YRC Public Data Repository - Protein Structure Prediction

Protein:	HAM1
Organism:	Saccharomyces cerevisiae
Length:	197 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAM1.

Description	E-value	Query Range	Subject Range
gi\|151945137 - gi\|151945137\|gb\|EDN63388.1\| 6-n-hydroxylaminopurine sensitive [Saccharomyces cerevisiae YJM789] HAM1 - Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates excl... ITPA_YEAST - Inosine triphosphate pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAM... gi\|190409544 - gi\|190409544\|gb\|EDV12809.1\| protein HAM1 [Saccharomyces cerevisiae RM11-1a] gi\|207343836 - gi\|207343836\|gb\|EDZ71173.1\| YJR069Cp-like protein [Saccharomyces cerevisiae AWRI1631]	2.0E-66	[1..197]	[1..197]
gi\|12002044 - gi\|12002044\|gb\|AAG43165.1\|AF063607_1 brain my049 protein [Homo sapiens]	4.0E-63	[1..192]	[5..189]
ITPA_ARATH - Inosine triphosphate pyrophosphatase OS=Arabidopsis thaliana GN=At4g13720 PE=2 SV=1	1.0E-61	[4..194]	[14..194]
hap-1 - status:Confirmed UniProt:Q9GYG4 protein_id:AAG00041.1	1.0E-60	[1..195]	[1..184]
gi\|167468164 - gi\|167468164\|ref\|ZP_02332868.1\| non-canonical purine NTP pyrophosphatase RdgB [Yersinia pestis FV-1] gi\|167399887, gi... - gi\|167399887\|ref\|ZP_02305405.1\| non-canonical purine NTP pyrophosphatase RdgB [Yersinia pestis biova... gi\|229837638, gi... - gi\|229837638\|ref\|ZP_04457800.1\| dITP/XTP pyrophosphatase [Yersinia pestis Pestoides A], gi\|229704326... gi\|229840864, gi... - gi\|229840864\|ref\|ZP_04461023.1\| dITP/XTP pyrophosphatase [Yersinia pestis biovar Orientalis str. PEX... gi\|229690885, gi... - gi\|229842575\|ref\|ZP_04462730.1\| dITP/XTP pyrophosphatase [Yersinia pestis biovar Orientalis str. Ind... gi\|77633107 - gi\|77633107\|ref\|ZP_00795258.1\| COG0127: Xanthosine triphosphate pyrophosphatase [Yersinia pestis Ang... gi\|89104348 - gi\|89104348\|ref\|ZP_01176894.1\| COG0127: Xanthosine triphosphate pyrophosphatase [Yersinia pestis bio... gi\|149367046, gi... - gi\|149367046\|ref\|ZP_01889079.1\| hypothetical protein YPE_2324 [Yersinia pestis CA88-4125], gi\|149290... gi\|145597877, gi... - gi\|145597877\|ref\|YP_001161953.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Yersinia... gi\|161484757 - gi\|161484757\|ref\|NP_670630.2\| putative deoxyribonucleotide triphosphate pyrophosphatase [Yersinia pe... gi\|165925126, gi... - gi\|165925126\|ref\|ZP_02220958.1\| non-canonical purine NTP pyrophosphatase RdgB [Yersinia pestis biova... gi\|161511311 - gi\|161511311\|ref\|NP_994774.2\| putative deoxyribonucleotide triphosphate pyrophosphatase [Yersinia pe... NTPA_YERPE - Non-canonical purine NTP pyrophosphatase OS=Yersinia pestis GN=YPO0945 PE=3 SV=1 gi\|108778230, gi... - gi\|108806317\|ref\|YP_650233.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Yersinia pe... gi\|229679535, gi... - gi\|229903765\|ref\|ZP_04518878.1\| dITP/XTP pyrophosphatase [Yersinia pestis Nepal516], gi\|229679535\|gb... gi\|15979015, gi\|... - gi\|218928117\|ref\|YP_002345992.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Yersinia...	2.0E-60	[4..192]	[2..194]
gi\|168797529, gi... - gi\|189379716\|gb\|EDU98132.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Escherichia ... gi\|15833084, gi\|... - gi\|15833084\|ref\|NP_311857.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Escherichia ... gi\|189373992, gi... - gi\|189373992\|gb\|EDU92408.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Escherichia ... gi\|189369422, gi... - gi\|189369422\|gb\|EDU87838.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Escherichia ... gi\|12517500, gi\|... - gi\|15803493\|ref\|NP_289526.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Escherichia ... gi\|25323127, gi\|... - pir\|\|A85953 probable ribosomal protein yggV [imported] - Escherichia coli (strain O157:H7, substrain... gi\|217326851, gi... - gi\|217326851\|ref\|ZP_03442934.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Escheric... RDGB_ECO57 - dITP/XTP pyrophosphatase OS=Escherichia coli O157:H7 GN=rdgB PE=3 SV=1	2.0E-60	[4..194]	[2..196]
RDGB_SALTI - dITP/XTP pyrophosphatase OS=Salmonella typhi GN=rdgB PE=3 SV=1 gi\|29138999, gi\|... - gi\|29143365\|ref\|NP_806707.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonella e... HAM1_SALTI, RDGB... - Nucleoside-triphosphatase rdgB OS=Salmonella typhi GN=rdgB PE=3 SV=1, HAM1 protein homolog - Salmone... gi\|213850157 - gi\|213850157\|ref\|ZP_03381055.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213981325 - gi\|213981325\|ref\|ZP_03408584.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|16761878 - gi\|16761878\|ref\|NP_457495.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonella e... gi\|214001052 - gi\|214001052\|ref\|ZP_03411787.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213422842 - gi\|213422842\|ref\|ZP_03355880.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213580618 - gi\|213580618\|ref\|ZP_03362444.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213609098 - gi\|213609098\|ref\|ZP_03368924.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213648209 - gi\|213648209\|ref\|ZP_03378262.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|213051777 - gi\|213051777\|ref\|ZP_03344655.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell...	3.0E-60	[4..194]	[2..196]
gi\|205343452, gi... - gi\|205343452\|gb\|EDZ30216.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonella e... HAM1_SALTY, RDGB... - Nucleoside-triphosphatase rdgB OS=Salmonella typhimurium GN=rdgB PE=3 SV=1, HAM1 protein homolog - S... gi\|194400883, gi... - gi\|194442220\|ref\|YP_002042362.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmone... RDGB_SALTY - dITP/XTP pyrophosphatase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=rdgB PE=... gi\|194406651, gi... - gi\|194448347\|ref\|YP_002047091.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonel... gi\|194472795, gi... - gi\|194472795\|ref\|ZP_03078779.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonel... gi\|167990370, gi... - gi\|205331210\|gb\|EDZ17974.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonella e... gi\|168234346, gi... - gi\|205331687\|gb\|EDZ18451.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonella e... gi\|238909901 - gi\|238909901\|ref\|ZP_04653738.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonell... gi\|168236171, gi... - gi\|197290664\|gb\|EDY30018.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein [Salm... gi\|205338196, gi... - gi\|205338196\|gb\|EDZ24960.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonella e... RDGB_SALPA, HAM1... - dITP/XTP pyrophosphatase OS=Salmonella paratyphi A GN=rdgB PE=3 SV=1, HAM1 protein homolog - Salmone... gi\|160867692, gi... - gi\|161506345\|ref\|YP_001573457.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonel... gi\|161616067, gi... - gi\|161616067\|ref\|YP_001590032.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonel... lcl\|NC_016856.1_... - [gene=yggV] [protein=putative deoxyribonucleotide triphosphate pyrophosphatase] [protein_id=YP_00523... RDGB_SALPA - dITP/XTP pyrophosphatase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=rdgB PE=3 SV=1 RDGB_SALTY - dITP/XTP pyrophosphatase OS=Salmonella typhimurium GN=rdgB PE=3 SV=1 gi\|198243603, gi... - gi\|198243603\|ref\|YP_002217078.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmone... gi\|206710167, gi... - gi\|207858364\|ref\|YP_002245015.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonel... gi\|194736901, gi... - gi\|194736901\|ref\|YP_002116051.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmone... gi\|197250440, gi... - gi\|197250440\|ref\|YP_002148017.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmone... gi\|197240590, gi... - gi\|197262335\|ref\|ZP_03162409.1\| non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family [Salmonel... gi\|197095447, gi... - gi\|197363970\|ref\|YP_002143607.1\| putative deoxyribonucleotide triphosphate pyrophosphatase [Salmonel...	4.0E-60	[4..194]	[2..196]
gi\|170082506, gi... - gi\|170082506\|ref\|YP_001731826.1\| dITP/XTP pyrophosphatase [Escherichia coli str. K-12 substr. DH10B]... gi\|85675764, gi\|... - gi\|89109731\|ref\|AP_003511.1\| dITP/XTP pyrophosphatase [Escherichia coli str. K-12 substr. W3110], gi... gi\|75515266, gi\|... - gi\|75515266\|ref\|ZP_00737450.1\| COG0127: Xanthosine triphosphate pyrophosphatase [Escherichia coli 53... gi\|238902076, gi... - gi\|238902076\|ref\|YP_002927872.1\| dITP/XTP pyrophosphatase [Escherichia coli BW2952], gi\|238860781\|gb... gi\|253772208, gi... - gi\|253772208\|ref\|YP_003035039.1\| non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family [Escheri... HAM1_ECOLI - HAM1 protein homolog - Escherichia coli EG12982 - dITP /XTP pyrophosphatase / dITP /XTP pyrophosphatase, synthetic lethal with recA; mutant is hyper-rec... EG12982 - dITP /XTP pyrophosphatase / dITP /XTP pyrophosphatase, synthetic lethal with recA; mutant is hyper-rec...	8.0E-60	[4..194]	[2..196]

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Predicted Domain #1

Region A:
Residues: [1-77]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNNEIVFVT GNANKLKEVQ SILTQEVDNN NKTIHLINEA LDLEELQDTD LNAIALAKGK  60
   61 QAVAALGKGK PVFVEDT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [120-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTICFADSRG EYHFFQG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [182-197]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKAFAQFKEY LYQNDF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	262.39794
Match:	1b78A_
Description:	XTP pyrophosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleoside-triphosphate diphosphatase activity	2.4486133651528	bayes_pls_golite062009
binding	1.2828743465361	bayes_pls_golite062009
protein binding	0.121994365068808	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [78-119]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALRFDEFNGL PGAYIKWFLK SMGLEKIVKM LEPFENKNAE AV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [137-181]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITRGKIVPSR GPTTFGWDSI FEPFDSHGLT YAEMSKDAKN AISHR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	262.39794
Match:	1b78A_
Description:	XTP pyrophosphatase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: