Protein Overview: ARC40

General Information:
Name(s) found:	ARC40 / YBR234C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6319711\|ref\|NP_009793.1\| Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc40p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46110 hypothetical protein YBR234c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|586351\|sp\|P38328.1\|ARPC1_YEAST RecName: Full=Actin-related protein 2/3 complex subunit 1; AltName: Full=Arp2/3 complex 41 kDa subunit; AltName: Full=p41-ARC [NCBI NR] gi\|536635\|emb\|CAA85197.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|51012967\|gb\|AAT92777.1\| YBR234C [Saccharomyces cerevisiae] [NCBI NR] Actin-related protein 2/3 complex subunit 1 OS=Saccharomyces cerevisiae GN=ARC40 PE=1 SV=1 [Swiss-Prot] (P38328) Probable ARP2/3 complex 41 kDa subunit (P41-ARC) [Swiss-Prot] ARC40 Arp2/3 protein complex subunit, 40 kilodalton [mips] Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [SGD] ARC40, Chr II from 685396-686550, reverse complement [yeast_orfs2] Chr II from 685396-686550, reverse complement [yeastorf3.fasta] Chr II from 685395-686549, reverse complement [yeastorf4.fasta] Chr II from 686547-685393, reverse complement [yeastorf5.fasta] ARC40 SGDID:S0000438, Chr II from 686549-685395, reverse complement, Verified ORF [yeastflysequest.fasta] ARC40 SGDID:S0000438, Chr II from 686587-685433, reverse complement, Verified ORF [10112005cervSGD.fasta] Arc40p [Saccharomyces cerevisiae]gi\|51012967\|gb\|AAT92777.1\| YBR234C [Saccharomyces cerevisiae]gi\|536635\|emb\|CAA85197.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|626550\|pir\|\|S46110 hypothetical protein YBR234c - yeast (Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas] ARC40 SGDID:S000000438, Chr II from 686587-685433, reverse complement, Verified ORF, "Essential subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ARC40 SGDID:S000000438, Chr II from 686587-685433, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YBR234C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Probable ARP2/3 complex 41 kDa subunit (p41-ARC) [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Essential subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; Arc40p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Actin-related protein 2/3 complex subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARC40 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ARC40 SGDID:S000000438, Chr II from 686592-685438, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" [yeast-030211-contam.fasta] ARC40 SGDID:S000000438, Chr II from 686592-685438, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" [20141208_orf_trans.fasta] YBR234C SGDID:S000000438, Chr II from 686592-685438, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	384 amino acids
Gene Ontology:
Cellular Component:	Arp2/3 protein complex [IDA ]
Biological Process:	mitochondrion inheritance [TAS] actin nucleation [IDA] actin filament organization [IMP]
Molecular Function:	structural constituent of cytoskeleton [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSNSKDKS VVAVYKLVKA PIYSHCFSQD KSILAVTCET DCLVYRVSNN TPPVLFATLK  60
   61 DHDKTITAVD ISIHGRIVTC SQDRNAYVWE PLSDGTYKPT LVLLRINRAA TSVTWAPNGY 120
  121 KFAVGSSARI IAVCYYEHEN NWWVSKHIKK PIKSTINCLS WHANGVLLAA GGTDGFMRVF 180
  181 SGFIKGLDSK ESVAGSPWGQ KFPFGCLIRE WYQGSYIHDV EWRSQMERIA YVAHDGTLNV 240
  241 VDYQSPVQSV NAPEGLPYRS LVWINDHEIV CGGYSCHPVL FSEASEGWKF AKNLDKSDNN 300
  301 KSSALTASGN TDELSGNNDE SSTFGISALR KFKELDLKGK VSTDVQESAH ENAIVELRPF 360
  361 AESNGQITQV SSCGLDGKIV IYTI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
View Details	(MIPS) Mewes HW, et al. (2004)		ABP1 AIP1 ARC40 ARP2 BEM1 BUD6 CAP1 CAP2 COF1 CRN1 DLD2 GLK1 LAS17 OYE2 PAN1 PFY1 RVS167 SAC6 SLA1 SLA2 SRV2 TPM1 TPM2 TWF1 VRP1
View Details	Krogan NJ, et al. (2006)		ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 PAC1 TAP42
View Details	Gavin AC, et al. (2006)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3
View Details	Gavin AC, et al. (2002)		ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 CCT5 CCT8 NOG2 PFK1 PRT1
View Details	Ho Y, et al. (2002)		ADR1 ARC15 ARC18 ARC19 ARC35 ARC40 ARP2 ARP3 ATP3 BNI1 DUR1,2 FET3 GFA1 IMH1 KAP122 MCM4 MCM7 MET18 NIP1 NOP4 POB3 PST2 PUF3 RPN8 RPT4 RVB1 SSZ1 TRP3 YJR029W YLR241W YNL040W
View Details	Qiu et al. (2008)		ABP1 ACT1 AIP1 ARC40 ARP2 BNI1 CAP1 CAP2 COF1 CRN1 JNM1 LAS17 MHP1 MYO5 PFY1 RVS161 RVS167 SAC6 SLA1 SRV2 TPM1 TPM2 VRP1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RAD51	ARC40	1	Unpublished Fields Lab Data
View Screen	AGA2	ARC40	1	Unpublished Fields Lab Data
View Screen	SWI5	ARC40	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ARC40	Huh WK, et al. (2003)
View Data	ARC40 and SAC6	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..384]	PSI-BLAST	659.30103	Arp2/3 complex 41 kDa subunit ARPC1

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
actin binding	3.86142918698875	bayes_pls_golite062009
cytoskeletal protein binding	3.1056443224755	bayes_pls_golite062009
actin filament binding	2.0735069176589	bayes_pls_golite062009
binding	1.79788997337153	bayes_pls_golite062009
dynein binding	1.69349714290074	bayes_pls_golite062009
protein binding	1.11897341394404	bayes_pls_golite062009
myosin binding	0.989691178611801	bayes_pls_golite062009
tubulin binding	0.968047176592527	bayes_pls_golite062009
microtubule binding	0.834073483714259	bayes_pls_golite062009
transporter activity	0.692270256454453	bayes_pls_golite062009
	0.45054027253231	bayes_pls_golite062009
myosin II binding	0.33142771724387	bayes_pls_golite062009
myosin heavy chain kinase activity	0.231534552000461	bayes_pls_golite062009
substrate-specific transporter activity	0.121183207943714	bayes_pls_golite062009
structural constituent of cytoskeleton	0.118975415284669	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.00585398682921312	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2