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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARP4
  • nucleus
  • nuclear chromatin
  • NuA4 histone acetyltransferase complex
  • Swr1 complex
  • Ino80 complex
  • DNA repair
  • chromatin remodeling
  • regulation of transcription, DNA-dependent
  • histone acetylation
  • chromatin organization
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • chromatin binding
  • EAF1
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • chromatin modification
  • DNA repair
  • molecular_function
  • EAF3
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • histone deacetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • histone deacetylase activity
  • EAF5
  • nucleus
  • NuA4 histone acetyltransferase complex
  • DNA repair
  • molecular_function
  • EAF6
  • nucleus
  • NuA4 histone acetyltransferase complex
  • DNA repair
  • molecular_function
  • EAF7
  • nucleus
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • EPL1
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • ESA1
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • RNA elongation
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • SWC4
  • nucleus
  • NuA4 histone acetyltransferase complex
  • Swr1 complex
  • histone acetyltransferase complex
  • chromatin modification
  • DNA repair
  • chromatin remodeling
  • histone exchange
  • histone acetylation
  • DNA binding
  • YAF9
  • nucleus
  • NuA4 histone acetyltransferase complex
  • cytoplasm
  • Swr1 complex
  • DNA repair
  • chromatin remodeling
  • histone exchange
  • chromatin silencing at telomere
  • molecular_function
  • YNG2
  • nucleus
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • chromatin modification
  • DNA repair
  • histone acetylation
  • enzyme activator activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    NuA4 histone acetyltransferase complex 2.3954E-32 11 14 11 6292
    H4/H2A histone acetyltransferase complex 2.3954E-32 11 14 11 6292
    histone acetyltransferase complex 5.047E-25 11 44 11 6292
    nucleoplasm part 2.5063E-16 11 245 11 6292
    nucleoplasm 5.7951E-16 11 264 11 6292
    nuclear lumen 2.4047E-13 11 453 11 6292
    organelle lumen 1.5694E-11 11 660 11 6292
    intracellular organelle lumen 1.5694E-11 11 660 11 6292
    membrane-enclosed lumen 3.0124E-11 11 700 11 6292
    Piccolo NuA4 histone acetyltransferase complex 3.9763E-9 11 3 3 6292
    nuclear part 4.6103E-9 11 1103 11 6292
    protein complex 6.4478E-9 11 1137 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    Swr1 complex 1.7886E-6 11 15 3 6292
    nucleus 4.1084E-6 11 2041 11 6292
    organelle part 1.4064E-5 11 2282 11 6292
    intracellular organelle part 1.4064E-5 11 2282 11 6292
    nuclear chromatin 2.3129E-4 11 73 3 6292
    chromatin 2.7098E-4 11 77 3 6292
    chromatin remodeling complex 5.6891E-4 11 99 3 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    nuclear chromosome part 3.7388E-3 11 190 3 6292
    nuclear chromosome 6.2442E-3 11 228 3 6292
    chromosomal part 6.9559E-3 11 237 3 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA repair 1.6095E-17 11 192 11 6292
    response to DNA damage stimulus 1.6459E-16 11 236 11 6292
    cellular response to stress 1.6601E-15 11 290 11 6292
    cellular response to stimulus 3.3002E-14 11 379 11 6292
    histone acetylation 3.5108E-14 11 36 7 6292
    protein amino acid acetylation 2.2386E-13 11 46 7 6292
    chromatin modification 2.9299E-13 11 168 9 6292
    response to stress 6.7397E-13 11 497 11 6292
    protein amino acid acylation 1.4164E-12 11 59 7 6292
    chromatin organization 1.6543E-12 11 203 9 6292
    DNA metabolic process 4.1187E-12 11 585 11 6292
    covalent chromatin modification 2.5932E-11 11 88 7 6292
    histone modification 2.5932E-11 11 88 7 6292
    response to stimulus 8.1717E-11 11 766 11 6292
    chromosome organization 1.4235E-8 11 555 9 6292
    nucleic acid metabolic process 7.2197E-8 11 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2108E-7 11 1566 11 6292
    post-translational protein modification 4.8387E-7 11 357 7 6292
    cellular nitrogen compound metabolic process 8.537E-7 11 1770 11 6292
    nitrogen compound metabolic process 9.7232E-7 11 1791 11 6292
    protein modification process 4.7177E-6 11 499 7 6292
    organelle organization 7.1732E-6 11 1127 9 6292
    macromolecule modification 1.1399E-5 11 569 7 6292
    regulation of transcription, DNA-dependent 1.1785E-5 11 358 6 6292
    regulation of RNA metabolic process 1.277E-5 11 363 6 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    regulation of transcription 1.7669E-5 11 384 6 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    regulation of transcription from RNA polymerase II promoter 2.3113E-5 11 228 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.7615E-5 11 415 6 6292
    regulation of nitrogen compound metabolic process 2.7999E-5 11 416 6 6292
    regulation of gene expression 4.1181E-5 11 445 6 6292
    regulation of macromolecule biosynthetic process 4.7341E-5 11 456 6 6292
    regulation of cellular biosynthetic process 5.7619E-5 11 472 6 6292
    regulation of biosynthetic process 5.8317E-5 11 473 6 6292
    regulation of macromolecule metabolic process 6.9639E-5 11 488 6 6292
    transcription, DNA-dependent 8.2682E-5 11 503 6 6292
    RNA biosynthetic process 8.7445E-5 11 508 6 6292
    regulation of primary metabolic process 9.3452E-5 11 514 6 6292
    regulation of cellular metabolic process 1.184E-4 11 536 6 6292
    histone exchange 1.241E-4 11 10 2 6292
    cellular component organization 1.3041E-4 11 1582 9 6292
    regulation of metabolic process 1.3275E-4 11 547 6 6292
    transcription 1.3973E-4 11 552 6 6292
    transcription from RNA polymerase II promoter 1.4703E-4 11 335 5 6292
    chromatin remodeling 1.8726E-4 11 68 3 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    metabolic process 5.03E-4 11 3157 11 6292
    cellular protein metabolic process 7.2248E-4 11 1074 7 6292
    ATP-dependent chromatin remodeling 8.8271E-4 11 26 2 6292
    protein metabolic process 1.0289E-3 11 1136 7 6292
    regulation of cellular process 1.0568E-3 11 796 6 6292
    nucleosome organization 1.0996E-3 11 29 2 6292
    regulation of biological process 1.274E-3 11 824 6 6292
    RNA metabolic process 2.7847E-3 11 954 6 6292
    cellular macromolecule biosynthetic process 8.6337E-3 11 1187 6 6292
    macromolecule biosynthetic process 8.7077E-3 11 1189 6 6292
    biological regulation 9.6331E-3 11 1213 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone acetyltransferase activity 1.1899E-8 11 17 4 6292
    lysine N-acetyltransferase activity 1.1899E-8 11 17 4 6292
    N-acetyltransferase activity 2.0169E-7 11 33 4 6292
    N-acyltransferase activity 3.622E-7 11 38 4 6292
    acetyltransferase activity 1.118E-6 11 50 4 6292
    transferase activity, transferring acyl groups other than amino-acyl groups 1.3063E-5 11 92 4 6292
    acyltransferase activity 1.3063E-5 11 92 4 6292
    transferase activity, transferring acyl groups 2.3803E-5 11 107 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle