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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CLG1
  • cyclin-dependent protein kinase holoenzyme complex
    		•
  • cell cycle
    		•
  • cyclin-dependent protein kinase regulator activity
    		•
    CUE1
  • mitochondrion
  • integral to endoplasmic reticulum membrane
    		•
  • establishment of protein localization
  • ER-associated protein catabolic process
    		•
  • protein binding
    		•
    GTR1
  • nucleus
  • late endosome membrane
  • cytoplasm
  • vacuolar membrane
    		•
  • transcription from RNA polymerase III promoter
  • phosphate transport
  • transcription from RNA polymerase I promoter
  • telomere maintenance
    		•
  • GTPase activity
    		•
    HAM1
  • nucleus
  • cytoplasm
    		•
  • DNA repair
  • deoxyribonucleoside triphosphate catabolic process
    		•
  • nucleoside-triphosphate diphosphatase activity
    		•
    HRT1
  • nucleus
  • nuclear ubiquitin ligase complex
  • cytoplasm
  • SCF ubiquitin ligase complex
  • Cul3-RING ubiquitin ligase complex
    		•
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination during ubiquitin-dependent protein catabolic process
    		•
  • ubiquitin-protein ligase activity
    		•
    LAP3
  • cytoplasm
  • mitochondrion
    		•
  • response to antibiotic
    		•
  • nucleic acid binding
  • transcription regulator activity
  • cysteine-type peptidase activity
    		•
    TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • protein metabolic process
  • vacuolar acidification
  • intron homing
    		•
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
    		•
    VMA10
  • vacuolar proton-transporting V-type ATPase, V1 domain
    		•
  • glycogen metabolic process
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA13
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA2
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • cytoplasm
    		•
  • vacuolar acidification
  • cellular calcium ion homeostasis
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA7
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
    		•
  • vacuolar acidification
    		•
  • proton-transporting ATPase activity, rotational mechanism
    		•
    XDJ1
  • nucleus
  • mitochondrion
    		•
  • telomere maintenance
    		•
  • chaperone regulator activity
    		•
    YIG1
  • nucleus
  • cytosol
    		•
  • glycerol biosynthetic process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    proton-transporting V-type ATPase, V1 domain 9.7589E-16 14 8 6 6292
    vacuolar proton-transporting V-type ATPase, V1 domain 9.7589E-16 14 8 6 6292
    proton-transporting two-sector ATPase complex, catalytic domain 5.9483E-14 14 13 6 6292
    proton-transporting V-type ATPase complex 1.7311E-13 14 15 6 6292
    vacuolar proton-transporting V-type ATPase complex 1.7311E-13 14 15 6 6292
    proton-transporting two-sector ATPase complex 5.4927E-11 14 35 6 6292
    vacuolar membrane 1.5472E-9 14 113 7 6292
    vacuolar part 2.5095E-9 14 121 7 6292
    vacuole 1.137E-7 14 209 7 6292
    fungal-type vacuole membrane 1.6145E-5 14 74 4 6292
    organelle membrane 3.3735E-5 14 692 8 6292
    membrane part 2.4454E-4 14 662 7 6292
    fungal-type vacuole 3.1481E-4 14 158 4 6292
    lytic vacuole 3.1481E-4 14 158 4 6292
    storage vacuole 3.1481E-4 14 158 4 6292
    protein complex 1.1859E-3 14 1137 8 6292
    membrane 1.6969E-3 14 1198 8 6292
    cytoplasmic part 3.4004E-3 14 2482 11 6292
    cytoplasm 3.9088E-3 14 3552 13 6292
    membrane-bounded organelle 7.9402E-3 14 3771 13 6292
    intracellular membrane-bounded organelle 7.9402E-3 14 3771 13 6292
    Cul3-RING ubiquitin ligase complex 8.8726E-3 14 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pH reduction 4.6098E-12 14 24 6 6292
    intracellular pH reduction 4.6098E-12 14 24 6 6292
    vacuolar acidification 4.6098E-12 14 24 6 6292
    regulation of cellular pH 6.0589E-12 14 25 6 6292
    regulation of intracellular pH 6.0589E-12 14 25 6 6292
    regulation of pH 1.618E-11 14 29 6 6292
    cellular monovalent inorganic cation homeostasis 4.5561E-11 14 34 6 6292
    monovalent inorganic cation homeostasis 9.3113E-11 14 38 6 6292
    cellular cation homeostasis 5.0425E-8 14 105 6 6292
    cation homeostasis 6.3169E-8 14 109 6 6292
    cellular chemical homeostasis 1.0706E-7 14 119 6 6292
    cellular ion homeostasis 1.0706E-7 14 119 6 6292
    cellular homeostasis 1.1257E-7 14 120 6 6292
    chemical homeostasis 1.3052E-7 14 123 6 6292
    ion homeostasis 1.3052E-7 14 123 6 6292
    homeostatic process 6.2078E-7 14 408 8 6292
    regulation of biological quality 6.1442E-6 14 551 8 6292
    biological regulation 1.847E-3 14 1213 8 6292
    deoxyribonucleoside triphosphate catabolic process 4.4455E-3 14 2 1 6292
    deoxyribonucleotide catabolic process 4.4455E-3 14 2 1 6292
    response to antibiotic 6.6614E-3 14 3 1 6292
    alditol biosynthetic process 8.8726E-3 14 4 1 6292
    deoxyribonucleoside triphosphate metabolic process 8.8726E-3 14 4 1 6292
    glycerol biosynthetic process 8.8726E-3 14 4 1 6292
    polyol biosynthetic process 8.8726E-3 14 4 1 6292
    proteasomal protein catabolic process 9.9063E-3 14 69 2 6292
    proteasomal ubiquitin-dependent protein catabolic process 9.9063E-3 14 69 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    proton-transporting ATPase activity, rotational mechanism 5.9483E-14 14 13 6 6292
    cation-transporting ATPase activity 2.7668E-13 14 16 6 6292
    ATPase activity, coupled to transmembrane movement of ions 1.618E-11 14 29 6 6292
    hydrogen ion transmembrane transporter activity 8.5596E-10 14 54 6 6292
    primary active transmembrane transporter activity 9.5972E-10 14 55 6 6292
    ATPase activity, coupled to transmembrane movement of substances 9.5972E-10 14 55 6 6292
    P-P-bond-hydrolysis-driven transmembrane transporter activity 9.5972E-10 14 55 6 6292
    hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 9.5972E-10 14 55 6 6292
    monovalent inorganic cation transmembrane transporter activity 1.4851E-9 14 59 6 6292
    ATPase activity, coupled to movement of substances 1.4851E-9 14 59 6 6292
    inorganic cation transmembrane transporter activity 3.9885E-8 14 101 6 6292
    cation transmembrane transporter activity 1.0177E-7 14 118 6 6292
    active transmembrane transporter activity 1.1831E-7 14 121 6 6292
    hydrolase activity, acting on acid anhydrides 2.0253E-7 14 353 8 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.0253E-7 14 353 8 6292
    pyrophosphatase activity 2.0253E-7 14 353 8 6292
    ion transmembrane transporter activity 3.6298E-7 14 146 6 6292
    ATPase activity, coupled 4.096E-7 14 149 6 6292
    nucleoside-triphosphatase activity 2.5048E-6 14 329 7 6292
    ATPase activity 3.1774E-6 14 211 6 6292
    substrate-specific transmembrane transporter activity 1.2438E-5 14 267 6 6292
    hydrolase activity 2.715E-5 14 911 9 6292
    transmembrane transporter activity 2.7168E-5 14 306 6 6292
    substrate-specific transporter activity 4.623E-5 14 336 6 6292
    transporter activity 1.3027E-4 14 404 6 6292
    catalytic activity 4.9147E-3 14 2150 10 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle