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Protein Overview: HAM1

General Information:
Name(s) found: HAM1 / YJR069C [SGD]
Description(s) found:
Found 37 descriptions.
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  • Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 197 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    deoxyribonucleoside triphosphate catabolic process [IDALink to PubMed article]
    Molecular Function: nucleoside-triphosphate diphosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNEIVFVT GNANKLKEVQ SILTQEVDNN NKTIHLINEA LDLEELQDTD LNAIALAKGK  60
   61 QAVAALGKGK PVFVEDTALR FDEFNGLPGA YIKWFLKSMG LEKIVKMLEP FENKNAEAVT 120
  121 TICFADSRGE YHFFQGITRG KIVPSRGPTT FGWDSIFEPF DSHGLTYAEM SKDAKNAISH 180
  181 RGKAFAQFKE YLYQNDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CLG1 CUE1 GTR1 HAM1 HRT1 LAP3 TFP1 VMA10 VMA13 VMA2 VMA7 VMA8 XDJ1 YIG1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HAM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77]
    [120..136]
    [182..197]    		 PSI-BLAST 262.39794 XTP pyrophosphatase
    2 View Details [78..119]
    [137..181]    		 PSI-BLAST 262.39794 XTP pyrophosphatase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleoside-triphosphate diphosphatase activity
    		•  2.4486133651528 bayes_pls_golite062009
  • binding
    		•  1.2828743465361 bayes_pls_golite062009
  • protein binding
    		•  0.121994365068808 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle