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Protein Overview: INP52

General Information:
Name(s) found: INP52 / YNL106C [SGD]
Description(s) found:
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  • gi|6324224|ref|NP_014293.1| Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 dom [NCBI NR]
  • pir||S63046 probable membrane protein YNL106c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730760|sp|P50942.1|INP52_YEAST RecName: Full=Inositol-1,4,5-trisphosphate 5-phosphatase 2; AltName: Full=Synaptojanin-like protein 2 [NCBI NR]
  • gi|1302022|emb|CAA95982.1| PIE3 [Saccharomyces cerevisiae] [NCBI NR]
  • Uncharacterized protein YNL106C OS=Saccharomyces cerevisiae GN=YNL106C PE=1 SV=1 [Swiss-Prot]
  • Inositol-1,4,5-trisphosphate 5-phosphatase 2 OS=Saccharomyces cerevisiae GN=INP52 PE=1 SV=1 [Swiss-Prot]
  • INP52 Phosphatidylinositol phosphate phosphatase [mips]
  • Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain [SGD]
  • INP52, Chr XIV from 420941-424492, reverse complement [yeast_orfs2]
  • Chr XIV from 420941-424492, reverse complement [yeastorf3.fasta]
  • Chr XIV from 424492-420941, reverse complement [yeastorf5.fasta]
  • (P50942) Hypothetical 133.3 kDa protein in CYB5-LEU4 intergenic region [4932.FASTACCERV.txt]
  • INP52 SGDID:S0005050, Chr XIV from 424495-420944, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Inp52p [Saccharomyces cerevisiae]gi|1302022|emb|CAA95982.1| PIE3 [Saccharomyces cerevisiae]gi|2132747|pir||S63046 probable membrane protein YNL106c - yeast (Saccharomyces cerevisiae)gi|1730760|sp|P50942|YNK6_YEAST Hypothetical 133.3 kDa protein in CYB5 [nrdb_11152004_Chlamydomonas]
  • INP52 SGDID:S000005050, Chr XIV from 424497-420946, reverse complement, Verified ORF, "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes t [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • INP52 SGDID:S000005050, Chr XIV from 424497-420946, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Uncharacterized protein YNL106C [nr-271106-contam.fasta]
  • Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches; Inp52p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PIE3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • INP52 SGDID:S000005050, Chr XIV from 424497-420946, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain" [yeast-bovrabprots.fasta]
  • INP52 SGDID:S000005050, Chr XIV from 424497-420946, reverse complement, Verified ORF, "Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in endocytosis; hyperosmotic stress causes translocation to actin patches" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Polyphosphatidylinositol phosphatase INP52 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=INP52 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • INP52 SGDID:S000005050, Chr XIV from 424495-420944, Genome Release 64-1-1, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain" [yeast-030211-contam.fasta]
  • INP52 SGDID:S000005050, Chr XIV from 424495-420944, Genome Release 64-2-1, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL106C SGDID:S000005050, Chr XIV from 424495-420944, Genome Release 64-1-1, reverse complement, Verified ORF, "Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1183 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    actin cortical patch [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cellular cell wall organization [IGILink to PubMed article]
    inositol lipid-mediated signaling [TASLink to PubMed article]
    endocytosis [IGILink to PubMed article]
    phosphoinositide dephosphorylation [ISSLink to PubMed article]
    Molecular Function: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [IDALink to PubMed article]
    [NOT]inositol-polyphosphate 5-phosphatase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKILLSKQQT RKIAIVSETH GLVFRPINSK NSRRSTCAVE LVPKAELNGN GFRRLSNHEI  60
   61 YGFIGLIEIE GLMFIATITG KSKVAQPIPN KTVNKIYAVD FFCLNNSKWD FMDIDSSGYP 120
  121 IVTNDGDFAI SSPPSISTHS SRSSLRSSSS RSLNAQEQAP KHPCHELRKL LSNGSFYYST 180
  181 DFDLTCTLQK RGFTEHSLSF DDFDREFMWN SFLMDEIITY RDRLDVTAKE LLDQRGFLTT 240
  241 VIRGFAETIF SYINRLKVGL TIISRQSWKR AGTRFNARGI DDDGHVANFV ETEMIMYSSQ 300
  301 YCYAFTQIRG SLPIFWEQDT SLISPKIQIT RSVEATQPTF DEHFIRLFKK YGPVHIINLL 360
  361 STKSSEIQLS RRYKEQLKNS EKMKIGRDVF LTSFDFHRET SQDGFAAASR IIPKIRNTIL 420
  421 DAGYFSYDVK EGRLISEQDG VFRTNCLDCL DRTNLIQQTI SLAVFKLFLE DFRLVKPSSF 480
  481 IDDNEFVQKV NALWADNGDQ ISQIYTGTNA LKSSYSRKGK MSFSGALSDA TKSVSRMYIN 540
  541 NFVDKGKQQN IDTLLGKLPH QQVVELYDPI CEYVNERLLE SEEKFTTHSN INLFVGTFNV 600
  601 NGNSRRADLS KWLFPIGDKF KPDVVVLGLQ EVIELTAGSI LNADYTKSSF WETMVTDCLN 660
  661 QYEEKYLLLR VEQMSSLLIL FFARSDRAYN IKEVGGSTKK TGFGGITGNK GAVAIRFDYG 720
  721 ATSFCFVNTH LSAGASNIDE RRNDYNNIYR NITFPRSKTI PHHDSLFWLG DLNYRITLTN 780
  781 DEVRRELRAQ KDGYIDRLLQ YDQLTQEINE GVVFQGFKEP TLQFRPTYKY DYGTDNYDTS 840
  841 EKARTPSWTD RIIYKGENLH PLAYSDAPLK ISDHKPVYAA YRANVKFVDE KEKLNLVEKL 900
  901 YAEYKNTHPE ALTTGPDELS HARMEKQKES IPLDATVQSA GIKLIDLDDT SSCVSPLLSG 960
  961 PSPQPSVVGP GGLSNVSPDK SKLNVLPPPP PTSRHNKEPS SKLLSPTKEI SIVSVSPRKG1020
 1021 ESNLPALERH STPKPLPPVP ALSLSKPVSL QKSSSELQHA KETIDNGKIV PRPCPPIRRK1080
 1081 SSTAPDEIST STKNSGVSTT EDPEPAKAST KPEKPPVVKK PHYLSVAANK LNTSQEHSIK1140
 1141 VSPSNSKSEE ELPCKKKSKP KVPAKNPELE KLSVHPLKPC DPN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ABP1 BSP1 CAP1 CMD1 CRN1 INP52 LSP1 MLC1 NOP53 PIL1 RVS161 SLM1
    View Details Krogan NJ, et al. (2006) ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
    View Details Gavin AC, et al. (2002) BSP1 BZZ1 CHC1 ECM25 END3 INP52 LAS17 LSB3 RAD51 SLA1 SLA2 STM1 SYP1 TFP1 VRP1 YPT7 YSC84
    View Details Ho Y, et al. (2002) ADO1 INP52 POR1 RNH202 RNQ1 SAP190 TIF1, TIF2 YHB1
    View Details Qiu et al. (2008) INP51 INP52 INP53

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run BOI1 Sample boi1 with gst from october 2005 McCusker D, et al (2007)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen INP52 PTP1 2 Unpublished Fields Lab Data
    View Screen INP52 SVL3 2 Unpublished Fields Lab Data
    View Screen INP52 VPS4 2 Unpublished Fields Lab Data
    View Screen INP52 YDR026C 2 Unpublished Fields Lab Data
    View Screen INP52 MLC2 2 Unpublished Fields Lab Data
    View Screen INP52 RTT105 2 Unpublished Fields Lab Data
    View Screen INP52 SHG1 1 Unpublished Fields Lab Data
    View Screen INP52 YNR062C 1 Unpublished Fields Lab Data
    View Screen INP52 RVS161 1 Unpublished Fields Lab Data
    View Screen INP52 RGA1 1 Unpublished Fields Lab Data
    View Screen INP52 YDL144C 1 Unpublished Fields Lab Data
    View Screen INP52 TAF3 1 Unpublished Fields Lab Data
    View Screen INP52 SNQ2 1 Unpublished Fields Lab Data
    View Screen INP52 IVY1 1 Unpublished Fields Lab Data
    View Screen INP52 ARR2 1 Unpublished Fields Lab Data
    View Screen INP52 ARC1 1 Unpublished Fields Lab Data
    View Screen INP52 BUD9 1 Unpublished Fields Lab Data
    View Screen INP52 VPS62 1 Unpublished Fields Lab Data
    View Screen YDR131C INP52 1 Unpublished Fields Lab Data
    View Screen INP52 MRPS35 1 Unpublished Fields Lab Data
    View Screen IST3 INP52 1 Unpublished Fields Lab Data
    View Screen INP52 SUL2 1 Unpublished Fields Lab Data
    View Screen UBC7 INP52 1 Unpublished Fields Lab Data
    View Screen INP52 ASP3-4, ASP3-1, ... 1 Unpublished Fields Lab Data
    View Screen INP52 SAW1 1 Unpublished Fields Lab Data
    View Screen INP52 TMA23 1 Unpublished Fields Lab Data
    View Screen INP52 YBL059W 1 Unpublished Fields Lab Data
    View Screen INP52 DMA2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data INP52 Huh WK, et al. (2003)
    View Data INP52 and SAC6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..475] Pfam 183.337242 SacI homology domain No confident structure predictions are available.
    2 View Details [476..559] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [560..938] PSI-BLAST 904.9897 Synaptojanin, IPP5C domain
    4 View Details [939..1183] ab initio 11.26 No description for 1deqA was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle