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Protein Overview: DIA2

General Information:
Name(s) found: DIA2 / YOR080W [SGD]
Description(s) found:
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  • gi|74583720|sp|Q08496.1|DIA2_YEAST RecName: Full=Protein DIA2; AltName: Full=Digs into agar protein 2 [NCBI NR]
  • gi|6324654|ref|NP_014723.1| Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth; Dia2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S66963 hypothetical protein YOR080w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|2104892|emb|CAA94565.1| YOR29-31 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1420241|emb|CAA99273.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Protein DIA2 OS=Saccharomyces cerevisiae GN=DIA2 PE=1 SV=1 [Swiss-Prot]
  • DIA2 Protein involved in invasive and pseudohyphal growth [mips]
  • Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth [SGD]
  • >Q08496 (Q08496) Chromosome XV reading frame ORF YOR080W [4932.FASTACCERV.txt]
  • Chr XV from 474553-476793 [hmr_yeast5_DM3-1_pombe.fasta]
  • DIA2, Chr XV from 474553-476793 [yeast_orfs2]
  • DIA2 SGDID:S0005606, Chr XV from 474553-476793, Verified ORF [yeastflysequest.fasta]
  • Dia2p [Saccharomyces cerevisiae]gi|2104892|emb|CAA94565.1| YOR29-31 [Saccharomyces cerevisiae]gi|1420241|emb|CAA99273.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132050|pir||S66963 hypothetical protein YOR080w - yeast (Saccharomyces cerevi [nrdb_11152004_Chlamydomonas]
  • (Q08496) S.cerevisiae chromosome XV reading frame ORF YOR080w (YOR29-31 protein) [cerv4932.FASTAC]
  • DIA2 SGDID:S000005606, Chr XV from 474553-476793, Verified ORF, "Protein of unknown function, involved in invasive and pseudohyphal growth" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • DIA2 SGDID:S000005606, Chr XV from 474554-476794, Verified ORF, "Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth" [yeast-contam.fasta]
  • Protein DIA2 (Digs into agar protein 2) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YOR29-31 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth; Dia2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 746 amino acids

    Gene Ontology:
    Cellular Component: SCF ubiquitin ligase complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: DNA replication [IMPLink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    protein ubiquitination [IMPLink to PubMed article]
    Molecular Function: DNA replication origin binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFITKNK KYTPMSSPGN SGVAIDSTVL KAIELGTRLF KSGEYLQAKR IFTNALRVCD  60
   61 SYSQEQIMRI RNAYQLDTAR PDNKRLYHPR YIKILDNICA CYEKLNDLKS CLDVSQRLLK 120
  121 LEPGNIKCYI RCTRTLIKLK DWKRAYKTCS RGLQLCNNDS NHLRQQKQFI KNNMVQKQDG 180
  181 KRSYIDPLEE TKIAKKKKNN NVLESLPKKK IKGSTKKTDL VGNLPIEILP IIFQRFTTKE 240
  241 LVTLSLVCNK WRDKILYHLD CFQEFNLAPI NFKNFVKFMD FLQQNFTRTY RKYILSQVKV 300
  301 SSRITSEELR ITQLLFSKMP KCINIERLIL SMPTLTTTQI FKLMVRGGTD FFTRLLELSL 360
  361 MITYRPDKQH ELEILQTCPL LKKIELIFVN SLVPIFDGNN SVGRDGSFNV MARHTNMQIS 420
  421 TADNDEQGIV EEKVIYSELE KITLICDKKK IKNFPLCRAL LRGQFPLLQK LTITGVTFPM 480
  481 NNQDIMNFQW LLNFPDLKEL WIEDNDNCEL SKFLQLLKFS NVWKNLEKLT FRENKLYPIV 540
  541 NLDEDQPVTN DDEVPSMLFY KENLQNLEKL DLMGTSISGS ALTRLCEQEY LDGRKLRSLN 600
  601 IGNCPNIQFP NNHAHTARMI LDVNAVLKRL SKLEEINLSH LSSLNDSTMK SFIINVPFLE 660
  661 NLKRLDISHN FEITGISIYE FLKKFQMDHD NEAGGQPLAY LNIDGCSQVS HITVNMIRAQ 720
  721 NLVTQVDCVY ERDVWRKFGI NSYSYS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) BMS1 CDC53 CIC1 CKS1 COF1 CTF4 DBP10 DED81 DIA2 ENP1 FPR3 ILS1 KRE33 KRI1 LST4 MCM2 MCM3 MCM5 NIP7 NMD3 NOP12 RRP12 SEH1 SKP1 SLT2 SPB1 SSF1 SSF2 SSZ1 TIF6 URB1 UTP10 YAK1 YBL104C
    View Details Qiu et al. (2008) CDC53 DIA2 SKP1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SXM1 DIA2 1 Unpublished Fields Lab Data
    View Screen DMC1 DIA2 1 Unpublished Fields Lab Data
    View Screen DIA2 RPA14 1 Unpublished Fields Lab Data
    View Screen DIA2 YER184C 1 Unpublished Fields Lab Data
    View Screen DIA2 CDC12 1 Unpublished Fields Lab Data
    View Screen DIA2 YIR014W 1 Unpublished Fields Lab Data
    View Screen DIA2 RPA12 1 Unpublished Fields Lab Data
    View Screen DIA2 TVP38 1 Unpublished Fields Lab Data
    View Screen DIA2 WHI5 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] ORFEUS 14.61 Vesicular transport protein sec17
    2 View Details [216..266] Pfam 3.05061 F-box domain No confident structure predictions are available.
    3 View Details [267..610] deduced N/A No confident structure predictions are available.
    4 View Details [611..746] MSA 1.002943 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.838457647933563 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  0.788209490718562 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  0.728844238348547 bayes_pls_golite062009
  • binding
    		•  0.436537606536136 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.238548113422564 bayes_pls_golite062009
  • protein binding
    		•  0.218634943775696 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0817192853858701 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0284131677759829 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle