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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CCL1
  • mitochondrion
  • holo TFIIH complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
  • cyclin-dependent protein kinase regulator activity
  • general RNA polymerase II transcription factor activity
  • ESP1
  • nucleus
  • cytoplasm
  • mitochondrion
  • spindle
  • regulation of exit from mitosis
  • mitotic sister chromatid segregation
  • cysteine-type endopeptidase activity
  • KIN28
  • holo TFIIH complex
  • protein amino acid phosphorylation
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
  • cyclin-dependent protein kinase activating kinase activity
  • RNA polymerase II carboxy-terminal domain kinase activity
  • general RNA polymerase II transcription factor activity
  • cyclin-dependent protein kinase activity
  • RAD3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • DNA helicase activity
  • general RNA polymerase II transcription factor activity
  • SSL1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TFB4
  • holo TFIIH complex
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    holo TFIIH complex 1.2429E-20 8 10 7 6292
    DNA-directed RNA polymerase II, holoenzyme 2.3868E-14 8 56 7 6292
    transcription factor complex 1.3658E-13 8 71 7 6292
    nucleotide-excision repair factor 3 complex 3.7495E-11 8 7 4 6292
    nucleoplasm part 9.6603E-10 8 245 7 6292
    nucleoplasm 1.6353E-9 8 264 7 6292
    nucleotide-excision repair complex 6.3661E-9 8 21 4 6292
    nuclear lumen 7.205E-8 8 453 7 6292
    organelle lumen 9.8757E-7 8 660 7 6292
    intracellular organelle lumen 9.8757E-7 8 660 7 6292
    membrane-enclosed lumen 1.4845E-6 8 700 7 6292
    nuclear part 3.3951E-5 8 1103 7 6292
    protein complex 4.178E-5 8 1137 7 6292
    nucleus 1.2145E-4 8 2041 8 6292
    organelle part 2.9704E-4 8 2282 8 6292
    intracellular organelle part 2.9704E-4 8 2282 8 6292
    macromolecular complex 4.9027E-4 8 1635 7 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    negative regulation of transcription from RNA polymerase II promoter, mitotic 9.1141E-18 8 8 6 6292
    regulation of transcription from RNA polymerase II promoter, mitotic 9.1141E-18 8 8 6 6292
    regulation of transcription, mitotic 2.7335E-17 8 9 6 6292
    negative regulation of transcription, mitotic 2.7335E-17 8 9 6 6292
    transcription initiation from RNA polymerase II promoter 6.4806E-15 8 47 7 6292
    transcription initiation 3.0935E-14 8 58 7 6292
    negative regulation of transcription from RNA polymerase II promoter 1.6066E-11 8 60 6 6292
    nucleotide-excision repair, DNA duplex unwinding 1.6077E-11 8 6 4 6292
    protein complex biogenesis 3.7724E-11 8 155 7 6292
    protein complex assembly 3.7724E-11 8 155 7 6292
    regulation of transcription from RNA polymerase II promoter 5.8157E-10 8 228 7 6292
    macromolecular complex assembly 2.5372E-9 8 281 7 6292
    DNA geometric change 5.1561E-9 8 20 4 6292
    DNA duplex unwinding 5.1561E-9 8 20 4 6292
    negative regulation of transcription, DNA-dependent 5.8994E-9 8 157 6 6292
    negative regulation of RNA metabolic process 6.1305E-9 8 158 6 6292
    negative regulation of transcription 7.6813E-9 8 164 6 6292
    negative regulation of gene expression 7.6813E-9 8 164 6 6292
    transcription from RNA polymerase II promoter 8.7223E-9 8 335 7 6292
    negative regulation of macromolecule biosynthetic process 1.1372E-8 8 175 6 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.348E-8 8 180 6 6292
    negative regulation of nitrogen compound metabolic process 1.348E-8 8 180 6 6292
    macromolecular complex subunit organization 1.3624E-8 8 357 7 6292
    regulation of transcription, DNA-dependent 1.3893E-8 8 358 7 6292
    regulation of RNA metabolic process 1.5311E-8 8 363 7 6292
    negative regulation of biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of cellular biosynthetic process 1.8092E-8 8 189 6 6292
    negative regulation of macromolecule metabolic process 1.9893E-8 8 192 6 6292
    regulation of transcription 2.2701E-8 8 384 7 6292
    cellular component assembly 2.3118E-8 8 385 7 6292
    negative regulation of cellular metabolic process 3.3152E-8 8 209 6 6292
    negative regulation of metabolic process 3.4118E-8 8 210 6 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.9072E-8 8 415 7 6292
    regulation of nitrogen compound metabolic process 3.9735E-8 8 416 7 6292
    regulation of cellular process 6.3621E-8 8 796 8 6292
    regulation of gene expression 6.3624E-8 8 445 7 6292
    regulation of macromolecule biosynthetic process 7.5447E-8 8 456 7 6292
    nucleotide-excision repair 7.7836E-8 8 38 4 6292
    regulation of biological process 8.3992E-8 8 824 8 6292
    regulation of cellular biosynthetic process 9.597E-8 8 472 7 6292
    negative regulation of cellular process 9.7156E-8 8 250 6 6292
    regulation of biosynthetic process 9.7397E-8 8 473 7 6292
    negative regulation of biological process 1.0435E-7 8 253 6 6292
    regulation of macromolecule metabolic process 1.2108E-7 8 488 7 6292
    transcription, DNA-dependent 1.4952E-7 8 503 7 6292
    RNA biosynthetic process 1.6019E-7 8 508 7 6292
    regulation of primary metabolic process 1.7384E-7 8 514 7 6292
    regulation of cellular metabolic process 2.3274E-7 8 536 7 6292
    regulation of metabolic process 2.6807E-7 8 547 7 6292
    transcription 2.8559E-7 8 552 7 6292
    DNA conformation change 4.4283E-7 8 58 4 6292
    cellular component biogenesis 1.3986E-6 8 694 7 6292
    biological regulation 1.8727E-6 8 1213 8 6292
    RNA metabolic process 1.2557E-5 8 954 7 6292
    cellular component organization 1.5761E-5 8 1582 8 6292
    DNA repair 5.3445E-5 8 192 4 6292
    cellular macromolecule biosynthetic process 5.6045E-5 8 1187 7 6292
    macromolecule biosynthetic process 5.6692E-5 8 1189 7 6292
    gene expression 9.518E-5 8 1283 7 6292
    response to DNA damage stimulus 1.1994E-4 8 236 4 6292
    nucleic acid metabolic process 1.8497E-4 8 1415 7 6292
    cellular response to stress 2.671E-4 8 290 4 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.6683E-4 8 1566 7 6292
    cellular biosynthetic process 3.6841E-4 8 1567 7 6292
    biosynthetic process 4.2747E-4 8 1602 7 6292
    cellular response to stimulus 7.4705E-4 8 379 4 6292
    cellular nitrogen compound metabolic process 8.3438E-4 8 1770 7 6292
    nitrogen compound metabolic process 9.0281E-4 8 1791 7 6292
    response to stress 2.0819E-3 8 497 4 6292
    DNA metabolic process 3.8176E-3 8 585 4 6292
    cellular macromolecule metabolic process 4.5244E-3 8 2285 7 6292
    macromolecule metabolic process 5.4192E-3 8 2349 7 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    general RNA polymerase II transcription factor activity 6.386E-14 8 64 7 6292
    RNA polymerase II transcription factor activity 1.0759E-11 8 130 7 6292
    transcription regulator activity 9.4796E-9 8 339 7 6292
    RNA polymerase II carboxy-terminal domain kinase activity 1.2715E-3 8 1 1 6292
    protein kinase regulator activity 1.4238E-3 8 46 2 6292
    kinase regulator activity 1.6147E-3 8 49 2 6292
    cyclin-dependent protein kinase activating kinase activity 2.5415E-3 8 2 1 6292
    cysteine-type endopeptidase activity 5.0773E-3 8 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle