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Protein Overview: MRM1

General Information:
Name(s) found: MRM1 / YOR201C [SGD]
Description(s) found:
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  • gi|6324775|ref|NP_014844.1| Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Mrm1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S48881 rRNA (guanosine-2'-O-)-methyltransferase (EC 2.1.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|431760|gb|AAA74564.1| ribosomal RNA methylase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1420475|emb|CAA99414.1| PET56 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1346886|sp|P25270.2|MRM1_YEAST RecName: Full=rRNA methyltransferase, mitochondrial; AltName: Full=Mitochondrial large ribosomal RNA ribose methylase; AltName: Full=21S rRNA [GM2251] 2'O-methyltransferase; Flags: Precursor [NCBI NR]
  • (P25270) Ribose methyltransferase PET56 (EC 2.1.1.-) (Mitochondrial large ribosomal RNA ribose methylase) (21S rRNA [GM2251] 2'O-methyltransferase) [Swiss-Prot]
  • rRNA methyltransferase, mitochondrial OS=Saccharomyces cerevisiae GN=MRM1 PE=1 SV=2 [Swiss-Prot]
  • MRM1 rRNA (guanosine-2`-O-)-methyltransferase for mitochondrial 21S rRNA [mips]
  • Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA [SGD]
  • Chr XV from 721708-720470, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 720469-721707, reverse complement [yeastorf3.fasta]
  • Chr XV from 720470-721708, reverse complement [yeastorf4.fasta]
  • PET56, Chr XV from 720469-721707, reverse complement [yeast_orfs2]
  • PET56 SGDID:S0005727, Chr XV from 721708-720470, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Pet56p [Saccharomyces cerevisiae]gi|1420475|emb|CAA99414.1| PET56 [Saccharomyces cerevisiae]gi|630329|pir||S48881 rRNA (guanosine-2'-O-)-methyltransferase (EC 2.1.1.-) - yeast (Saccharomyces cerevisiae)gi|431760|gb|AAA74564.1| ribosomal RNA methylaseg [nrdb_11152004_Chlamydomonas]
  • YOR201C SGDID:S000005727, Chr XV from 721708-720470, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • YOR201C SGDID:S000005727, Chr XV from 721709-720471, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [yeast-contam.fasta]
  • MRM1 SGDID:S000005727, Chr XV from 721709-720471, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • PET56 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Mrm1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ribose methyltransferase PET56 (Mitochondrial large ribosomal RNA ribose methylase) (21S rRNA [GM2251] 2'O-methyltransferase) [nr-271106-contam.fasta]
  • ribosomal RNA methylase [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • rRNA methyltransferase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRM1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MRM1 SGDID:S000005727, Chr XV from 721708-720470, Genome Release 64-1-1, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [yeast-030211-contam.fasta]
  • MRM1 SGDID:S000005727, Chr XV from 721708-720470, Genome Release 64-2-1, reverse complement, Verified ORF, "Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [20141208_orf_trans.fasta]
  • YOR201C SGDID:S000005727, Chr XV from 721708-720470, Genome Release 64-1-1, reverse complement, Verified ORF, "Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • rRNA methyltransferase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRM1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 412 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    Biological Process: rRNA modification [IDALink to PubMed article]
    Molecular Function: rRNA (guanine-N1-)-methyltransferase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSLTNAVFK RYLAVTPSAH QALKTRIKKK SSSFDKFFPQ QSNSRKKQWE TLNEDKASWF  60
   61 KRKYAHVHAR EQDRAADPYG KKKAHVEKLK EIKNQAKLNQ KSHKSKFQNK DIALKLMNDN 120
  121 PIFEYVYGTN SVYAALLNPS RNCHSRLLYH GTIPSKFLQI VDELKVTTEL VDKHRLNLLT 180
  181 NYGVHNNIAL ETKPLQPVEI AYLGDMDTSS AALSIHELGF NNENIPHELP YGTKTDAKKF 240
  241 PLGLYLDEIT DPHNIGAIIR SAYFLGVDFI VMSRRNCSPL TPVVSKTSSG ALELLPIFYV 300
  301 DKPLEFFTKS QEMGGWTFIT SHLANATSEK YTVGKTISMH DLNGLCNELP VVLVVGNESQ 360
  361 GVRTNLKMRS DFFVEIPFGG IEKGNRAPEP IVDSLNVSVA TALLIDNILT CK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
    View Details Gavin AC, et al. (2006) MRM1 MRPL36
    View Details Gavin AC, et al. (2002) ATG26 BEM2 BUD3 COP1 CYR1 HRR25 IMG1 IMG2 IML1 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 NUG1 PRP43 RET2 ROM2 RTC6 SEC1 SEC26 SEC27 SIN4 SNF2 SWI3 SYP1 TAF5 UTP20 YDR115W YML6
    View Details Ho Y, et al. (2002) CBF5 DBP7 EST1 HSH49 KRE33 MRM1 MSS116 PDI1 PUF6 PWP1 RPF2 RRP1 RRP12 URB1 UTP10 YER077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] MSA 1.058969 View MSA. No confident structure predictions are available.
    2 View Details [86..230] PSI-BLAST 36.39794 RrmH, C-terminal domain; RrmH, N-terminal domain
    3 View Details [231..412] PSI-BLAST 36.39794 RrmH, C-terminal domain; RrmH, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • RNA methyltransferase activity
    		•  4.23455016472464 bayes_pls_golite062009
  • methyltransferase activity
    		•  3.59960278169345 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  3.51722801996622 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  3.14976989427746 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.33123191403389 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.23755555119187 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  2.14623472760939 bayes_pls_golite062009
  • transferase activity
    		•  1.63934797352054 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.0137045454994 bayes_pls_golite062009
  • catalytic activity
    		•  0.797300463760338 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  0.736216022000293 bayes_pls_golite062009
  • structural molecule activity
    		•  0.694233763389628 bayes_pls_golite062009
  • binding
    		•  0.650146274744039 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.404179021204849 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  0.319046095835882 bayes_pls_golite062009
    		• 0.16936231012632 bayes_pls_golite062009
  • snoRNA binding
    		•  0.155192244522672 bayes_pls_golite062009
  • protein binding
    		•  0.031057919963412 bayes_pls_golite062009
  • rRNA (guanine-N1-)-methyltransferase activity
    		•  6.26422903788337E-4 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle