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Protein Overview: SSE2

General Information:
Name(s) found: SSE2 / YBR169C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 693 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: protein folding [ISSLink to PubMed article]
    protein refolding [IGILink to PubMed article]
    Molecular Function: adenyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPFGLDLG NNNSVLAVAR NRGIDVVVNE VSNRSTPSLV GFGPRNRYLG ESGKTKQTSN  60
   61 VKNTVENLKR IIGLKFKDPE FDIENKFFTS KLVQLKNGKV GVEVEFGGKT HVFSATQLTA 120
  121 MFIDKVKHTV QEETKSSITD VCLAVPVWYS EEQRYNIADA ARIAGLNPVR IVNDVTAAAV 180
  181 SYGVFKNDLP GPEEKPRIIG LVDIGHSTYT CSIMAFRKGE MKVLGTAYDK HFGGRDFDRA 240
  241 ITEHFADQFK DKYKIDIRKN PKAYNRILIA AEKLKKVLSA NTTAPFSVES VMDDIDVSSQ 300
  301 LSREELEELV EPLLKRVTYP ITNALAQAKL TVNDIDFVEI IGGTTRIPVL KKSISDVFGK 360
  361 PLSSTLNQDE AVAKGAAFIC AIHSPTLRVR PFKFEDIDPY SVSYTWDKQV DDEDRLEVFP 420
  421 ANSSYPSTKL ITLHRTGDFS MKAVYTHPSK LPKGTSTTIA KWSFTGVKVP KDQDFIPVKV 480
  481 KLRCDPSGLH IIENAYTTED ITVQEPVPLP EDAPEDAEPQ FKEVTKTIKK DVLGMTAKTF 540
  541 ALNPVELNDL IEKENELRNQ DKLVAETEDR KNALEEYIYT LRAKLDDEYS DFASDAEKEK 600
  601 LKNMLATTEN WLYGDGDDST KAKYIAKYEE LASLGNIIRG RYLAKEEEKR QALRANQETS 660
  661 KMNDIAEKLA EQRRARAASD DSDDNNDENM DLD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KEL2 SEN1 SSB2 SSE2 YPS7 ZUO1
    View Details Krogan NJ, et al. (2006) ACO1 BAT2 HSP42 NTH2 RRP12 SRS2 SSE2
    View Details Gavin AC, et al. (2006) GET4 SSE2
    View Details Gavin AC, et al. (2002) ADA2 ADH1 COG3 CSE2 CTK1 CTK2 CTK3 ENO2 FAB1 FAR11 FAR3 FBA1 GAL11 GCN5 GPM1 HFM1 HSC82 MED1 MED11 MED2 MED4 MED6 MED7 MED8 MLP1 MRPL6 NUT1 NUT2 PDC1 PGD1 PGK1 RGR1 ROM2 ROX3 RPG1 RPO21 SIN4 SNT2 SPT7 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8 SRP1 SSE2 SSN2 SSN3 SSN8 TAF6 TIF1, TIF2 TPI1 YIL077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR1 No Comments Reinke A, et al. (2004)
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run NSE5 No Comments Hazbun TR, et al. (2003)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SSE2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174]
    [369..385]    		 PSI-BLAST 1625.228787 Heat shock protein 70kDa, ATPase fragment
    2 View Details [175..235]
    [311..368]    		 PSI-BLAST 1625.228787 Heat shock protein 70kDa, ATPase fragment
    3 View Details [236..310] PSI-BLAST 1625.228787 Heat shock protein 70kDa, ATPase fragment
    4 View Details [386..566] PSI-BLAST 77.69897 DnaK
    5 View Details [567..693] PSI-BLAST 77.69897 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  4.93074236328581 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • structural molecule activity
    		•  2.37892721989886 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • hydrolase activity
    		•  0.807017237368431 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.53527958884988 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • chromatin binding
    		•  0.155140608043269 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle