPK HYILDPHTAV GVCATERLIA 180
  181 KDNDKSIQYI SLSTAHPAKF ADAVNNALSG FSNYSFEKDV LP

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [483-514] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSTLKKKLKF IERADVELVK NAIEEELAKM KL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10125.0
Match: 1kl7A_
Description: Threonine synthase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle