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Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. Catalysis of the removal the of the 5-phosphate group of a phosphatidylinositol phosphate. Catalysis of the removal of one of the two phosphate groups of a phosphatidylinositol bisphosphate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Acc: GO:0004439
Aspect: Molecular Function
Desc: Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Synonyms:
  • phosphatidylinositol-bisphosphatase activity
  • PtdIns(4,5)P(2) phosphatase activity
  • GO:0001668
  • phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity
  • inositol 1,4,5-triphosphate 5-phosphomonoesterase activity
  • phosphatidylinositol 4,5-bisphosphate phosphatase activity
  • triphosphoinositide phosphatase activity
  • PtdIns(4,5)P2 phosphatase activity
  • triphosphoinositide phosphomonoesterase activity
Proteins in PDR annotated with:
   This term: 32 [Search]
   Term or descendants: 32 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle